Chemoselective reduction of carboxamides

2016 ◽  
Vol 45 (24) ◽  
pp. 6685-6697 ◽  
Author(s):  
Alexey Volkov ◽  
Fredrik Tinnis ◽  
Tove Slagbrand ◽  
Paz Trillo ◽  
Hans Adolfsson
Keyword(s):  
Amide Reduction

This tutorial review presents the most prominent protocols developed for chemoselective amide reduction.

Twisted Amide Reduction under Wolff−Kishner Conditions:  Synthesis of a Benzo-1-Aza-Adamantane Derivative

2003 ◽  
Vol 125 (11) ◽  
pp. 3268-3272 ◽  
Author(s):  
Crystal G. Bashore ◽  
Ivan J. Samardjiev ◽  
Jon Bordner ◽  
Jotham W. Coe
Keyword(s):  
Adamantane Derivative ◽  
Amide Reduction

A comparative analysis of hydrosilative amide reduction catalyzed by first-row transition metal (Mn, Fe, Co, and Ni) N-phosphinoamidinate complexes

2019 ◽  
Vol 48 (26) ◽  
pp. 9581-9587 ◽  
Author(s):  
Casper M. Macaulay ◽  
Takahiko Ogawa ◽  
Robert McDonald ◽  
Orson L. Sydora ◽  
Mark Stradiotto ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Transition Metal ◽  
Mild Conditions ◽  
Amide Reduction

Screening reveals (PN)Ni(x) pre-catalysts to be effective for the hydrosilative reduction of amides under mild conditions.

Tritium labelling of bromhexine via amide reduction with LiB3H4

2005 ◽  
Vol 48 (6) ◽  
pp. 429-434
Author(s):  
Uffe S. Larsen ◽  
Mikael Begtrup ◽  
Lars Martiny
Keyword(s):  
Amide Reduction

Biocatalytic Amide Reduction Using Clostridium sporogenes

2005 ◽  
Vol 27 (22) ◽  
pp. 1803-1807 ◽  
Author(s):  
Olutosin Dipeolu ◽  
John Gardiner ◽  
Gill Stephens
Keyword(s):  
Clostridium Sporogenes ◽  
Amide Reduction

scholarly journals The importance of the counter-cation in reductive rare-earth metal chemistry: 18-crown-6 instead of 2,2,2-cryptand allows isolation of [YII(NR2)3]1− and ynediolate and enediolate complexes from CO reactions

2020 ◽  
Vol 11 (7) ◽  
pp. 2006-2014 ◽  
Author(s):  
Austin J. Ryan ◽  
Joseph W. Ziller ◽  
William J. Evans
Keyword(s):  
Rare Earth ◽  
Rare Earth Metal ◽  
Earth Metal ◽  
Reduction Reactions ◽  
Metal Chemistry ◽  
Counter Cation ◽  
Amide Reduction ◽  
Co Reduction

The use of 18-crown-6 (18-c-6) in place of 2.2.2-cryptand (crypt) in rare earth amide reduction reactions involving potassium has proven to be crucial in the synthesis of Ln(ii) complexes and isolation of their CO reduction products.

A BEt3-Base Catalyst for Amide Reduction with Silane

2019 ◽  
Vol 84 (10) ◽  
pp. 6084-6093 ◽  
Author(s):  
Wubing Yao ◽  
Huaquan Fang ◽  
Qiaoxing He ◽  
Dongjie Peng ◽  
Guixia Liu ◽  
...  
Keyword(s):  
Base Catalyst ◽  
Amide Reduction

scholarly journals Reductive Functionalization of Amides in Synthesis and for Modification of Bioactive Compounds

2021 ◽  
Vol 9 ◽  
Author(s):  
Paweł J. Czerwiński ◽  
Bartłomiej Furman
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Late Stage ◽  
Main Axis ◽  
Synthetic Approach ◽  
Condensed Form ◽  
Amide Reduction ◽  
Synthetic Application

In this review, applications of the amide reductive functionalization methodology for the synthesis and modification of bioactive compounds are covered. A brief summary of the different protocols is presented in the introduction, followed by the synthetic application of these in late-stage functionalization, leading to known pharmaceuticals or to their derivatives, including bioisosteres, with potential higher activity as the main axis of the article. The synthetic approach to natural products based on amide reduction is also discussed; however, this is given in a condensed form focusing on recent or as yet unexplored applications due to a number of recently published excellent reviews covering this topic. The aim of this review is to illustrate the potential of reductive functionalization of amides as an elegant and useful tool in the synthesis of bioactive compounds and inspire further work in this field.

scholarly journals Site Selective Amide Reduction of Cyclosporine A Enables Diverse Derivation of an Important Cyclic Peptide

2019 ◽  
Vol 21 (9) ◽  
pp. 3451-3455 ◽  
Author(s):  
Michael T. Peruzzi ◽  
Fabrice Gallou ◽  
Stephen J. Lee ◽  
Michel R. Gagné
Keyword(s):  
Cyclosporine A ◽  
Cyclic Peptide ◽  
Amide Reduction ◽  
Site Selective
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