Triggered and catalyzed self-assembly of hyperbranched DNA structures for logic operations and homogeneous CRET biosensing of microRNA

2016 ◽  
Vol 52 (31) ◽  
pp. 5455-5458 ◽  
Author(s):  
Sai Bi ◽  
Shuzhen Yue ◽  
Qiang Wu ◽  
Jiayan Ye
Keyword(s):  
Self Assembly ◽  
Hybridization Chain Reaction ◽  
Strand Displacement ◽  
Chain Reaction ◽  
Dna Structures ◽  
Catalytic Hairpin Assembly ◽  
Displacement Based ◽  
Logic Operations

Toehold-mediated strand displacement-based nanocircuits are developed by integrating catalytic hairpin assembly with hybridization chain reaction, achieving self-assembly of hyperbranched DNA structures and amplified homogeneous CRET detection of microRNA.

DNA logic assembly powered by a triplex-helix molecular switch for extracellular pH imaging

2018 ◽  
Vol 54 (61) ◽  
pp. 8498-8501 ◽  
Author(s):  
Hongjie Qi ◽  
Shuzhen Yue ◽  
Sai Bi ◽  
Caifeng Ding ◽  
Weiling Song
Keyword(s):  
Self Assembly ◽  
Molecular Switch ◽  
Extracellular Ph ◽  
The Self ◽  
Hybridization Chain Reaction ◽  
Dna Nanostructures ◽  
Chain Reaction ◽  
Molecular Logic ◽  
Ph Imaging ◽  
Logic Operations

A strategy is rationally designed to finely control the hybridization chain reaction (HCR) for the self-assembly of DNA nanostructures by simply changing the pH, which is successfully applied to molecular logic operations and extracellular pH imaging.

Lab in a tube: a fast-assembled colorimetric sensor for highly sensitive detection of oligonucleotides based on a hybridization chain reaction

RSC Advances ◽  
2015 ◽  
Vol 5 (55) ◽  
pp. 44714-44721 ◽  
Author(s):  
Siqi Zhang ◽  
Kun Wang ◽  
Zhenyu Li ◽  
Zhongmin Feng ◽  
Ting Sun
Keyword(s):  
Complex Formation ◽  
Dna Sequence ◽  
Self Assembly ◽  
The Self ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
G Quadruplex ◽  
Colored Product ◽  
Highly Sensitive Detection

Upon adding THBV, the self-assembly of THBV with H1 allows the rest of the DNA sequence of H1 to accelerate H1–H2 complex formation. The G-quadruplex at the end of the H1–H2 complex could catalyze TMB into a colored product.

scholarly journals DNA Origami Model for Simple Image Decoding

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Risheng Wang ◽  
Zhixiang Yin ◽  
Jianzhong Cui ◽  
Jing Yang ◽  
Zhen Tang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Molecular Beacon ◽  
Important Application ◽  
Dna Origami ◽  
Hairpin Structure ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Reaction Solution ◽  
Application Methods ◽  
Image Decoding

DNA origami is the application of self-assembly in nanotechnology. The combination of DNA origami and hybridization chain reaction is one of the important application methods of DNA origami. In this paper, DNA origami is used to design the cipher pattern on the base of origami. The cipher chain, which is put into the reaction solution, hybridizes with the molecular beacon and the hairpin structure that form the cipher pattern to build a DNA origami model that can decode the pattern. The cipher chain consists of the starting chain and the intermediate chain. When the cipher is correct, the cipher chain can open the molecular beacon and the hairpin structure to display the cipher pattern on the origami base in the solution.

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