Chiral and fractal: from simple design rules to complex supramolecular constructs

2016 ◽  
Vol 52 (78) ◽  
pp. 11642-11645 ◽  
Author(s):  
D. Nieckarz ◽  
P. Szabelski
Keyword(s):  
Self Assembly ◽  
Theoretical Modeling ◽  
Simple Design ◽  
Fractal Aggregates ◽  
Design Rules

The surface-confined self-assembly of K- and A-shaped molecular bricks with carefully adjusted size and functionality into fractal aggregates is demonstrated using theoretical modeling.

Aromatic identity, electronic substitution, and sequence in amphiphilic tripeptide self-assembly

Soft Matter ◽  
2018 ◽  
Vol 14 (45) ◽  
pp. 9168-9174 ◽  
Author(s):  
Jugal Kishore Sahoo ◽  
Calvin Nazareth ◽  
Michael A. VandenBerg ◽  
Matthew J. Webber
Keyword(s):  
Self Assembly ◽  
Short Peptides ◽  
Design Rules ◽  
Sequence Variations

The design rules for self-assembly of short peptides are assessed using a combination of chemical and sequence variations.

Peptide α-helices for synthetic nanostructures

2007 ◽  
Vol 35 (3) ◽  
pp. 487-491 ◽  
Author(s):  
M.G. Ryadnov
Keyword(s):  
Self Assembly ◽  
De Novo ◽  
Three Dimensional ◽  
Functional Materials ◽  
Protein Assemblies ◽  
Helical Peptides ◽  
Design Rules ◽  
Natural Protein ◽  
Self Assembling ◽  
Recent Developments

Supramolecular structures arising from a broad range of chemical archetypes are of great technological promise. Defining such structures at the nanoscale is crucial to access principally new types of functional materials for applications in bionanotechnology. In this vein, biomolecular self-assembly has emerged as an efficient approach for building synthetic nanostructures from the bottom up. The approach predominantly employs the spontaneous folding of biopolymers to monodisperse three-dimensional shapes that assemble into hierarchically defined mesoscale composites. An immediate interest here is the extraction of reliable rules that link the chemistry of biopolymers to the mechanisms of their assembly. Once established these can be further harnessed in designing supramolecular objects de novo. Different biopolymer classes compile a rich repertoire of assembly motifs to facilitate the synthesis of otherwise inaccessible nanostructures. Among those are peptide α-helices, ubiquitous folding elements of natural protein assemblies. These are particularly appealing candidates for prescriptive supramolecular engineering, as their well-established and conservative design rules give unmatched predictability and rationale. Recent developments of self-assembling systems based on helical peptides, including fibrous systems, nanoscale linkers and reactors will be highlighted herein.

scholarly journals Electrocharged facepiece respirator fabrics using common materials

2020 ◽  
Vol 476 (2243) ◽  
pp. 20200469
Author(s):  
M. M. Bandi
Keyword(s):  
Design Principles ◽  
Simple Design ◽  
Design Rules ◽  
Global Pandemic ◽  
Practical Design ◽  
Cotton Candy ◽  
Set Up ◽  
Filtration Properties ◽  
Plastic Containers

Face masks in general, and N95 filtering facepiece respirators (FRs) that protect against SARS-Cov-2 virion in particular, have become scarce during the ongoing COVID-19 global pandemic. This work presents practical design principles for the fabrication of electrocharged filtration layers employed in N95 FRs using commonly available materials and easily replicable methods. The input polymer is polypropylene or polystyrene, and can include discarded plastic containers of these materials, and the fabrication set-up is based on the cotton candy (CC) principle. The primary parameters underlying the CC principle are translated to simple design rules that allow anyone to construct their own fabrication system from common parts, or employ a commercial CC machine with minimal modifications. Finally, basic characterization results for structural and filtration properties of electrocharged fabrics made using the CC principle are detailed.

scholarly journals Biocatalysis of d,l-Peptide Nanofibrillar Hydrogel

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 2995 ◽  
Author(s):  
Tiziano Carlomagno ◽  
Maria C. Cringoli ◽  
Slavko Kralj ◽  
Marina Kurbasic ◽  
Paolo Fornasiero ◽  
...  
Keyword(s):  
Self Assembly ◽  
Solid Phase ◽  
Building Blocks ◽  
Cd Spectroscopy ◽  
Tem Analysis ◽  
Design Rules ◽  
Self Assembling ◽  
Transmission Electron ◽  
Oscillatory Rheometry ◽  
The Many

