scholarly journals Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women

2016 ◽  
Vol 7 (5) ◽  
pp. 2197-2203 ◽  
Author(s):  
Natalie C. Ward ◽  
Jonathan M. Hodgson ◽  
Richard J. Woodman ◽  
Diane Zimmermann ◽  
Laure Poquet ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelial Function ◽  
Rich Source ◽  
Chlorogenic Acids ◽  
Acute Effects ◽  
Men And Women ◽  
Healthy Men

Coffee is a rich source of polyphenols, primarily chlorogenic acids (CGA).

scholarly journals Age-Associated Changes in Blood Pressure in a Longitudinal Study of Healthy Men and Women

1997 ◽  
Vol 52A (3) ◽  
pp. M177-M183 ◽  
Author(s):  
J. D. Pearson ◽  
C. H. Morrell ◽  
L. J. Brant ◽  
P. K. Landis ◽  
J. L. Fleg
Keyword(s):  
Blood Pressure ◽  
Longitudinal Study ◽  
Men And Women ◽  
Healthy Men

Effect of adding milk to black tea on vascular function in healthy men and women: a randomised controlled crossover trial

2018 ◽  
Vol 9 (12) ◽  
pp. 6307-6314 ◽  
Author(s):  
Adilah F. Ahmad ◽  
Lisa Rich ◽  
Henrietta Koch ◽  
Kevin D. Croft ◽  
Mario G. Ferruzzi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vascular Function ◽  
Crossover Trial ◽  
Black Tea ◽  
Tea Consumption ◽  
Short Term ◽  
Men And Women ◽  
Healthy Men ◽  
Randomised Controlled ◽  
P Addition

Addition of milk to black tea alters the acute/short-term benefical effect of regular black tea consumption on vascular function and blood pressure.

scholarly journals Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study

2015 ◽  
Vol 114 (8) ◽  
pp. 1246-1255 ◽  
Author(s):  
Roberto Sansone ◽  
Ana Rodriguez-Mateos ◽  
Jan Heuel ◽  
David Falk ◽  
Dominik Schuler ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Pulse Wave Velocity ◽  
Endothelial Function ◽  
Cardiovascular Health ◽  
Framingham Risk Score ◽  
Pulse Wave ◽  
Men And Women ◽  
Framingham Risk ◽  
Randomised Controlled

AbstractCocoa flavanol (CF) intake improves endothelial function in patients with cardiovascular risk factors and disease. We investigated the effects of CF on surrogate markers of cardiovascular health in low risk, healthy, middle-aged individuals without history, signs or symptoms of CVD. In a 1-month, open-label, one-armed pilot study, bi-daily ingestion of 450 mg of CF led to a time-dependent increase in endothelial function (measured as flow-mediated vasodilation (FMD)) that plateaued after 2 weeks. Subsequently, in a randomised, controlled, double-masked, parallel-group dietary intervention trial (Clinicaltrials.gov: NCT01799005), 100 healthy, middle-aged (35–60 years) men and women consumed either the CF-containing drink (450 mg) or a nutrient-matched CF-free control bi-daily for 1 month. The primary end point was FMD. Secondary end points included plasma lipids and blood pressure, thus enabling the calculation of Framingham Risk Scores and pulse wave velocity. At 1 month, CF increased FMD over control by 1·2 % (95 % CI 1·0, 1·4 %). CF decreased systolic and diastolic blood pressure by 4·4 mmHg (95 % CI 7·9, 0·9 mmHg) and 3·9 mmHg (95 % CI 6·7, 0·9 mmHg), pulse wave velocity by 0·4 m/s (95 % CI 0·8, 0·04 m/s), total cholesterol by 0·20 mmol/l (95 % CI 0·39, 0·01 mmol/l) and LDL-cholesterol by 0·17 mmol/l (95 % CI 0·32, 0·02 mmol/l), whereas HDL-cholesterol increased by 0·10 mmol/l (95 % CI 0·04, 0·17 mmol/l). By applying the Framingham Risk Score, CF predicted a significant lowering of 10-year risk for CHD, myocardial infarction, CVD, death from CHD and CVD. In healthy individuals, regular CF intake improved accredited cardiovascular surrogates of cardiovascular risk, demonstrating that dietary flavanols have the potential to maintain cardiovascular health even in low-risk subjects.

Renal extraction and acute effects of glucagon-like peptide-1 on central and renal hemodynamics in healthy men

2015 ◽  
Vol 308 (8) ◽  
pp. E641-E649 ◽  
Author(s):  
Ali Asmar ◽  
Lene Simonsen ◽  
Meena Asmar ◽  
Sten Madsbad ◽  
Jens J. Holst ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cardiac Output ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Renal Hemodynamics ◽  
Acute Effects ◽  
Primary Metabolite ◽  
Healthy Men ◽  
Glucagon Like Peptide

The present experiments were performed to elucidate the acute effects of intravenous infusion of glucagon-like peptide (GLP)-1 on central and renal hemodynamics in healthy men. Seven healthy middle-aged men were examined on two different occasions in random order. During a 3-h infusion of either GLP-1 (1.5 pmol·kg−1·min−1) or saline, cardiac output was estimated noninvasively, and intraarterial blood pressure and heart rate were measured continuously. Renal plasma flow, glomerular filtration rate, and uptake/release of hormones and ions were measured by Fick's Principle after catheterization of a renal vein. Subjects remained supine during the experiments. During GLP-1 infusion, both systolic blood pressure and arterial pulse pressure increased by 5 ± 1 mmHg ( P = 0.015 and P = 0.002, respectively). Heart rate increased by 5 ± 1 beats/min ( P = 0.005), and cardiac output increased by 18% ( P = 0.016). Renal plasma flow and glomerular filtration rate as well as the clearance of Na+ and Li+ were not affected by GLP-1. However, plasma renin activity decreased ( P = 0.037), whereas plasma levels of atrial natriuretic peptide were unaffected. Renal extraction of intact GLP-1 was 43% ( P < 0.001), whereas 60% of the primary metabolite GLP-1 9-36amide was extracted ( P = 0.017). In humans, an acute intravenous administration of GLP-1 leads to increased cardiac output due to a simultaneous increase in stroke volume and heart rate, whereas no effect on renal hemodynamics could be demonstrated despite significant extraction of both the intact hormone and its primary metabolite.

scholarly journals Acute effects of ingestion of a novel whey‐derived extract on vascular endothelial function in middle‐aged men and women

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Kevin D. Ballard ◽  
Brian R. Kupchak ◽  
Brittanie M. Volk ◽  
Eunice Mah ◽  
Aida Shkreta ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Vascular Endothelial ◽  
Acute Effects ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
Men And Women
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