scholarly journals 3D-printing of transparent bio-microfluidic devices in PEG-DA

Lab on a Chip ◽  
2016 ◽  
Vol 16 (12) ◽  
pp. 2287-2294 ◽  
Author(s):  
Arturo Urrios ◽  
Cesar Parra-Cabrera ◽  
Nirveek Bhattacharjee ◽  
Alan M. Gonzalez-Suarez ◽  
Luis G. Rigat-Brugarolas ◽  
...  
Keyword(s):  
3D Printing ◽  
Microfluidic Devices ◽  
3D Printed

The 3D-printed devices are highly transparent and cells can be cultured on PEG-DA-250 prints for several days.

scholarly journals 3D Printed Microfluidics

2020 ◽  
Vol 13 (1) ◽  
pp. 45-65 ◽  
Author(s):  
Anna V. Nielsen ◽  
Michael J. Beauchamp ◽  
Gregory P. Nordin ◽  
Adam T. Woolley
Keyword(s):  
3D Printing ◽  
Early Stage ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Fabrication Method ◽  
Size Scale ◽  
Additional Work ◽  
Fluidic Devices ◽  
3D Printed ◽  
Microfabrication Techniques

Traditional microfabrication techniques suffer from several disadvantages, including the inability to create truly three-dimensional (3D) architectures, expensive and time-consuming processes when changing device designs, and difficulty in transitioning from prototyping fabrication to bulk manufacturing. 3D printing is an emerging technique that could overcome these disadvantages. While most 3D printed fluidic devices and features to date have been on the millifluidic size scale, some truly microfluidic devices have been shown. Currently, stereolithography is the most promising approach for routine creation of microfluidic structures, but several approaches under development also have potential. Microfluidic 3D printing is still in an early stage, similar to where polydimethylsiloxane was two decades ago. With additional work to advance printer hardware and software control, expand and improve resin and printing material selections, and realize additional applications for 3D printed devices, we foresee 3D printing becoming the dominant microfluidic fabrication method.

scholarly journals Design and characterization of a 3D-printed staggered herringbone mixer

BioTechniques ◽  
2021 ◽  
Author(s):  
Vedika J Shenoy ◽  
Chelsea ER Edwards ◽  
Matthew E Helgeson ◽  
Megan T Valentine
Keyword(s):  
3D Printing ◽  
High Throughput ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Device Design ◽  
Replica Molding ◽  
3D Printed ◽  
And Performance ◽  
To Receive

3D printing holds potential as a faster, cheaper alternative compared with traditional photolithography for the fabrication of microfluidic devices by replica molding. However, the influence of printing resolution and quality on device design and performance has yet to receive detailed study. Here, we investigate the use of 3D-printed molds to create staggered herringbone mixers (SHMs) with feature sizes ranging from ∼100 to 500 μm. We provide guidelines for printer calibration to ensure accurate printing at these length scales and quantify the impacts of print variability on SHM performance. We show that SHMs produced by 3D printing generate well-mixed output streams across devices with variable heights and defects, demonstrating that 3D printing is suitable and advantageous for low-cost, high-throughput SHM manufacturing.

Facilitating Fluid Flow Through Carbon Nanotube Arrays Using 3D Printing

2017 ◽  
Author(s):  
Travis S. Emery ◽  
Anna Jensen ◽  
Koby Kubrin ◽  
Michael G. Schrlau
Keyword(s):  
Carbon Nanotube ◽  
3D Printing ◽  
Microfluidic Device ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Nanotube Arrays ◽  
Nanotube Array ◽  
Cnt Arrays ◽  
3D Printed ◽  
Flow Through

Three-dimensional (3D) printing is a novel technology whose versatility allows it to be implemented in a multitude of applications. Common fabrication techniques implemented to create microfluidic devices, such as photolithography, wet etching, etc., can often times be time consuming, costly, and make it difficult to integrate external components. 3D printing provides a quick and low-cost technique that can be used to fabricate microfluidic devices in a range of intricate geometries. External components, such as nanoporous membranes, can additionally be easily integrated with minimal impact to the component. Here in, low-cost 3D printing has been implemented to create a microfluidic device to enhance understanding of flow through carbon nanotube (CNT) arrays manufactured for gene transfection applications. CNTs are an essential component of nanofluidic research due to their unique mechanical and physical properties. CNT arrays allow for parallel processing however, they are difficult to construct and highly prone to fracture. As a means of aiding in the nanotube arrays’ resilience to fracture and facilitating its integration into fluidic systems, a 3D printed microfluidic device has been constructed around these arrays. Doing so greatly enhances the robustness of the system and additionally allows for the nanotube array to be implemented for a variety of purposes. To broaden their range of application, the devices were designed to allow for multiple isolated inlet flows to the arrays. Utilizing this multiple inlet design permits distinct fluids to enter the array disjointedly. These 3D printed devices were in turn implemented to visualize flow through nanotube arrays. The focus of this report though, is on the design and fabrication of the 3D printed devices. SEM imaging of the completed device shows that the nanotube array remains intact after the printing process and the nanotubes, even those within close proximity to the printing material, remain unobstructed. Printing on top of the nanotube arrays displayed effective adhesion to the surface thus preventing leakage at these interfaces.

scholarly journals Microfluidic devices manufacturing combining stereolithography and pulsed laser ablation

2021 ◽  
Vol 255 ◽  
pp. 12009
Author(s):  
Bastián Carnero ◽  
Carmen Bao-Varela ◽  
Ana Isabel Gómez-Varela ◽  
María Teresa Flores-Arias
Keyword(s):  
Laser Ablation ◽  
3D Printing ◽  
Pulsed Laser ◽  
Pulsed Laser Ablation ◽  
Microfluidic Devices ◽  
Hybrid Technique ◽  
Detailed Surface ◽  
3D Printed ◽  
The One ◽  
User Friendly

