scholarly journals Glucose-bearing biodegradable poly(amino acid) and poly(amino acid)-poly(ester) conjugates for controlled payload release

2016 ◽  
Vol 4 (12) ◽  
pp. 1792-1801 ◽  
Author(s):  
Mthulisi Khuphe ◽  
Clare S. Mahon ◽  
Paul D. Thornton
Keyword(s):  
Aqueous Solution ◽  
Amino Acid ◽  
Block Copolymers ◽  
Self Assembly ◽  
Ring Opening ◽  
Amphiphilic Block Copolymers ◽  
Biodegradable Poly

The glucoseamine-initiated ring-opening polymerisation of amino acid N-carboxyanhydrides and O-carboxanhydrides to yield amphiphilic block copolymers that are capable of self-assembly in aqueous solution to form well-defined, glucose-presenting, particles is reported.

scholarly journals Bio-Inspired Amphiphilic Block-Copolymers Based on Synthetic Glycopolymer and Poly(Amino Acid) as Potential Drug Delivery Systems

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 183 ◽  
Author(s):  
Mariia Levit ◽  
Natalia Zashikhina ◽  
Alena Vdovchenko ◽  
Anatoliy Dobrodumov ◽  
Natalya Zakharova ◽  
...  
Keyword(s):  
Amino Acid ◽  
Block Copolymers ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Breast Adenocarcinoma ◽  
Hydrodynamic Diameter ◽  
Amphiphilic Copolymers ◽  
Lung Carcinoma Cells ◽  
Biodegradable Poly ◽  
Human Lung Carcinoma

In this work, a method to prepare hybrid amphiphilic block copolymers consisting of biocompatible synthetic glycopolymer with non-degradable backbone and biodegradable poly(amino acid) (PAA) was developed. The glycopolymer, poly(2-deoxy-2-methacrylamido-D-glucose) (PMAG), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Two methods for modifying the terminal dithiobenzoate-group of PMAG was investigated to obtain the macroinitiator bearing a primary aliphatic amino group, which is required for ring-opening polymerization of N-carboxyanhydrides of hydrophobic α-amino acids. The synthesized amphiphilic block copolymers were carefully analyzed using a set of different physico-chemical methods to establish their composition and molecular weight. The developed amphiphilic copolymers tended to self-assemble in nanoparticles of different morphology that depended on the nature of the hydrophobic amino acid present in the copolymer. The hydrodynamic diameter, morphology, and cytotoxicity of polymer particles based on PMAG-b-PAA were evaluated using dynamic light scattering (DLS) and transmission electron microscopy (TEM), as well as CellTiter-Blue (CTB) assay, respectively. The redox-responsive properties of nanoparticles were evaluated in the presence of glutathione taken at different concentrations. Moreover, the encapsulation of paclitaxel into PMAG-b-PAA particles and their cytotoxicity on human lung carcinoma cells (A549) and human breast adenocarcinoma cells (MCF-7) were studied.

Aggregation-induced emission block copolymers based on ring-opening metathesis polymerization

RSC Advances ◽  
2014 ◽  
Vol 4 (93) ◽  
pp. 51194-51200 ◽  
Author(s):  
Yuming Zhao ◽  
Ying Wu ◽  
Guowei Yan ◽  
Ke Zhang
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Ring Opening ◽  
Water Soluble ◽  
Amphiphilic Block Copolymers ◽  
Ring Opening Metathesis Polymerization ◽  
Metathesis Polymerization ◽  
Aggregation Induced Emission ◽  
Selective Solvents ◽  
First Time

AIE amphiphilic block copolymers were developed from ROMP for the first time. By self-assembly in selective solvents, water soluble fluorescent nano-objects were prepared with varied structures including micelles and vesicles.

Compartmentalized nanoparticles in aqueous solution through hierarchical self-assembly of triblock glycopolymers

2018 ◽  
Vol 9 (30) ◽  
pp. 4132-4142 ◽  
Author(s):  
Alberto Piloni ◽  
Andreas Walther ◽  
Martina H. Stenzel
Keyword(s):  
Aqueous Solution ◽  
Block Copolymers ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Functional Materials ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers

Amphiphilic block copolymers can elegantly assemble in water to form well-defined nano-objects and through smart design of the polymers it is possible to efficiently prepare functional materials for biomedical applications such as drug carriers.

