Partially hydrolyzed guar gum enhances colonic epithelial wound healing via activation of RhoA and ERK1/2

2016 ◽  
Vol 7 (7) ◽  
pp. 3176-3183 ◽  
Author(s):  
Yusuke Horii ◽  
Kazuhiko Uchiyama ◽  
Yuki Toyokawa ◽  
Yuma Hotta ◽  
Makoto Tanaka ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epithelial Cell ◽  
Guar Gum ◽  
Colonic Epithelial Cell ◽  
Epithelial Wound Healing ◽  
Partially Hydrolyzed Guar Gum

We provide evidence that partially hydrolyzed guar gum (PHGG) enhances colonic epithelial cell wound healing.

Promotion of wound healing by acetate in murine colonic epithelial cell via c‐Jun N‐terminal kinase activation

2020 ◽  
Vol 35 (7) ◽  
pp. 1171-1179 ◽  
Author(s):  
Takahiro Nakano ◽  
Kazuhiko Uchiyama ◽  
Chihiro Ushiroda ◽  
Saori Kashiwagi ◽  
Yuki Toyokawa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epithelial Cell ◽  
Colonic Epithelial Cell ◽  
Kinase Activation

scholarly journals A Role for the Mitogen-activated Protein Kinase Kinase Kinase 1 in Epithelial Wound Healing

2006 ◽  
Vol 17 (8) ◽  
pp. 3446-3455 ◽  
Author(s):  
Maoxian Deng ◽  
Wei-Li Chen ◽  
Atsushi Takatori ◽  
Zhimin Peng ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cell Migration ◽  
Epithelial Cell ◽  
Skin Wound ◽  
Mitogen Activated Protein Kinase ◽  
Epithelial Cell Migration ◽  
Epithelial Wound Healing ◽  
Mitogen Activated Protein ◽  
Pai 1 ◽  
Protein Kinase Kinase

The mitogen-activated protein kinase kinase (MEK) kinase 1 (MEKK1) mediates activin B signals required for eyelid epithelium morphogenesis during mouse fetal development. The present study investigates the role of MEKK1 in epithelial wound healing, another activin-regulated biological process. In a skin wound model, injury markedly stimulates MEKK1 expression and activity, which are in turn required for the expression of genes involved in extracellular matrix (ECM) homeostasis. MEKK1 ablation or down-regulation by interfering RNA significantly delays skin wound closure and impairs activation of Jun NH2-terminal kinases, induction of plasminogen activator inhibitor (PAI)-1, and restoration of cell–cell junctions of the wounded epidermis. Conversely, expression of wild-type MEKK1 accelerates reepithelialization of full-thickness skin and corneal debridement wounds by mechanisms involving epithelial cell migration, a cell function that is partially abolished by neutralizing antibodies for PAI-1 and metalloproteinase III. Our data suggest that MEKK1 transmits wound signals, leading to the transcriptional activation of genes involved in ECM homeostasis, epithelial cell migration, and wound reepithelialization.

The role of vesicle trafficking in epithelial cell motility

2009 ◽  
Vol 37 (5) ◽  
pp. 1072-1076 ◽  
Author(s):  
Sarah J. Fletcher ◽  
Joshua Z. Rappoport
Keyword(s):  
Wound Healing ◽  
Epithelial Cell ◽  
Cell Motility ◽  
Cancer Metastasis ◽  
Endosomal Recycling ◽  
Epithelial Cell Migration ◽  
Polarized Trafficking ◽  
Epithelial Wound Healing ◽  
Relevant Topic

Cell motility is important for many physiological and pathological processes including organ development, wound healing, cancer metastasis and correct immune responses. In particular, epithelial wound healing is both a medically relevant topic and a common experimental model. Mechanisms underlying generation of a polarized cell and maintenance of a motile phenotype during steady-state migration are not well understood. Polarized trafficking of bulk membrane and cell adhesion molecules has been implicated in regulation of cell motility. The present review focuses on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, ‘short-loop’ and ‘long-loop’ endosomal recycling.

Tu1296 BILE ACIDS DELAY THE WOUND HEALING OF COLONIC EPITHELIAL CELL THROUGH TRANSMEMBRANE G-PROTEIN-COUPLED RECEPTOR 5

2020 ◽  
Vol 158 (6) ◽  
pp. S-1047-S-1048
Author(s):  
Yuka Azuma ◽  
Kazuhiko Uchiyama ◽  
Mariko Kajiwara ◽  
Satoshi Sugino ◽  
Hiroaki Kitae ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epithelial Cell ◽  
Bile Acids ◽  
G Protein ◽  
Colonic Epithelial Cell ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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