Aloe activated P-glycoprotein and CYP 3A: a study on the serum kinetics of aloe and its interaction with cyclosporine in rats

2017 ◽  
Vol 8 (1) ◽  
pp. 315-322 ◽  
Author(s):  
Meng-Syuan Yang ◽  
Chung-Ping Yu ◽  
Ching-Ya Huang ◽  
Pei-Dawn Lee Chao ◽  
Shiuan-Pey Lin ◽  
...  
Keyword(s):  
Functional Food ◽  
Aloe Vera ◽  
P Glycoprotein ◽  
Kinetics Of ◽  
Cyp 3A ◽  
Leaf Juice

Aloe, the leaf juice ofAloe vera, is a popular functional food worldwide.

Kinetics of the multidrug transporter (P-glycoprotein) and its reversal

1997 ◽  
Vol 77 (2) ◽  
pp. 545-590 ◽  
Author(s):  
W. D. Stein
Keyword(s):  
Final Section ◽  
Transport Kinetics ◽  
Multidrug Transporter ◽  
Chemotherapeutic Drugs ◽  
Multidrug Resistance Proteins ◽  
Binding Properties ◽  
Membrane Pump ◽  
Resistance Proteins ◽  
P Glycoprotein ◽  
Kinetics Of

Most cancer deaths result from the cancer's either being intrinsically resistant to chemotherapeutic drugs or becoming resistant after being initially sensitive. Often, in cells grown in cell culture, drug resistance correlates with the presence of one or more of the so-called P-glycoproteins or multidrug resistance proteins, products of the mdr family of genes. This review is largely concerned with the transport kinetics of the P-glycoproteins. We first present a brief overview of the P-glycoproteins, their properties, and their clinical significance. Later sections of the review expand on this material with special emphasis on the substrates of P-glycoprotein and how they cross the cell membrane, on the transport kinetics of the P-glycoprotein, on reversers of its action, and on its activity as an ATPase. In a final section, we consider the mechanism of action of P-glycoprotein as an actively transporting membrane pump. The characteristic of P-glycoprotein considered the most difficult to explain is its very broad specificity (or lack of specificity), but there are precedents for this property in well-known proteins such as serum albumin, which binds a range of molecular types, including substrates and reversers of P-glycoprotein, seemingly as broad as does P-glycoprotein. Pointing out this analogy does not provide a molecular explanation for the substrate-binding properties of P-glycoprotein but does make those properties more assimilable.

Biphasic accumulation kinetics of [99mTc]-hexakis-2-methoxyisobutyl isonitrile in tumour cells and its modulation by lipophilic P-glycoprotein ligands

2005 ◽  
Vol 25 (2-3) ◽  
pp. 201-209 ◽  
Author(s):  
Teréz Márián ◽  
László Balkay ◽  
Gábor Szabó ◽  
Zoárd T. Krasznai ◽  
Zoltán Hernádi ◽  
...  
Keyword(s):  
Tumour Cells ◽  
P Glycoprotein ◽  
Accumulation Kinetics ◽  
Kinetics Of

scholarly journals Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?

2010 ◽  
Vol 15 (7) ◽  
pp. 975-983 ◽  
Author(s):  
Alexander Jetter ◽  
Gerd Fätkenheuer ◽  
Dorothee Frank ◽  
Tobias Klaassen ◽  
Angela Seeringer ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Healthy Volunteers ◽  
P Glycoprotein ◽  
Cyp 3A
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