Efficient synthesis of the nonamannoside residue of high mannose glycoproteins

2005 ◽  
Vol 83 (6-7) ◽  
pp. 693-701 ◽  
Author(s):  
Lu Jiang ◽  
Tak Hang Chan
Keyword(s):  
Molecular Weight ◽  
Polyethylene Glycol ◽  
Key Words ◽  
Building Blocks ◽  
Polymer Support ◽  
Low Molecular Weight ◽  
Oligosaccharide Synthesis ◽  
Efficient Synthesis ◽  
Solution Synthesis ◽  
High Mannose

An efficient synthesis of the nonamannoside residue 1 of high mannose glycoproteins was achieved using an oligomer-supported solution synthesis with low-molecular-weight polyethylene glycol as the anchor. The synthesis required only five coupling steps from only two monosaccharide building blocks with an overall yield of 12%.Key words: nonamannoside, oligosaccharide synthesis, soluble polymer support synthesis, glycoproteins.

Effects of ultrasonic cavitation on neutralization process of low molecular weight polyethylene glycol

2018 ◽  
Vol 97 (1) ◽  
pp. 395-405 ◽  
Author(s):  
Abbas Azarpour ◽  
Sohrab Zendehboudi ◽  
Suzana Yusup ◽  
Athirah Khalid ◽  
Yahui Zhang
Keyword(s):  
Molecular Weight ◽  
Polyethylene Glycol ◽  
Ultrasonic Cavitation ◽  
Low Molecular Weight ◽  
Neutralization Process

scholarly journals An Improved Procedure for the Preparation of Thrombin Low Molecular Weight Substrates - Peptide p-Nitroanilides

2018 ◽  
Vol 1 (4) ◽  
pp. e00057 ◽  
Author(s):  
A.A Chistov ◽  
A.V. Talanova ◽  
M.V. Melnikova ◽  
S.S. Kuznetsova ◽  
E.F. Kolesanova
Keyword(s):  
Molecular Weight ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Potassium Sulfate ◽  
Polymer Support ◽  
Low Molecular Weight ◽  
Chromogenic Substrate ◽  
Peptide Substrates ◽  
Terminal Amino ◽  
Hydrolysis Of

Low molecular weight chromogenic thrombin peptide substrates, p-nitroanilides of short peptides protected at their N-terminal amino group, were prepared by solid-phase peptide synthesis on polystyrene-divinylbenzene polymer with trityl groups with preliminary attached p-phenylene diamine moiety. After the cleavage from the resin peptide p-aminoanilides were mildly oxidized to p-nitroanilides with the mixture of potassium sulfate and persulfate. Adsorption onto polymer support Bio-Beads SM-2 with further elution by acetonitrile allowed easy separating peptide p-nitroanilides from the oxidizer and obtaining the thrombin chromogenic substrate preparations with the target substance contents of not less than 95% and yields of 30-40%. Thrombin effectively catalyzed hydrolysis of the prepared substrates with KM and Vmax values of 29-134 mM and 0.03-1/16 mM/s, respectively.

scholarly journals Research and Application of Polycarboxylic Acid Water Reducer with Different Molecular Weight

2020 ◽  
Vol 179 ◽  
pp. 01021
Author(s):  
Bobo Liu ◽  
Kangjian Yu ◽  
Yinggang Yang ◽  
Donghui Miao ◽  
Chong He
Keyword(s):  
Molecular Weight ◽  
Polyethylene Glycol ◽  
Reducing Agent ◽  
Acid Water ◽  
Low Molecular Weight ◽  
High Grade ◽  
Polycarboxylic Acid ◽  
Different Molecular Weight

In this paper, a polycarboxylic water reducing agent was synthesized by using Methylallyl polyethylene glycol (HPEG) with molecular weight of 1200, 2400, 2800 and 3400 under the same conditions, C80 concrete tests were performed on these four molecular weight superplasticizers, verify the effect of different molecular weight polycarboxylic acid water reducer in C80 pumping concrete, finally, a kind of low molecular weight polycarboxylic acid water reducer with viscosity reducing effect in high-grade concrete is obtained, which can promote pumping of high-grade concrete.

Improved CO2separation performance of Matrimid®5218 membrane by addition of low molecular weight polyethylene glycol

2015 ◽  
Vol 5 (5) ◽  
pp. 530-544 ◽  
Author(s):  
Mahsa Loloei ◽  
Abdolreza Moghadassi ◽  
Mohammadreza Omidkhah ◽  
Abtin Ebadi Amooghin
Keyword(s):  
Molecular Weight ◽  
Polyethylene Glycol ◽  
Low Molecular Weight

Synthesis of a hexasaccharide fragment of the capsular polysaccharide of Streptococcus pneumoniae type 3

2002 ◽  
Vol 80 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Dirk J Lefeber ◽  
Eneko Aldaba Arévalo ◽  
Johannis P Kamerling ◽  
Johannes FG Vliegenthart
Keyword(s):  
Streptococcus Pneumoniae ◽  
Key Words ◽  
Selective Oxidation ◽  
Capsular Polysaccharide ◽  
Building Blocks ◽  
Oligosaccharide Synthesis ◽  
Tempo Oxidation ◽  
Carboxylic Groups ◽  
New Generation ◽  
Type 3

In the framework of the development of a new generation of neoglycoconjugate vaccines against Streptococcus pneumoniae, the synthesis is described of a spacer-containing hexasaccharide fragment related to the capsular polysaccharide of S. pneumoniae type 3. Hexasaccharide β-D-GlcpA-(1[Formula: see text]4)-β-D-Glcp-(1[Formula: see text]3)-β-D-GlcpA-(1[Formula: see text]4)-β-D- Glcp-(1[Formula: see text]3)-β-D-GlcpA-(1[Formula: see text]4)-β-D-Glcp-(1[Formula: see text]O-(CH2)3NH2) (1), comprised of three repeating units, was synthesized via a blockwise strategy employing suitably protected disaccharide building blocks. Carboxylic groups were introduced by selective oxidation with TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) in the last reaction steps. Deprotection afforded target hexasaccharide 1.Key words: oligosaccharide synthesis, Streptococcus pneumoniae type 3, TEMPO oxidation.

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