Synthetic ultra-long chain fatty acyl based amphiphilic lipids as a dual function excipient for the production of surfactant-free solid lipid nanoparticles (SF-SLNs): a physico-chemical study

2016 ◽  
Vol 18 (14) ◽  
pp. 3962-3971 ◽  
Author(s):  
Wei Wei ◽  
Xiaonan Lu ◽  
Zegao Wang ◽  
Mingdong Dong ◽  
Fengqin Feng ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Chemical Study ◽  
Lipid Nanoparticles ◽  
Fatty Acyl ◽  
Dual Function ◽  
Solid Lipid ◽  
Physico Chemical ◽  
Long Chain

Behenoyl (22 : 0) based amphiphilic lipids are synthesized, some of which demonstrate excellent dual functionality as both solid excipients and emulsifiers in producing uniform solid lipid nanoparticles (SLNs).

scholarly journals Correction: Synthetic ultra-long chain fatty acyl based amphiphilic lipids as a dual function excipient for the production of surfactant-free solid lipid nanoparticles (SF-SLNs): a physico-chemical study

2016 ◽  
Vol 18 (15) ◽  
pp. 4312-4312
Author(s):  
Wei Wei ◽  
Xiaonan Lu ◽  
Zegao Wang ◽  
Mingdong Dong ◽  
Fengqin Feng ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Chemical Study ◽  
Lipid Nanoparticles ◽  
Fatty Acyl ◽  
Dual Function ◽  
Solid Lipid ◽  
Physico Chemical ◽  
Long Chain

Correction for ‘Synthetic ultra-long chain fatty acyl based amphiphilic lipids as a dual function excipient for the production of surfactant-free solid lipid nanoparticles (SF-SLNs): a physico-chemical study’ by Wei Wei et al., Green Chem., 2016, DOI: 10.1039/c6gc00866f.

Tailored rigidity of W/O Pickering emulsions using diacylglycerol-based surface-active solid lipid nanoparticles

2021 ◽  
Author(s):  
Guoyan Li ◽  
Wan Jun Lee ◽  
Chin Ping Tan ◽  
Oi-Ming Lai ◽  
Yong Wang ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Colloidal Stability ◽  
Lipid Nanoparticles ◽  
Pickering Emulsions ◽  
Solid Lipid ◽  
Surface Active ◽  
Long Chain

Pickering water-in-oil (W/O) emulsions were fabricated by using medium-long chain diacylglycerol (MLCD)-based solid lipid nanoparticles (SLNs) and the connection between the characteristics of the SLNs and the colloidal stability of...

scholarly journals Cyto/Biocompatibility of Dopamine Combined with the Antioxidant Grape Seed-Derived Polyphenol Compounds in Solid Lipid Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 916
Author(s):  
Adriana Trapani ◽  
Lorenzo Guerra ◽  
Filomena Corbo ◽  
Stefano Castellani ◽  
Enrico Sanna ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Chemical Characterization ◽  
Grape Seed ◽  
Lipid Nanoparticles ◽  
Non Invasive ◽  
Solid Lipid ◽  
Physico Chemical ◽  
Release Studies ◽  
Nigrostriatal Neurons ◽  
6 Hydroxydopamine

Background: The loss of nigrostriatal neurons containing dopamine (DA) together with the “mitochondrial dysfunction” in midbrain represent the two main causes related to the symptoms of Parkinson’s disease (PD). Hence, the aim of this investigation is to co-administer the missing DA and the antioxidant grape seed-derived proanthocyanidins (grape seed extract, GSE) in order to increase the levels of the neurotransmitter (which is unable to cross the Blood Brain Barrier) and reducing the oxidative stress (OS) related to PD, respectively. Methods: For this purpose, we chose Solid Lipid Nanoparticles (SLN), because they have been already proven to increase DA uptake in the brain. DA-SLN adsorbing GSE (GSE/DA-SLN) were formulated and subjected to physico-chemical characterization, and their cytocompatibility and protection against OS were examined. Results: GSE was found on SLN surface and release studies evidenced the efficiency of GSE in preventing DA autoxidation. Furthermore, SLN showed high mucoadhesive strength and were found not cytotoxic to both primary Olfactory Ensheathing and neuroblastoma SH-SY5Y cells by MTT test. Co-administration of GSE/DA-SLN and the OS-inducing neurotoxin 6-hydroxydopamine (100 μM) resulted in an increase of SH-SY5Y cell viability. Conclusions: Hence, SLN formulations containing DA and GSE may constitute interesting candidates for non-invasive nose-to-brain delivery.

Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles

2009 ◽  
Vol 00 (00) ◽  
pp. 090820062440031-9 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Mohsen Minayian ◽  
Elaheh Moazen
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development and optimization of solid lipid nanoparticles of amikacin by central composite design

2009 ◽  
Vol 00 (00) ◽  
pp. 090721051030036-8
Author(s):  
Jaleh Varshosaz ◽  
Solmaz Ghaffari ◽  
Mohammad Reza Khoshayand ◽  
Fatemeh Atyabi ◽  
Shirzad Azarmi ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Central Composite

Solid lipid nanoparticles for oral delivery of curcumin

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
C Righeschi ◽  
M Bergonzi ◽  
B Isacchi ◽  
A Bilia
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

2009 ◽  
Vol 1 (1) ◽  
Author(s):  
Pravin Patil ◽  
Anil Sharma ◽  
Subhash Dadarwal ◽  
Vijay Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Rotation Speed ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Brain Penetration ◽  
Solid Lipid ◽  
Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

Sign in / Sign up

Export Citation Format

Share Document