Distinct roles of a tyrosine-associated hydrogen-bond network in fine-tuning the structure and function of heme proteins: two cases designed for myoglobin

2016 ◽  
Vol 12 (10) ◽  
pp. 3139-3145 ◽  
Author(s):  
Fei Liao ◽  
Hong Yuan ◽  
Ke-Jie Du ◽  
Yong You ◽  
Shu-Qin Gao ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Active Site ◽  
Heme Proteins ◽  
Structure And Function ◽  
Fine Tuning ◽  
Hydrogen Bond Network ◽  
Protein Properties ◽  
Bond Network ◽  
And Function

A single Tyr introduced in the secondary sphere of the heme active site in myoglobin at position 107 or 138 forms a distinct Tyr-associated H-bond network, regulating both the protein properties and functions.

scholarly journals Rhomboids make do with a weak hydrogen bond

2019 ◽  
Vol 151 (3) ◽  
pp. 274-274 ◽  
Author(s):  
Caitlin Sedwick
Keyword(s):  
Hydrogen Bond ◽  
Active Site ◽  
Hydrogen Bond Network ◽  
Weak Hydrogen Bond ◽  
Bond Network

JGP paper explores the strength of the hydrogen bond network at the active site of GlpG.

scholarly journals Quantum delocalization of protons in the hydrogen-bond network of an enzyme active site

2014 ◽  
Vol 111 (52) ◽  
pp. 18454-18459 ◽  
Author(s):  
Lu Wang ◽  
Stephen D. Fried ◽  
Steven G. Boxer ◽  
Thomas E. Markland
Keyword(s):  
Hydrogen Bond ◽  
Active Site ◽  
Hydrogen Bond Network ◽  
Enzyme Active Site ◽  
Bond Network ◽  
Quantum Delocalization

scholarly journals Altered Orientation of Active Site Residues in Variants of Human Ferrochelatase. Evidence for a Hydrogen Bond Network Involved in Catalysis†

Biochemistry ◽  
2007 ◽  
Vol 46 (27) ◽  
pp. 7973-7979 ◽  
Author(s):  
Harry A. Dailey ◽  
Chia-Kuei Wu ◽  
Peter Horanyi ◽  
Amy E. Medlock ◽  
Wided Najahi-Missaoui ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Active Site ◽  
Hydrogen Bond Network ◽  
Active Site Residues ◽  
Bond Network

scholarly journals Structure and Function Converge To Identify a Hydrogen Bond in a Group I Ribozyme Active Site

2009 ◽  
Vol 48 (39) ◽  
pp. 7171-7175 ◽  
Author(s):  
Marcello Forconi ◽  
Raghuvir N. Sengupta ◽  
Mao-Chin Liu ◽  
Alan C. Sartorelli ◽  
Joseph A. Piccirilli ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Active Site ◽  
Structure And Function ◽  
Group I ◽  
And Function

scholarly journals Interrupting the Hydrogen Bond Network at the Active Site of Human Manganese Superoxide Dismutase

1999 ◽  
Vol 274 (39) ◽  
pp. 27711-27716 ◽  
Author(s):  
Cecilia A. Ramilo ◽  
Vincent Leveque ◽  
Yue Guan ◽  
James R. Lepock ◽  
John A. Tainer ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Superoxide Dismutase ◽  
Active Site ◽  
Manganese Superoxide Dismutase ◽  
Hydrogen Bond Network ◽  
Manganese Superoxide ◽  
Bond Network

A hydrogen-bond network at the active site of subtilisin BPN'

1970 ◽  
Vol 257 (813) ◽  
pp. 119-124 ◽  
Keyword(s):  
Hydrogen Bond ◽  
Active Site ◽  
Serine Proteases ◽  
Catalytic Mechanism ◽  
Three Dimensional ◽  
Hydrogen Bond Network ◽  
The Common ◽  
Bond Network ◽  
The One ◽  
Active Site Region

Further examination of the active site region in our X-ray crystallographic model of subtilisin BPN' reveals a hydrogen-bond network that bears a remarkable resemblance to the one found in a- chymotrypsin. It involves the side chains of the reactive Ser-221, His-64, Asp-32 and Ser-33. Otherwise the two enzymes have entirely different three-dimensional structures. This observation suggests that the common hydrogen bond network plays some essential role in the catalytic mechanism of serine proteases generally.

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