scholarly journals Current detection technologies for circulating tumor cells

2017 ◽  
Vol 46 (8) ◽  
pp. 2038-2056 ◽  
Author(s):  
Zheyu Shen ◽  
Aiguo Wu ◽  
Xiaoyuan Chen
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Cancer Recurrence ◽  
Early Cancer Diagnosis ◽  
Chemotherapeutic Efficacy ◽  
Anti Cancer ◽  
Current Detection ◽  
Detection Technologies

CTC detection can be used for early cancer diagnosis, earlier evaluation of cancer recurrence and chemotherapeutic efficacy, and choice of individual sensitive anti-cancer drugs.

Nanotopographic Biomaterials for Isolation of Circulating Tumor Cells

2014 ◽  
Vol 5 (4) ◽  
Author(s):  
Weiyi Qian ◽  
Yan Zhang ◽  
Andrew Gordon ◽  
Weiqiang Chen
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Diagnosis ◽  
Cancer Metastasis ◽  
Early Cancer ◽  
Tumor Mass ◽  
Early Cancer Diagnosis ◽  
Capture And Release ◽  
Increasing Demand ◽  
Detection Technologies

Circulating tumor cells (CTCs) shed from the primary tumor mass and circulating in the bloodstream of patients are believed to be vital to understand of cancer metastasis and progression. Capture and release of CTCs for further enumeration and molecular characterization holds the key for early cancer diagnosis, prognosis and therapy evaluation. However, detection of CTCs is challenging due to their rarity, heterogeneity and the increasing demand of viable CTCs for downstream biological analysis. Nanotopographic biomaterial-based microfluidic systems are emerging as promising tools for CTC capture with improved capture efficiency, purity, throughput and retrieval of viable CTCs. This review offers a brief overview of the recent advances in this field, including CTC detection technologies based on nanotopographic biomaterials and relevant nanofabrication methods. Additionally, the possible intracellular mechanisms of the intrinsic nanotopography sensitive responses that lead to the enhanced CTC capture are explored.

Engineered red blood cells for capturing circulating tumor cells with high performance

Nanoscale ◽  
2018 ◽  
Vol 10 (13) ◽  
pp. 6014-6023 ◽  
Author(s):  
Dao-Ming Zhu ◽  
Lei Wu ◽  
Meng Suo ◽  
Song Gao ◽  
Wei Xie ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Diagnosis ◽  
Peripheral Blood ◽  
Blood Cells ◽  
High Performance ◽  
Early Cancer ◽  
Treatment Monitoring ◽  
Prognostic Evaluation ◽  
Early Cancer Diagnosis

Filtration of circulating tumor cells (CTCs) in peripheral blood is of proven importance for early cancer diagnosis, treatment monitoring, metastasis diagnosis, and prognostic evaluation.

scholarly journals Nanotechnology-Based Strategies for Early Cancer Diagnosis Using Circulating Tumor Cells as a Liquid Biopsy

2018 ◽  
Vol 2 (1) ◽  
pp. 21-41 ◽  
Author(s):  
Qinqin Huang ◽  
Yin Wang ◽  
Xingxiang Chen ◽  
Yimeng Wang ◽  
Zhiqiang Li ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Diagnosis ◽  
Liquid Biopsy ◽  
Early Cancer ◽  
Early Cancer Diagnosis

High Sensitivity Detection of Tumor Cells in Biological Samples using Multivalent Aptamer Strand Displacement Strategy

The Analyst ◽  
2022 ◽  
Author(s):  
Jieru Xu ◽  
Jiahui Xiang ◽  
Jialing Chen ◽  
Tao Wan ◽  
Hongli Deng ◽  
...  
Keyword(s):  
Cell Surface ◽  
Tumor Cells ◽  
Cancer Diagnosis ◽  
Biological Samples ◽  
Cell Membranes ◽  
Early Cancer ◽  
High Sensitivity ◽  
Strand Displacement ◽  
Early Cancer Diagnosis ◽  
High Sensitivity Detection

Monitoring the cell surface-expressed nucleolin facilitates early cancer diagnosis. Herein, we developed multivalent aptamer displacement strand duplex strategy on the cell membranes utilizing a multi-receptor co-recognition design for improving sensitivity...

scholarly journals Circulating Tumor Cells from Enumeration to Analysis: Current Challenges and Future Opportunities

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2723
Author(s):  
Yu-Ping Yang ◽  
Teresa M. Giret ◽  
Richard J. Cote
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Ex Vivo ◽  
Detection Sensitivity ◽  
Clinical Utilization ◽  
Diagnosis And Prognosis ◽  
Early Cancer Diagnosis ◽  
Potential Marker ◽  
Potential Applications ◽  
Downstream Analysis

Circulating tumor cells (CTCs) have been recognized as a major contributor to distant metastasis. Their unique role as metastatic seeds renders them a potential marker in the circulation for early cancer diagnosis and prognosis as well as monitoring of therapeutic response. In the past decade, researchers mainly focused on the development of isolation techniques for improving the recovery rate and purity of CTCs. These developed techniques have significantly increased the detection sensitivity and enumeration accuracy of CTCs. Currently, significant efforts have been made toward comprehensive molecular characterization, ex vivo expansion of CTCs, and understanding the interactions between CTCs and their associated cells (e.g., immune cells and stromal cells) in the circulation. In this review, we briefly summarize existing CTC isolation technologies and specifically focus on advances in downstream analysis of CTCs and their potential applications in precision medicine. We also discuss the current challenges and future opportunities in their clinical utilization.

scholarly journals Gene Expression Correlation for Cancer Diagnosis: A Pilot Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Binbing Ling ◽  
Lifeng Chen ◽  
Qiang Liu ◽  
Jian Yang
Keyword(s):  
Pilot Study ◽  
Cancer Progression ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Correlation Coefficients ◽  
Gene Expressions ◽  
Clinical Biomarkers ◽  
Biomolecular Networks ◽  
Early Cancer Diagnosis ◽  
Novel Strategy

Poor prognosis for late-stage, high-grade, and recurrent cancers has been motivating cancer researchers to search for more efficient biomarkers to identify the onset of cancer. Recent advances in constructing and dynamically analyzing biomolecular networks for different types of cancer have provided a promising novel strategy to detect tumorigenesis and metastasis. The observation of different biomolecular networks associated with normal and cancerous states led us to hypothesize that correlations for gene expressions could serve as valid indicators of early cancer development. In this pilot study, we tested our hypothesis by examining whether the mRNA expressions of three randomly selected cancer-related genesPIK3C3,PIM3, andPTENwere correlated during cancer progression and the correlation coefficients could be used for cancer diagnosis. Strong correlations(0.68≤r≤1.0)were observed betweenPIK3C3andPIM3in breast cancer, betweenPIK3C3andPTENin breast and ovary cancers, and betweenPIM3andPTENin breast, kidney, liver, and thyroid cancers during disease progression, implicating that the correlations for cancer network gene expressions could serve as a supplement to current clinical biomarkers, such as cancer antigens, for early cancer diagnosis.

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