Developmental exposure to paraquat and maneb can impair cognition, learning and memory in Sprague-Dawley rats

2016 ◽  
Vol 12 (10) ◽  
pp. 3088-3097 ◽  
Author(s):  
Bai Li ◽  
Xi He ◽  
Yan Sun ◽  
Baixiang Li
Keyword(s):  
Cognitive Function ◽  
Signaling Pathway ◽  
Learning And Memory ◽  
Sprague Dawley ◽  
Developmental Exposure ◽  
Rat Offspring ◽  
Sprague Dawley Rats

PQ–MB may affect the behavior and cognitive function of rat offspring through the cAMP–PKA–CREB signaling pathway.

Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus

2021 ◽  
pp. 074823372098462
Author(s):  
Chong Wang ◽  
Yao Shu ◽  
Li Xu ◽  
Qiling Liu ◽  
Bei Zhang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Learning And Memory ◽  
Maternal Exposure ◽  
Male Offspring ◽  
Male Rat ◽  
Control Group ◽  
Sprague Dawley ◽  
Expression Levels ◽  
Rat Offspring ◽  
Sprague Dawley Rats

Bisphenol A (BPA), a component of polycarbonate and epoxy resins, has been reported to induce learning and memory deficits. However, the mechanisms have not been fully elucidated. Growing evidence has suggested that N-methyl-d-aspartate receptors (NMDARs) are involved in cognitive impairments. In this study, BPA was administered to female Sprague–Dawley rats (six per dose group) at concentrations of 0 (control), 4, 40, and 400 μg/kg·body weight/day from gestation day 1 through lactation day 21. Spatial learning was evaluated using the Morris water maze on postnatal day 22. Expression levels of NMDARs were determined using real-time polymerase chain reaction and Western blot. The results showed that male offspring exposed to BPA exhibited increased latency in reaching the platform and reduced time in the target quadrant, and the number of crossing the platform was less, as compared with the control group. The mRNA and protein expression levels of NMDARs in the hippocampus were significantly downregulated when compared with the control group of male offspring. The data showed that maternal exposure to BPA at low dosage can cause cognitive deficits in male rat offspring, probably due to a decrease in NMDARs in the hippocampus.

scholarly journals Prenatal Caffeine Damaged Learning and Memory in Rat Offspring Mediated by ARs/PKA/CREB/BDNF Pathway

2018 ◽  
pp. 975-983 ◽  
Author(s):  
Y. LI ◽  
W. ZHANG ◽  
R. SHI ◽  
M. SUN ◽  
L. ZHANG ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Maze Learning ◽  
Adult Offspring ◽  
Sprague Dawley ◽  
Long Term Effects ◽  
Developmental Problems ◽  
A2a Receptors ◽  
Rat Offspring ◽  
Sprague Dawley Rats

Prenatal exposure to caffeine can cause developmental problems. This study determined chronic influence of prenatal caffeine at relatively higher doses on cognitive functions in the rat offspring. Pregnant Sprague-Dawley rats (4-month-old) were exposed to caffeine (20 mg/kg, twice a day) for whole pregnancy from gestational day 4. Fetal and offspring body and brain weight was measured. Learning and memory were tested in adult offspring with Morris water maze. Learning and memory-related receptors were measured. The exposure to prenatal caffeine not only caused fetal growth restriction, but also showed long-term effects on learning and memory in the offspring. The caffeine offspring exhibited longer escape latency and path length in navigation testing. The number of passing the target was significantly reduced in those offspring. The expression of adenosine A1 and A2A receptors, nuclear PKA Cα, Cβ subunits, and pCREB were significantly increased in the fetal and neonatal brain, and suppressed in the hippocampus of the adult offspring. The expression of BDNF and TrkB were reduced regardless of various ages. The results suggest that intrauterine programming dysfunction of adenosine receptors and the down-stream of cAMP/PKA/pCREB system may play an important role in prenatal caffeine induced cognition disorders in the adult offspring.

Curcumin Reduces Neuroinflammation and Improves the Impairments of Anesthetics on Learning and Memory by Regulating the Expression of miR-181a-5p

2021 ◽  
pp. 1-9
Author(s):  
Guizhen Liu ◽  
Yuchuan Sun ◽  
Fei Liu
Keyword(s):  
Cognitive Impairment ◽  
Protective Effect ◽  
Learning And Memory ◽  
Cognitive Dysfunction ◽  
Inflammatory Cytokines ◽  
Neuroprotective Effect ◽  
Morris Water Maze Test ◽  
Sprague Dawley ◽  
Protein Levels ◽  
Sprague Dawley Rats

<b><i>Objective:</i></b> The purpose of this study was to explore the role of curcumin (Cur) in isoflurane (ISO)-induced learning and memory dysfunction in Sprague-Dawley rats and further elucidate the mechanism of the protective effect produced by Cur. <b><i>Methods:</i></b> Rat models of cognitive impairment were established by inhaling 3% ISO. The Morris water maze test was used to assess the cognitive function of rats. ELISA and qRT-PCR were used to analyze the protein levels of pro-inflammatory cytokines and expression levels of miR-181a-5p, respectively. <b><i>Results:</i></b> Cur significantly improved the ISO-induced cognitive dysfunction in rats and alleviated the ISO-induced neuroinflammation. miR-181a-5p was overexpressed in ISO-induced rats, while Cur treatment significantly reduced the expression of miR-181a-5p. Overexpression of miR-181a-5p promoted the cognitive impairment and the release of inflammatory cytokines and reversed the neuroprotective effect of Cur. <b><i>Conclusion:</i></b> Cur has a protective effect on ISO-induced cognitive dysfunction, which may be achieved by regulating the expression of miR-181a-5p.

Effects of Preweaning Manganese in Combination with Adult Striatal Dopamine Lesions on Monoamines, BDNF, TrkB, and Cognitive Function in Sprague–Dawley Rats

2019 ◽  
Vol 35 (3) ◽  
pp. 606-620 ◽  
Author(s):  
Rebecca A. Bailey ◽  
Arnold Gutierrez ◽  
Tara L. Kyser ◽  
Ann M. Hemmerle ◽  
Jillian R. Hufgard ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Striatal Dopamine ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Effect of Maternally Administered Methadone on Discrimination Learning of Rat Offspring

1980 ◽  
Vol 50 (3_suppl) ◽  
pp. 1119-1124 ◽  
Author(s):  
Steven Van Wagoner ◽  
Judith Risser ◽  
Marcia Moyer ◽  
David Lasky
Keyword(s):  
Discrimination Learning ◽  
Saline Control ◽  
Control Group ◽  
Shape Discrimination ◽  
Sprague Dawley ◽  
Saline Control Group ◽  
Rat Offspring ◽  
Sprague Dawley Rats ◽  
Methadone Group

Shape discrimination learning by four groups of 150-day-old Sprague-Dawley rats was studied. The groups were the offspring of mothers on the following schedules: (1) prenatal and postnatal methadone, (2) prenatal methadone and postnatal saline, (3) prenatal and postnatal methadone, and (4) prenatal and postnatal saline. The hypothesis investigated was that the methadone groups would show a deficit in learning when compared to the saline-control group. This hypothesis was upheld for the prenatal methadone group and the postnatal methadone group.

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