scholarly journals Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain

2016 ◽  
Vol 52 (84) ◽  
pp. 12521-12524 ◽  
Author(s):  
Paul T. Bremer ◽  
Song Xue ◽  
Kim D. Janda
Keyword(s):  
Light Chain ◽  
Botulinum Neurotoxin ◽  
Botulinum Neurotoxin A ◽  
Picolinic Acids

A series of novel substituted picolinic acids demonstrated low micromolar inhibition of botulinum neurotoxin A light chain at the β-exosite.

scholarly journals Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library

mAbs ◽  
2014 ◽  
Vol 6 (2) ◽  
pp. 446-459 ◽  
Author(s):  
Sebastian Miethe ◽  
Christine Rasetti-Escargueil ◽  
Yvonne Liu ◽  
Siham Chahboun ◽  
Thibaut Pelat ◽  
...  
Keyword(s):  
Light Chain ◽  
Botulinum Neurotoxin ◽  
Botulinum Neurotoxin A ◽  
Immune Library

scholarly journals Biofunctionalized Gold Nanoparticles for Colorimetric Sensing of Botulinum Neurotoxin A Light Chain

2014 ◽  
Vol 86 (5) ◽  
pp. 2345-2352 ◽  
Author(s):  
Xiaohu Liu ◽  
Yi Wang ◽  
Peng Chen ◽  
Yusong Wang ◽  
Jinling Zhang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Light Chain ◽  
Botulinum Neurotoxin ◽  
Colorimetric Sensing ◽  
Botulinum Neurotoxin A

scholarly journals Time-resolved botulinum neurotoxin A activity monitored using peptide-functionalized Au nanoparticle energy transfer sensors

2014 ◽  
Vol 5 (7) ◽  
pp. 2651-2656 ◽  
Author(s):  
Yi Wang ◽  
Xiaohu Liu ◽  
Jinling Zhang ◽  
Daniel Aili ◽  
Bo Liedberg
Keyword(s):  
Energy Transfer ◽  
Light Chain ◽  
Botulinum Neurotoxin ◽  
Au Nanoparticles ◽  
Au Nanoparticle ◽  
Botulinum Neurotoxin A ◽  
Time Resolved

A peptide mimicking SNAP-25 was immobilized on Au nanoparticles for the monitoring of botulinum neurotoxin light chain A activity.

Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity

2015 ◽  
Vol 51 (28) ◽  
pp. 6226-6229 ◽  
Author(s):  
Hajime Seki ◽  
Song Xue ◽  
Mark S. Hixon ◽  
Sabine Pellett ◽  
Marek Remes̆ ◽  
...  
Keyword(s):  
Light Chain ◽  
Protease Activity ◽  
Botulinum Neurotoxin ◽  
Botulinum Neurotoxin A ◽  
Dual Inhibitors

A polypharmacological approach as a treatment for botulinum neurotoxin A intoxication is presented.

scholarly journals Interactions of a potent cyclic peptide inhibitor with the light chain of botulinum neurotoxin A: Insights from X-ray crystallography

2015 ◽  
Vol 23 (22) ◽  
pp. 7264-7273 ◽  
Author(s):  
Desigan Kumaran ◽  
Michael Adler ◽  
Matthew Levit ◽  
Michael Krebs ◽  
Richard Sweeney ◽  
...  
Keyword(s):  
Light Chain ◽  
Botulinum Neurotoxin ◽  
Cyclic Peptide ◽  
Peptide Inhibitor ◽  
Botulinum Neurotoxin A ◽  
X Ray ◽  
X Ray Crystallography

scholarly journals Identification of Clinically Viable Quinolinol Inhibitors of Botulinum Neurotoxin A Light Chain

2014 ◽  
Vol 57 (3) ◽  
pp. 669-676 ◽  
Author(s):  
Dejan Caglič ◽  
Michelle C. Krutein ◽  
Kristin M. Bompiani ◽  
Deborah J. Barlow ◽  
Galit Benoni ◽  
...  
Keyword(s):  
Light Chain ◽  
Botulinum Neurotoxin ◽  
Botulinum Neurotoxin A
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