3D printing has revolutionized the field of microfluidics manufacturing by simplifying the typical processes offering a considerable accuracy and user-friendly procedures. For its part, laser ablation proves to be a versatile technology to perform detailed surface micropatterning. A hybrid technique that combines both technologies is proposed, employing them in their most suitable range of dimensions. This technique allows to manufacture accurate microfluidics devices as the one proposed: a microchannel, obtained using a stereolithographic printer, coupled with an array of microlenses, obtained by pulsed laser ablation of a 3D printed master.

scholarly journals 3D-Printed Microfluidics and Potential Biomedical Applications

2021 ◽  
Vol 3 ◽  
Author(s):  
Priyanka Prabhakar ◽  
Raj Kumar Sen ◽  
Neeraj Dwivedi ◽  
Raju Khan ◽  
Pratima R. Solanki ◽  
...  
Keyword(s):  
3D Printing ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Microfluidic Devices ◽  
Microfluidic Chips ◽  
3D Printers ◽  
Broad Variety ◽  
3D Printed ◽  
Diagnostic Technologies ◽  
Printing Techniques

3D printing is a smart additive manufacturing technique that allows the engineering of biomedical devices that are usually difficult to design using conventional methodologies such as machining or molding. Nowadays, 3D-printed microfluidics has gained enormous attention due to their various advantages including fast production, cost-effectiveness, and accurate designing of a range of products even geometrically complex devices. In this review, we focused on the recent significant findings in the field of 3D-printed microfluidic devices for biomedical applications. 3D printers are used as fabrication tools for a broad variety of systems for a range of applications like diagnostic microfluidic chips to detect different analytes, for example, glucose, lactate, and glutamate and the biomarkers related to different clinically relevant diseases, for example, malaria, prostate cancer, and breast cancer. 3D printers can print various materials (inorganic and polymers) with varying density, strength, and chemical properties that provide users with a broad variety of strategic options. In this article, we have discussed potential 3D printing techniques for the fabrication of microfluidic devices that are suitable for biomedical applications. Emerging diagnostic technologies using 3D printing as a method for integrating living cells or biomaterials into 3D printing are also reviewed.

scholarly journals Editorial for the Special Issue on 3D Printed Microfluidic Devices

Micromachines ◽  
2018 ◽  
Vol 9 (11) ◽  
pp. 609 ◽  
Author(s):  
Savas Tasoglu ◽  
Albert Folch
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Special Issue ◽  
The Past ◽  
3D Printed

Three-dimensional (3D) printing has revolutionized the microfabrication prototyping workflow over the past few years. [...]

scholarly journals Cell adhesion and proliferation on common 3D printing materials used in stereolithography of microfluidic devices

Lab on a Chip ◽  
2020 ◽  
Vol 20 (13) ◽  
pp. 2372-2382 ◽  
Author(s):  
Kati Piironen ◽  
Markus Haapala ◽  
Virpi Talman ◽  
Päivi Järvinen ◽  
Tiina Sikanen
Keyword(s):  
Cell Adhesion ◽  
3D Printing ◽  
Cell Survival ◽  
Microfluidic Devices ◽  
3D Printed ◽  
Materials Used ◽  
Cell Adhesion And Proliferation

This work reveals the material impacts on long-term cell survival and adhesion on 3D printed surfaces manufactured by stereolithography.

scholarly journals Optical approach to resin formulation for 3D printed microfluidics

RSC Advances ◽  
2015 ◽  
Vol 5 (129) ◽  
pp. 106621-106632 ◽  
Author(s):  
Hua Gong ◽  
Michael Beauchamp ◽  
Steven Perry ◽  
Adam T. Woolley ◽  
Gregory P. Nordin
Keyword(s):  
3D Printing ◽  
Microfluidic Devices ◽  
Size Reduction ◽  
3D Print ◽  
Flow Channels ◽  
Microfluidic Flow ◽  
3D Printed ◽  
Resin Formulation

Custom resin formulation enables 3D printing of much smaller microfluidic flow channels (60 μm × 108 μm) than obtained with commercial 3D printing service bureaus. Such size reduction is a prerequisite to 3D print truly microfluidic devices.

3D printed modules for integrated microfluidic devices

RSC Advances ◽  
2014 ◽  
Vol 4 (62) ◽  
pp. 32876-32880 ◽  
Author(s):  
Kyoung G. Lee ◽  
Kyun Joo Park ◽  
Seunghwan Seok ◽  
Sujeong Shin ◽  
Do Hyun Kim ◽  
...  
Keyword(s):  
3D Printing ◽  
Microfluidic Device ◽  
Microfluidic Devices ◽  
Functional Modules ◽  
3D Printed

Direct 3d printing for functional modules and their assembly into an integrated microfluidic device.

scholarly journals 3D printed microfluidics for biological applications

Lab on a Chip ◽  
2015 ◽  
Vol 15 (18) ◽  
pp. 3627-3637 ◽  
Author(s):  
Chee Meng Benjamin Ho ◽  
Sum Huan Ng ◽  
King Ho Holden Li ◽  
Yong-Jin Yoon
Keyword(s):  
3D Printing ◽  
Microfluidic Devices ◽  
Biological Applications ◽  
The Future ◽  
3D Printed

In this paper, a review is carried out of how 3D printing helps to improve the fabrication of microfluidic devices, the 3D printing technologies currently used for fabrication and the future of 3D printing in the field of microfluidics.

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