scholarly journals Cavity-containing supramolecular gels as a crystallization tool for hydrophobic pharmaceuticals

2016 ◽  
Vol 52 (66) ◽  
pp. 10113-10116 ◽  
Author(s):  
Lena Kaufmann ◽  
Stuart R. Kennedy ◽  
Christopher D. Jones ◽  
Jonathan W. Steed
Keyword(s):  
Molecular Weight ◽  
Building Blocks ◽  
Low Molecular Weight ◽  
Supramolecular Gels

We present two approaches to low-molecular-weight supramolecular gels bearing hydrophobic cavities based on calixarene-containing building blocks.

scholarly journals Development of Natural-Drugs-Based Low-Molecular-Weight Supramolecular Gels

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 105
Author(s):  
Xiaoyi Feng ◽  
Yuning Luo ◽  
Fangjie Li ◽  
Xueting Jian ◽  
Yang Liu
Keyword(s):  
Molecular Weight ◽  
Self Assembly ◽  
Water Solubility ◽  
Drug Loading ◽  
Building Blocks ◽  
Low Molecular Weight ◽  
Assembly Mechanism ◽  
Supramolecular Gels ◽  
Potential Applications ◽  
Natural Drugs

Natural small molecular drugs with excellent biocompatibility, diverse pharmacological activities, and wide sources play an increasingly important role in the development of new drug and disease treatment. In recent years, the utilization of paclitaxel, camptothecin, rhein, curcumin, and other natural small molecular drugs with unique rigid backbone structures and modifiable multiple sites as building blocks to form gels by self-assembly has attracted widespread attention. The obtained low-molecular-weight supramolecular gel not only retains the general characteristics of the gel but also overcomes the shortcomings of natural drugs, such as poor water solubility and low bioavailability. It has the advantages of high drug loading, low toxicity, and outstanding stimulus responsiveness, which is widely used in biomedical fields. Here, we provided a comprehensive review of natural-drugs-based low-molecular-weight supramolecular gels reported in recent years and summarized their assembly mechanism, gel structure, gel properties, and potential applications. It is expected to provide a reference for further research of natural-drugs-based supramolecular gels.

scholarly journals Facile construction of a family of supramolecular gels with good levofloxacin hydrochloride loading capacity

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12641-12648
Author(s):  
Renyuan Chen ◽  
Caidie Xu ◽  
Yihao Lei ◽  
Hongxin Liu ◽  
Yabin Zhu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Alkyl Chain ◽  
Low Molecular Weight ◽  
Loading Capacity ◽  
Supramolecular Gels ◽  
Low Molecular Weight Gelators ◽  
Chain Lengths

A family of low molecular weight gelators with different alkyl chain lengths was constructed, having excellent gelation ability and antibiotic loading capacity. A low molecular weight hydrogelator was obtained by adjusting the length of alkyl chain.

Diaminomalenonitrile-decorated cholesterol-based supramolecular gelator: aggregation, multiple analyte (hydrazine, Hg2+ and Cu2+) detection and dye adsorption

2018 ◽  
Vol 42 (16) ◽  
pp. 13718-13725 ◽  
Author(s):  
Atanu Panja ◽  
Kumaresh Ghosh
Keyword(s):  
Molecular Weight ◽  
Functional Group ◽  
Dye Adsorption ◽  
Low Molecular Weight ◽  
Practical Applications ◽  
Supramolecular Gels ◽  
Low Molecular Weight Gelator

A low molecular weight gelator (LMWG) containing a diaminomalenonitrile functional group 1 forms supramolecular gels from DMF–H2O and 1,2-dichlorobenzene. The DMF/H2O gel is multi-analyte responsive (Hg2+, Cu2+ and hydrazine) with practical applications in dye adsorption from water.

scholarly journals Supramolecular gels derived from nucleoside based bolaamphiphiles as a light-sensitive soft material

2020 ◽  
Vol 56 (23) ◽  
pp. 3397-3400 ◽  
Author(s):  
Julie Baillet ◽  
Alexandra Gaubert ◽  
Dario M. Bassani ◽  
Julien Verget ◽  
Laurent Latxague ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Soft Material ◽  
Low Molecular Weight ◽  
Supramolecular Gels ◽  
Low Molecular Weight Gelators

