Plasmonic coupling of dual gold nanoprobes for SERS imaging of sialic acids on living cells

2016 ◽  
Vol 52 (70) ◽  
pp. 10640-10643 ◽  
Author(s):  
Wanyao Song ◽  
Lin Ding ◽  
Yunlong Chen ◽  
Huangxian Ju
Keyword(s):  
Au Nanoparticles ◽  
Living Cells ◽  
Sialic Acids ◽  
Plasmonic Coupling ◽  
Sers Signal ◽  
Sers Imaging

A single-core–multi-satellite nanostructure was designed by the recognition of target sialic acids and the assembly of functional Au nanoparticles into a Au nanoflower-based probe, which leads to plasmonic coupling of two kinds of Au nanoprobes to produce a sensitive SERS signal for the imaging of sialic acids on living cells.

Probing Hydroxyl Radicals and Their Imaging in Living Cells by Use of FAM–DNA–Au Nanoparticles

2008 ◽  
Vol 14 (2) ◽  
pp. 522-528 ◽  
Author(s):  
Bo Tang ◽  
Ning Zhang ◽  
Zhenzhen Chen ◽  
Kehua Xu ◽  
Linhai Zhuo ◽  
...  
Keyword(s):  
Hydroxyl Radicals ◽  
Au Nanoparticles ◽  
Living Cells

Assembled growth of 3D Fe3O4@Au nanoparticles for efficient photothermal ablation and SERS detection of microorganisms

2018 ◽  
Vol 6 (36) ◽  
pp. 5689-5697 ◽  
Author(s):  
Wei-En Hong ◽  
I-Ling Hsu ◽  
Szu-Yung Huang ◽  
Chien-Wei Lee ◽  
Han Ko ◽  
...  
Keyword(s):  
Antibacterial Agent ◽  
Au Nanoparticles ◽  
Sers Signal ◽  
Photothermal Ablation ◽  
Sers Detection

A leukocyte-like Fe3O4@Au-polydopamine nanohybrid performed a magnetism-based enhanced SERS signal and efficient NIR-irradiated photothermal antibacterial agent.

scholarly journals Temperature monitoring during light-induced release of cargo using polymer capsules modified with gold nanoparticles and nanodiamonds

2021 ◽  
Vol 2015 (1) ◽  
pp. 012045
Author(s):  
E N Gerasimova ◽  
V V Yaroshenko ◽  
P M Talianov ◽  
O O Peltek ◽  
L V Mikhailova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Side Effects ◽  
Temperature Measurement ◽  
Real Time ◽  
Au Nanoparticles ◽  
Living Cells ◽  
Temperature Monitoring ◽  
Biological Objects ◽  
Multifunctional Platform

Abstract Application of different light-sensitive drug delivery carriers is limited due to a risk of overheating of living cells. Therefore, a real-time temperature monitoring within biological objects that controls the photothermal release of different cargos from light-sensitive carriers is highly demanded. In this work, we develop a multifunctional platform comprised of polymer microcapsules modified with nitrogen vacancies (NV) centers as nanothermometers and gold (Au) nanoparticles (NPs) as heating elements for the realization of laser-induced cargo release with a simultaneous temperature measurement inside cells. Such platform allows to prevent unwanted side effects related with the overheating of living cells and tissues.

scholarly journals Multimodal Gold Nanostars as SERS Tags for Optically-Driven Doxorubicin Release Study in Cancer Cells

Materials ◽  
2021 ◽  
Vol 14 (23) ◽  
pp. 7272
Author(s):  
Luca Minati ◽  
Devid Maniglio ◽  
Filippo Benetti ◽  
Andrea Chiappini ◽  
Giorgio Speranza
Keyword(s):  
Laser Scanning ◽  
Close Contact ◽  
Gold Surface ◽  
Laser Scanning Confocal Microscopy ◽  
Living Cells ◽  
Sers Signal ◽  
Scanning Confocal Microscopy ◽  
Gold Nanostars ◽  
Real Time Analysis

