Design Rules: A Net and Archimedean Polyhedra Score Big for Self-Assembly

2012 ◽  
Vol 51 (5) ◽  
pp. 1110-1112 ◽  
Author(s):  
Leonard R. MacGillivray
Keyword(s):  
Self Assembly ◽  
Design Rules

Aromatic identity, electronic substitution, and sequence in amphiphilic tripeptide self-assembly

Soft Matter ◽  
2018 ◽  
Vol 14 (45) ◽  
pp. 9168-9174 ◽  
Author(s):  
Jugal Kishore Sahoo ◽  
Calvin Nazareth ◽  
Michael A. VandenBerg ◽  
Matthew J. Webber
Keyword(s):  
Self Assembly ◽  
Short Peptides ◽  
Design Rules ◽  
Sequence Variations

The design rules for self-assembly of short peptides are assessed using a combination of chemical and sequence variations.

Peptide α-helices for synthetic nanostructures

2007 ◽  
Vol 35 (3) ◽  
pp. 487-491 ◽  
Author(s):  
M.G. Ryadnov
Keyword(s):  
Self Assembly ◽  
De Novo ◽  
Three Dimensional ◽  
Functional Materials ◽  
Protein Assemblies ◽  
Helical Peptides ◽  
Design Rules ◽  
Natural Protein ◽  
Self Assembling ◽  
Recent Developments

Supramolecular structures arising from a broad range of chemical archetypes are of great technological promise. Defining such structures at the nanoscale is crucial to access principally new types of functional materials for applications in bionanotechnology. In this vein, biomolecular self-assembly has emerged as an efficient approach for building synthetic nanostructures from the bottom up. The approach predominantly employs the spontaneous folding of biopolymers to monodisperse three-dimensional shapes that assemble into hierarchically defined mesoscale composites. An immediate interest here is the extraction of reliable rules that link the chemistry of biopolymers to the mechanisms of their assembly. Once established these can be further harnessed in designing supramolecular objects de novo. Different biopolymer classes compile a rich repertoire of assembly motifs to facilitate the synthesis of otherwise inaccessible nanostructures. Among those are peptide α-helices, ubiquitous folding elements of natural protein assemblies. These are particularly appealing candidates for prescriptive supramolecular engineering, as their well-established and conservative design rules give unmatched predictability and rationale. Recent developments of self-assembling systems based on helical peptides, including fibrous systems, nanoscale linkers and reactors will be highlighted herein.

scholarly journals Biocatalysis of d,l-Peptide Nanofibrillar Hydrogel

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 2995 ◽  
Author(s):  
Tiziano Carlomagno ◽  
Maria C. Cringoli ◽  
Slavko Kralj ◽  
Marina Kurbasic ◽  
Paolo Fornasiero ◽  
...  
Keyword(s):  
Self Assembly ◽  
Solid Phase ◽  
Building Blocks ◽  
Cd Spectroscopy ◽  
Tem Analysis ◽  
Design Rules ◽  
Self Assembling ◽  
Transmission Electron ◽  
Oscillatory Rheometry ◽  
The Many

Self-assembling peptides are attracting wide interest as biodegradable building blocks to achieve functional nanomaterials that do not persist in the environment. Amongst the many applications, biocatalysis is gaining momentum, although a clear structure-to-activity relationship is still lacking. This work applied emerging design rules to the heterochiral octapeptide sequence His–Leu–DLeu–Ile–His–Leu–DLeu–Ile for self-assembly into nanofibrils that, at higher concentration, give rise to a supramolecular hydrogel for the mimicry of esterase-like activity. The peptide was synthesized by solid-phase and purified by HPLC, while its identity was confirmed by 1H-NMR and electrospray ionization (ESI)-MS. The hydrogel formed by this peptide was studied with oscillatory rheometry, and the supramolecular behavior of the peptide was investigated with transmission electron microscopy (TEM) analysis, circular dichroism (CD) spectroscopy, thioflavin T amyloid fluorescence assay, and attenuated total reflectance (ATR) Fourier-transform infrared (FT-IR) spectroscopy. The biocatalytic activity was studied by monitoring the hydrolysis of p-nitrophenyl acetate (pNPA) at neutral pH, and the reaction kinetics followed an apparent Michaelis–Menten model, for which a Lineweaver–Burk plot was produced to determine its enzymatic parameters for a comparison with the literature. Finally, LC–MS analysis was conducted on a series of experiments to evaluate the extent of, if any, undesired peptide acetylation at the N-terminus. In conclusion, we provide new insights that allow gaining a clearer picture of self-assembling peptide design rules for biocatalysis.

Design of surface patterns with optimized thermodynamic driving forces for the directed self-assembly of block copolymers in lithographic applications

2017 ◽  
Vol 2 (5) ◽  
pp. 567-580 ◽  
Author(s):  
Grant P. Garner ◽  
Paulina Rincon Delgadillo ◽  
Roel Gronheid ◽  
Paul F. Nealey ◽  
Juan J. de Pablo
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Driving Forces ◽  
Theoretical Method ◽  
Design Rules ◽  
Surface Patterns

A theoretical method for developing design rules for the directed self-assembly of block copolymers for lithographic applications.

scholarly journals Design Rules for Self‐Assembly of 2D Nanocrystal/Metal–Organic Framework Superstructures

2018 ◽  
Vol 130 (40) ◽  
pp. 13356-13360
Author(s):  
Fen Qiu ◽  
John R. Edison ◽  
Zdenek Preisler ◽  
Yan‐Fang Zhang ◽  
Guo Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Metal Organic Framework ◽  
Design Rules ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Design Rules for Self‐Assembly of 2D Nanocrystal/Metal–Organic Framework Superstructures

2018 ◽  
Vol 57 (40) ◽  
pp. 13172-13176 ◽  
Author(s):  
Fen Qiu ◽  
John R. Edison ◽  
Zdenek Preisler ◽  
Yan‐Fang Zhang ◽  
Guo Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Metal Organic Framework ◽  
Design Rules ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Design rules for the self-assembly of a protein crystal

Soft Matter ◽  
2012 ◽  
Vol 8 (13) ◽  
pp. 3558 ◽  
Author(s):  
Thomas K. Haxton ◽  
Stephen Whitelam
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Protein Crystal ◽  
Design Rules

Chiral and fractal: from simple design rules to complex supramolecular constructs

2016 ◽  
Vol 52 (78) ◽  
pp. 11642-11645 ◽  
Author(s):  
D. Nieckarz ◽  
P. Szabelski
Keyword(s):  
Self Assembly ◽  
Theoretical Modeling ◽  
Simple Design ◽  
Fractal Aggregates ◽  
Design Rules

The surface-confined self-assembly of K- and A-shaped molecular bricks with carefully adjusted size and functionality into fractal aggregates is demonstrated using theoretical modeling.

Tuning PNIPAm self-assembly and thermoresponse: roles of hydrophobic end-groups and hydrophilic comonomer

2019 ◽  
Vol 10 (25) ◽  
pp. 3469-3479 ◽  
Author(s):  
Monica L. Ohnsorg ◽  
Jeffrey M. Ting ◽  
Seamus D. Jones ◽  
Seyoung Jung ◽  
Frank S. Bates ◽  
...  
Keyword(s):  
Cloud Point ◽  
Systematic Study ◽  
Self Assembly ◽  
Design Rules ◽  
End Groups

Systematic study of hydrophobic and hydrophilic modifications to poly(N-isopropylacrylamide) elucidates design rules for control over cloud point and aqueous self-assembly.

Sign in / Sign up

Export Citation Format

Share Document