Light-sensitive Low Molecular Weight Gelators (LMWGs) derived from glyconucleoside bolaamphiphiles containing a stilbene unit displayed gelation abilities in hydroalcoholic mixtures.

scholarly journals Biologically active ion exchange (BIEX) for NOM removal and membrane fouling prevention

2017 ◽  
Vol 17 (4) ◽  
pp. 1178-1184 ◽  
Author(s):  
M. Schulz ◽  
J. Winter ◽  
H. Wray ◽  
B. Barbeau ◽  
P. Bérubé
Keyword(s):  
Molecular Weight ◽  
Biological Activity ◽  
Ion Exchange ◽  
Membrane Fouling ◽  
Building Blocks ◽  
Biologically Active ◽  
Low Molecular Weight ◽  
Effective Removal ◽  
Pre Treatment ◽  
The Impact

The natural organic matter (NOM) removal efficiency and regeneration behavior of ion-exchange filters with promoted biological activity (BIEX) was compared to operation where biological activity was suppressed (i.e. abiotic conditions). The impact of BIEX pre-treatment on fouling in subsequent ultrafiltration was also investigated. Biological operation enhanced NOM removal by approximately 50% due to an additional degradation of smaller humic substances, building blocks and low molecular weight acids. Promotion of biological activity significantly increased the time to breakthrough of the filters and, therefore, is expected to lower the regeneration frequency as well as the amount of regenerate of which to dispose. Pre-treatment using BIEX filters resulted in a significant decrease in total and irreversible fouling during subsequent ultrafiltration. The decrease was attributed to the effective removal of medium and low molecular weight NOM fractions. The results indicate that BIEX filtration is a robust, affordable and easy-to-operate pre-treatment approach to minimize fouling in ultrafiltration systems and enhance the quality of the produced permeate.

scholarly journals Iron Catalyzed Synthesis and Chemical Recycling of Telechelic, 1,3-Enchained Oligocyclobutanes

2020 ◽  
Author(s):  
Megan Mohadjer Beromi ◽  
C. Rose Kennedy ◽  
Jarod M. Younker ◽  
Alex E. Carpenter ◽  
Sarah J. Mattler ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Closed Loop ◽  
Building Blocks ◽  
Plastic Waste ◽  
Low Molecular Weight ◽  
Chemical Recycling ◽  
Thermally Stable ◽  
Hydrocarbon Feedstock ◽  
High Crystallinity

Closed-loop recycling offers the opportunity to help mitigate plastic waste through reversible polymer construction and deconstruction. While examples of the chemical recycling polymers are known, few have been applied to materials derived from abundant commodity olefinic monomers that are the building blocks of ubiquitous plastic resins. Here we describe a [2+2] cycloaddition oligomerization of 1,3-butadiene to yield a previously unrealized telechelic microstructure of (1,n’-divinyl)oligocyclobutane. This material is thermally stable, has stereoregular segments arising from chain-end control, and exhibits high crystallinity even at low molecular weight. Exposure of the oligocyclobutane to vacuum in the presence of the pyridine(diimine) iron precatalyst used to synthesize it resulted in deoligomerization to generate pristine butadiene, demonstrating a rare example of closed-loop chemical recycling of an oligomeric material derived from a commodity hydrocarbon feedstock.

Efficient synthesis of the nonamannoside residue of high mannose glycoproteins

2005 ◽  
Vol 83 (6-7) ◽  
pp. 693-701 ◽  
Author(s):  
Lu Jiang ◽  
Tak Hang Chan
Keyword(s):  
Molecular Weight ◽  
Polyethylene Glycol ◽  
Key Words ◽  
Building Blocks ◽  
Polymer Support ◽  
Low Molecular Weight ◽  
Oligosaccharide Synthesis ◽  
Efficient Synthesis ◽  
Solution Synthesis ◽  
High Mannose

An efficient synthesis of the nonamannoside residue 1 of high mannose glycoproteins was achieved using an oligomer-supported solution synthesis with low-molecular-weight polyethylene glycol as the anchor. The synthesis required only five coupling steps from only two monosaccharide building blocks with an overall yield of 12%.Key words: nonamannoside, oligosaccharide synthesis, soluble polymer support synthesis, glycoproteins.

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