Surface Enhanced Raman Scattering (SERS) active gold nanostars represent an opportunity in the field of bioimaging and drug delivery. The combination of gold surface chemical versatility with the possibility to tune the optical properties changing the nanoparticles shape constitutes a multimodal approach for the investigation of the behavior of these carriers inside living cells. In this work, SERS active star-shaped nanoparticles were functionalized with doxorubicin molecules and covered with immuno-mimetic thiolated polyethylene glycol (PEG). Doxorubicin-conjugate gold nanoparticles show an intense Raman enhancement, a good stability in physiological conditions, and a low cytotoxicity. The strong adsorption of the anticancer drug doxorubicin in close contact with the gold nanostars surface enables their use as SERS tag imaging probes in vivo. Upon laser irradiation of the nanoparticles, a strong SERS signal is generated by the doxorubicin molecules close to the nanostars surface, enabling the localization of the nanoparticles inside the cells. After long time irradiation, the SERS signal drops, indicating the thermally driven delivery of the drug inside the cell. Therefore, the combination of SERS and laser scanning confocal microscopy is a powerful technique for the real-time analysis of drug release in living cells.

Porous Hollow Gold Nanoparticles for Cancer SERS Imaging

2010 ◽  
Vol 10 ◽  
pp. 137-148 ◽  
Author(s):  
Chien Wen Huang ◽  
Yao Wu Hao ◽  
James Nyagilo ◽  
Digant P. Dave ◽  
Li Feng Xu ◽  
...  
Keyword(s):  
Large Scale ◽  
Near Infrared ◽  
Au Nanoparticles ◽  
Imaging Modality ◽  
Surface Enhanced Raman Spectroscopy ◽  
Au Nanoparticle ◽  
Resonant Effect ◽  
Surface Enhanced Raman ◽  
Sers Imaging

Surface enhanced Raman spectroscopy (SERS) is a promising molecular imaging modality capable of simultaneously detecting multiple molecular biomarkers. With the biocompatibility and functionalizability of Au, Au-nanoparticle based Raman tags possess the potential for in vivo SERS cancer biomarker detection. Here, we report the large scale synthesis of a new type of Au nanoparticles, Porous Hollow Au Nanoparticles (PHAuNPs), and demonstrate their potential application as SERS imaging tags. PHAuNPs feature a sub-20 nm porous shell and a 50 nm void core. Such unique morphology enables them to strongly absorb and scatter near infrared lights due to the surface plasmon resonant effect of Au. This makes them particularly suitable for in vivo applications, where NIR wavelengths are considered as a ‘clear window’ for deeper penetration of light. The construction and characterization of PHAuNP-based Raman nanotag, including attachment of Raman dye, pegylation and their stability, are described. Cytotoxicity of Raman nanotags are tested using the radioactive [3H]thymidine incorporation method. The results show that pegylated Raman nanotags are stable and non-toxic and can potentially be used for in vivo applications.

Quantum Dots with Phenylboronic Acid Tags for Specific Labeling of Sialic Acids on Living Cells

2011 ◽  
Vol 83 (3) ◽  
pp. 1124-1130 ◽  
Author(s):  
Aiping Liu ◽  
Shuo Peng ◽  
Jian Chow Soo ◽  
Min Kuang ◽  
Peng Chen ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Phenylboronic Acid ◽  
Living Cells ◽  
Sialic Acids

Synthesis of size-tunable chitosan encapsulated gold–silver nanoflowers and their application in SERS imaging of living cells

2015 ◽  
Vol 17 (33) ◽  
pp. 21261-21267 ◽  
Author(s):  
Guannan Zhang ◽  
Junrong Li ◽  
Aiguo Shen ◽  
Jiming Hu
Keyword(s):  
Cancer Cell ◽  
Living Cells ◽  
Cell Targeting ◽  
One Pot ◽  
One Pot Synthesis ◽  
Gold Silver ◽  
Sers Imaging ◽  
Cancer Cell Targeting ◽  
Sers Tags

Monodispersed and biocompatible SERS tags are conveniently developed by one-pot synthesis and applied for cancer cell targeting and SERS imaging.

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