Twisted Amide Reduction under Wolff−Kishner Conditions:  Synthesis of a Benzo-1-Aza-Adamantane Derivative

2003 ◽  
Vol 125 (11) ◽  
pp. 3268-3272 ◽  
Author(s):  
Crystal G. Bashore ◽  
Ivan J. Samardjiev ◽  
Jon Bordner ◽  
Jotham W. Coe
Keyword(s):  
Adamantane Derivative ◽  
Amide Reduction

scholarly journals Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

2013 ◽  
Vol 4 (8) ◽  
pp. 704-709 ◽  
Author(s):  
Claudio Battilocchio ◽  
Lucie Guetzoyan ◽  
Chiara Cervetto ◽  
Lorenzo Di Cesare Mannelli ◽  
Daniela Frattaroli ◽  
...  
Keyword(s):  
Glutamate Release ◽  
Adamantane Derivative ◽  
Flow Synthesis ◽  
Biological Studies

scholarly journals THE CLINICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THE CORRECTION OF POSTENCEPHALITIC SOMATOGENIC ASTHENIA

2013 ◽  
Vol 18 (4) ◽  
pp. 15-19
Author(s):  
O. N Sumlivaya ◽  
N. N Vorobiova ◽  
Yu. V Karakulova ◽  
E. L Veselova ◽  
O. V Shalaeva ◽  
...  
Keyword(s):  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Subjective Evaluation ◽  
Depression Scale ◽  
Adamantane Derivative ◽  
Adamantane Derivatives ◽  
Randomized Clinical Study ◽  
Tick Borne Encephalitis ◽  
Autonomic Changes ◽  
Daily Dose

An open, randomized clinical study in two groups of reconvalescents of tick-borne encephalitis suffered from postencefalitic somatogenetic asthenia. The first group was consisted of 14 patients who received adamantane derivatives - ladasten at a daily dose of 100 mg for 25 days. The second comparison group included 18 convalescents who were followed up without an prescription of Ladasten. Before and after treatment, the examination with the use of a Visual Analogue Scale fatigue, scale of subjective evaluation fatigue - Multidimensional Fatigue Inventory (MFI-20), Beck Depression Inventory, D. Spielberger's test (State-Trate-Anxiety-Inventory (STAI)), adapted for Russia by Yu. L. Khanin, a questionnaire for detection signs of autonomic changes. After receiving ladasten patients showed significant dynamics of the drop in scores accordingly to visual analogue scale fatigue by 2.5 times as opposed to those in the second group, where the fall was only by 1.4 times. In the first group there were also significant fall in scores of all scales MFI-20 (p = 0.0001), Beck Depression Scale (p = 0.001), Spielberger-Khanin test (p = 0.002) and the questionnaire for evidence of autonomic changes (p = 0.001). The obtained data suggest that Ladasten at a daily dose of 100 mg is highly effective drug with antifatigue, anxiolytic and vegetostabilizing effects and can be recommended in rehabilitation period to patients after the tick-borne encephalitis with manifestations of postencefalitic somatogenetic asthenia.

Inhibition of myocardial K+ channels by bromobenzoyl-methyladamantylamine, an adamantane derivative

1982 ◽  
Vol 84 (3-4) ◽  
pp. 151-160 ◽  
Author(s):  
János Mészáros ◽  
Károly Kelemen ◽  
Raisa Markó ◽  
Valéria Kecskeméti ◽  
József Szegi
Keyword(s):  
Adamantane Derivative ◽  
K Channels

In vitro Controlled Release of two new Tuberculocidal Adamantane Aminoethers from Solid Pharmaceutical Formulations (II)

Drug Research ◽  
2017 ◽  
Vol 67 (11) ◽  
pp. 653-660 ◽  
Author(s):  
Marilena Vlachou ◽  
Angeliki Siamidi ◽  
Dimitrios Spaneas ◽  
Dimitrios Lentzos ◽  
Polixeni Ladia ◽  
...  
Keyword(s):  
Controlled Release ◽  
In Vitro Release ◽  
Pharmaceutical Formulations ◽  
Adamantane Derivative ◽  
In Vivo Studies ◽  
Matrix Tablet ◽  
The Us ◽  
Vitro Release