Poly(Ethylene Oxide)-B-Poly(ε-Caprolactone) Amphiphilic Block Copolymers: Synthesis and Self-Assembly

2011 ◽  
Vol 284-286 ◽  
pp. 1877-1885
Author(s):  
Ke Xin Kang ◽  
Min Ying Liu ◽  
Qing Xiang Zhao ◽  
Peng Fu ◽  
Xiao Bing Wang
Keyword(s):  
Molecular Weight ◽  
Block Copolymers ◽  
Self Assembly ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Amphiphilic Block Copolymers ◽  
H Nmr ◽  
Transmission Electron ◽  
Particle Size Analyzer ◽  
Anionic Ring

A series of amphiphilic block copolymers mPEO-b-PCL with different PCL molecular weight were successfully prepared by combination of anionic ring-opening polymerization with coordination-insertion ring-opening polymerization. Firstly, the linear mPEO was prepared by anionic ring-opening copolymerization of EO with 2-(2-methoxyethoxy) ethoxide potassium as the small molecule initiators, then the mPEO as the macroinitiator was used to initiate the ring-opening polymerization of CL, in the absence of Sn(Oct)2 as the catalyst, and amphiphilic block copolymers mPEO-b-PCL were obtained. By changing the ratio of monomer and macroinitiator, prepared a series of different molecular weight mPEO-b-PCL. The structure of intermediates and final products were characterized by 1H NMR and GPC. The critical micelle concentration (cmc) of the final copolymer was measured. In addition, the sizes and morphologies of the obtained micelles at different PCL chains were studied with Laser nano-particle size analyzer and transmission electron microscopy (TEM).

scholarly journals Precise Synthesis and Thin Film Self-Assembly of PLLA-b-PS Bottlebrush Block Copolymers

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1412
Author(s):  
Eunkyung Ji ◽  
Cian Cummins ◽  
Guillaume Fleury
Keyword(s):  
Thin Film ◽  
Block Copolymers ◽  
Self Assembly ◽  
Ring Opening ◽  
Periodic Structures ◽  
One Pot ◽  
Ordered Structures ◽  
Carbonyl Chloride ◽  
Thin Film Patterning ◽  
Nanoporous Templates

The ability of bottlebrush block copolymers (BBCPs) to self-assemble into ordered large periodic structures could greatly expand the scope of photonic and membrane technologies. In this paper, we describe a two-step synthesis of poly(l-lactide)-b-polystyrene (PLLA-b-PS) BBCPs and their rapid thin-film self-assembly. PLLA chains were grown from exo-5-norbornene-2-methanol via ring-opening polymerization (ROP) of l-lactide to produce norbornene-terminated PLLA. Norbonene-terminated PS was prepared using anionic polymerization followed by a termination reaction with exo-5-norbornene-2-carbonyl chloride. PLLA-b-PS BBCPs were prepared from these two norbornenyl macromonomers by a one-pot sequential ring opening metathesis polymerization (ROMP). PLLA-b-PS BBCPs thin-films exhibited cylindrical and lamellar morphologies depending on the relative block volume fractions, with domain sizes of 46–58 nm and periodicities of 70–102 nm. Additionally, nanoporous templates were produced by the selective etching of PLLA blocks from ordered structures. The findings described in this work provide further insight into the controlled synthesis of BBCPs leading to various possible morphologies for applications requiring large periodicities. Moreover, the rapid thin film patterning strategy demonstrated (>5 min) highlights the advantages of using PLLA-b-PS BBCP materials beyond their linear BCP analogues in terms of both dimensions achievable and reduced processing time.

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Self-assembly properties of some chiral N-palmitoyl amino acid surfactants in aqueous solution

2008 ◽  
Vol 319 (2) ◽  
pp. 526-533 ◽  
Author(s):  
Mariana Gerova ◽  
Fernanda Rodrigues ◽  
Jean-François Lamère ◽  
Alexander Dobrev ◽  
Suzanne Fery-Forgues
Keyword(s):  
Aqueous Solution ◽  
Amino Acid ◽  
Self Assembly
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