A chemical proteomic probe for detecting native carrier protein motifs in nonribosomal peptide synthetases

2016 ◽  
Vol 52 (98) ◽  
pp. 14129-14132 ◽  
Author(s):  
Shota Kasai ◽  
Fumihiro Ishikawa ◽  
Takehiro Suzuki ◽  
Naoshi Dohmae ◽  
Hideaki Kakeya
Keyword(s):  
Carrier Protein ◽  
Nonribosomal Peptide ◽  
Nonribosomal Peptide Synthetases ◽  
Protein Motifs ◽  
Peptide Synthetases

An activity-based probe coupled to a 5′-(vinylsulfonylaminodeoxy)adenosine scaffold with a clickable alkyne functionality selectively targets native carrier protein motifs in nonribosomal peptide synthetases.

scholarly journals Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases

2021 ◽  
Author(s):  
Florian Mayerthaler ◽  
Anna-Lena Feldberg ◽  
Jonas Alfermann ◽  
Xun Sun ◽  
Wieland Steinchen ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Protein Domains ◽  
Carrier Protein ◽  
Nonribosomal Peptide ◽  
Nonribosomal Peptide Synthetases ◽  
Peptide Synthetases

In-solution analysis of conformational changes of NRPS adenylation and peptidyl-carrier protein domains under catalytic conditions reveals a new intermediary conformation.

Carrier Protein Recognition in Siderophore-Producing Nonribosomal Peptide Synthetases†

Biochemistry ◽  
2002 ◽  
Vol 41 (26) ◽  
pp. 8429-8437 ◽  
Author(s):  
C. Gary Marshall ◽  
Michael D. Burkart ◽  
Robin K. Meray ◽  
Christopher T. Walsh
Keyword(s):  
Protein Recognition ◽  
Carrier Protein ◽  
Nonribosomal Peptide ◽  
Nonribosomal Peptide Synthetases ◽  
Peptide Synthetases

scholarly journals Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases

2012 ◽  
Vol 109 (15) ◽  
pp. 5681-5686 ◽  
Author(s):  
A. Chhabra ◽  
A. S. Haque ◽  
R. K. Pal ◽  
A. Goyal ◽  
R. Rai ◽  
...  
Keyword(s):  
Nonribosomal Peptide ◽  
Nonribosomal Peptide Synthetases ◽  
Peptide Synthetases
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