AbstractThe aim of the present investigation was to develop matrix tablet formulations for the in vitro controlled release of two new tuberculocidal adamantane aminoethers (compounds III and IV), congeneric to the adamantane derivative SQ109, which is in final clinical trials, and aminoethers (I) and (II), using carefully selected excipients, such as polyvinylpyrrolidone, sodium alginate and lactose. The tablets were prepared using the direct compression method and dissolution experiments were conducted using the US Pharmacopoeia type II apparatus (paddle method) in gastric and intestinal fluids. The results suggest that both analogues, albeit more lipophilic than SQ109, and aminoethers (I) and (II), have the requisite in vitro release characteristics for oral administration. In conclusion, these formulations merit further assessment by conducting in vivo studies, at a later stage.

Adamantane Derivative as Host Material for Efficient Deep-Blue Phosphorescent Organic Light Emitting Diodes

2009 ◽  
Vol 1212 ◽  
Author(s):  
Hirohiko Fukagawa ◽  
Norimasa Yokoyama ◽  
Shiro Irisa ◽  
Shizuo Tokito
Keyword(s):  
Electron Mobility ◽  
Power Efficiency ◽  
High Efficiency ◽  
Adamantane Derivative ◽  
Host Material ◽  
High Electron ◽  
Light Emitting ◽  
Deep Blue ◽  
Organic Light ◽  
Blue Phosphorescent

AbstractWe report on a high efficiency deep-blue phosphorescent organic light-emitting diode (POLED) based on new electron-transporting host material. The new electron-transporting host material is an adamantane derivative with high triplet energy and high electron mobility. The deep blue POLED that we have developed utilizes a deep-blue phosphorescent guest material, iridium(III)bis(4’,6’,-difluorophenylpyridinato)tetrakis(1-pyrazolyl)borate, and exhibits a power efficiency of about 10.2 lm/W at luminance of 100 cd/m2 and maximum external quantum efficiency (EQE) of about 13 %. The power efficiency of our POLED is much higher than that of POLED using p–bis(triphenylsilyly)benzene (UGH2). The maximum EQE of our POLED was also slightly more than that of POLED using UGH2. The obtained difference in power efficiency originates from the new host material having higher electron mobility than that of UGH2.

In vitro Controlled Release from Solid Pharmaceutical Formulations of two new Adamantane Aminoethers with Antitubercular Activity (I).

Drug Research ◽  
2017 ◽  
Vol 67 (08) ◽  
pp. 447-450 ◽  
Author(s):  
Marilena Vlachou ◽  
Angeliki Siamidi ◽  
Evanthia Diamantidi ◽  
Alexandra Iliopoulou ◽  
Ioannis Papanastasiou ◽  
...  
Keyword(s):  
Controlled Release ◽  
In Vitro Release ◽  
Antitubercular Activity ◽  
Pharmaceutical Formulations ◽  
Adamantane Derivative ◽  
In Vivo Studies ◽  
Matrix Tablet ◽  
The Us

AbstractThe aim of the present investigation was to develop matrix tablet formulations for the in vitro controlled release of 2 new tuberculocidal adamantane aminoethers (compounds I and II), congeneric to the adamantane derivative SQ109, which is in final clinical trials, using carefully selected excipients, such as polyvinylpyrrolidone, sodium alginate and lactose. The tablets were prepared using the direct compression method and dissolution experiments were conducted using the US Pharmacopoeia type II apparatus (paddle method) in gastric and intestinal fluids. The results confirm that both analogues, albeit more lipophilic than SQ109, showed satisfactory in vitro release characteristics from solid pharmaceutical formulations. In conclusion, these formulations merit further assessment by conducting in the future bioavailability in vivo studies.

scholarly journals Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors

2005 ◽  
Vol 145 (5) ◽  
pp. 656-663 ◽  
Author(s):  
Friedrich Schlesinger ◽  
Derk Tammena ◽  
Klaus Krampfl ◽  
Johannes Bufler
Keyword(s):  
Glutamate Receptors ◽  
Mechanisms Of Action ◽  
Adamantane Derivative
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