Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1

ChemMedChem ◽  
2016 ◽  
Vol 11 (20) ◽  
pp. 2327-2338 ◽  
Author(s):  
Dina Robaa ◽  
Tobias Wagner ◽  
Chiara Luise ◽  
Luca Carlino ◽  
Joel McMillan ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

scholarly journals Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation

2012 ◽  
Vol 287 (41) ◽  
pp. 34786-34800 ◽  
Author(s):  
Heiko Kroth ◽  
Annalisa Ansaloni ◽  
Yvan Varisco ◽  
Asad Jan ◽  
Nampally Sreenivasachary ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Fibril Formation ◽  
Activity Relationship ◽  
Structure Activity ◽  
Β Amyloid ◽  
Relationship Of

scholarly journals Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1)

MedChemComm ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 1793-1796 ◽  
Author(s):  
H. Ü. Kaniskan ◽  
M. S. Eram ◽  
J. Liu ◽  
D. Smil ◽  
M. L. Martini ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
High Potency ◽  
Arginine Methyltransferase ◽  
Design And Synthesis ◽  
Structure Activity ◽  
Methyltransferase 1

Structure–activity relationship studies, starting from a fragment hit, resulted in discovery of the compound 9, an inhibitor of CARM1 with high potency and selectivity.

Structure–Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

2017 ◽  
Vol 60 (12) ◽  
pp. 5015-5028 ◽  
Author(s):  
Harshini Neelakantan ◽  
Hua-Yu Wang ◽  
Virginia Vance ◽  
Jonathan D. Hommel ◽  
Stanton F. McHardy ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D

2021 ◽  
Vol 29 ◽  
pp. 115879
Author(s):  
Sandeep Goyal ◽  
Ketul V. Patel ◽  
Yadav Nagare ◽  
Digambar B. Raykar ◽  
Santosh S. Raikar ◽  
...  
Keyword(s):  
Small Molecule ◽  
Cathepsin D ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Human Cathepsin

scholarly journals Structure–activity relationship studies of small-molecule inhibitors of Wnt response

2009 ◽  
Vol 19 (14) ◽  
pp. 3825-3827 ◽  
Author(s):  
Jianming Lu ◽  
Zhiqiang Ma ◽  
Jen-Chieh Hsieh ◽  
Chih-Wei Fan ◽  
Baozhi Chen ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription

Biopolymers ◽  
2010 ◽  
Vol 95 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Marcelo Actis ◽  
Michele C. Connelly ◽  
Anand Mayasundari ◽  
Chandanamali Punchihewa ◽  
Naoaki Fujii
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study
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