Self-assembling peptides are attracting wide interest as biodegradable building blocks to achieve functional nanomaterials that do not persist in the environment. Amongst the many applications, biocatalysis is gaining momentum, although a clear structure-to-activity relationship is still lacking. This work applied emerging design rules to the heterochiral octapeptide sequence His–Leu–DLeu–Ile–His–Leu–DLeu–Ile for self-assembly into nanofibrils that, at higher concentration, give rise to a supramolecular hydrogel for the mimicry of esterase-like activity. The peptide was synthesized by solid-phase and purified by HPLC, while its identity was confirmed by 1H-NMR and electrospray ionization (ESI)-MS. The hydrogel formed by this peptide was studied with oscillatory rheometry, and the supramolecular behavior of the peptide was investigated with transmission electron microscopy (TEM) analysis, circular dichroism (CD) spectroscopy, thioflavin T amyloid fluorescence assay, and attenuated total reflectance (ATR) Fourier-transform infrared (FT-IR) spectroscopy. The biocatalytic activity was studied by monitoring the hydrolysis of p-nitrophenyl acetate (pNPA) at neutral pH, and the reaction kinetics followed an apparent Michaelis–Menten model, for which a Lineweaver–Burk plot was produced to determine its enzymatic parameters for a comparison with the literature. Finally, LC–MS analysis was conducted on a series of experiments to evaluate the extent of, if any, undesired peptide acetylation at the N-terminus. In conclusion, we provide new insights that allow gaining a clearer picture of self-assembling peptide design rules for biocatalysis.

scholarly journals A method for nanofluidic device prototyping using elastomeric collapse

2009 ◽  
Vol 106 (37) ◽  
pp. 15549-15554 ◽  
Author(s):  
Seung-min Park ◽  
Yun Suk Huh ◽  
Harold G. Craighead ◽  
David Erickson
Keyword(s):  
Applied Strain ◽  
Simple Design ◽  
Pdms Mold ◽  
Design Rules ◽  
Surface Enhanced ◽  
Elastomeric Materials ◽  
Surface Enhanced Raman ◽  
Promising Solution ◽  
Nanofluidic Device ◽  
Biomolecular Analysis

Nanofluidics represents a promising solution to problems in fields ranging from biomolecular analysis to optical property tuning. Recently a number of simple nanofluidic fabrication techniques have been introduced that exploit the deformability of elastomeric materials like polydimethylsiloxane (PDMS). These techniques are limited by the complexity of the devices that can be fabricated, which can only create straight or irregular channels normal to the direction of an applied strain. Here, we report a technique for nanofluidic fabrication based on the controlled collapse of microchannel structures. As is demonstrated, this method converts the easy to control vertical dimension of a PDMS mold to the lateral dimension of a nanochannel. We demonstrate here the creation of complex nanochannel structures as small as 60 nm and provide simple design rules for determining the conditions under which nanochannel formation will occur. The applicability of the technique to biomolecular analysis is demonstrated by showing DNA elongation in a nanochannel and a technique for optofluidic surface enhanced Raman detection of nucleic acids.

Fluctuating Lift Forces on Aerofoils Moving Through Transverse and Chordwise Gusts

1968 ◽  
Vol 90 (4) ◽  
pp. 494-500 ◽  
Author(s):  
J. H. Horlock
Keyword(s):  
Compressor Blade ◽  
Simple Design ◽  
Flow Disturbance ◽  
Design Rules ◽  
Lift Forces ◽  
Undisturbed Flow

An analysis is given for determining the lift fluctuation on an aerofoil due to a gust parallel to the undisturbed flow. By combining the new analysis with an established theory for “transverse” gusts perpendicular to the undisturbed flow, it is possible to obtain the fluctuating lift on a rotating fan or compressor blade moving through a flow disturbance. It is shown that simple design rules may be derived for fans and compressors if the fluctuating lift forces, and possibly therefore the associated noise, are to be reduced.

AN ADAPTIVE OBSERVER DESIGN FOR AUTO-SYNCHRONIZATION OF LORENZ SYSTEM

2008 ◽  
Vol 18 (08) ◽  
pp. 2415-2423 ◽  
Author(s):  
YING LIU ◽  
WALLACE TANG ◽  
LJUPCO KOCAREV
Keyword(s):  
Lyapunov Exponents ◽  
Chaotic Systems ◽  
Lorenz System ◽  
Observer Design ◽  
Adaptive Observer ◽  
Simple Design ◽  
Unknown Parameters ◽  
Dynamical Equations ◽  
Design Rules ◽  
The Past

Synchronization of chaotic systems with unknown parameters, or namely auto-synchronization, has aroused a lot of interest in the past few years. In this paper, we are interested in solving one of the critical cases in Lorenz system. Based on the past researches, it was concluded that the auto-synchronization of Lorenz system was inachievable if the unknown parameters resided in all of its three dynamical equations while only the first state was measurable. However, as demonstrated in this paper, this problem can be resolved by an adaptive observer following simple design rules. The design is justified with the conditional Lyapunov exponents, and its effectiveness is clearly illustrated in simulations.

Sign in / Sign up

Export Citation Format

Share Document