Cellular uptake of drug loaded spider silk particles

2016 ◽  
Vol 4 (10) ◽  
pp. 1515-1523 ◽  
Author(s):  
Martina B. Schierling ◽  
Elena Doblhofer ◽  
Thomas Scheibel
Keyword(s):  
Drug Resistance ◽  
Side Effects ◽  
Cellular Uptake ◽  
Spider Silk ◽  
Medical Therapies

Medical therapies are often accompanied by not-wanted side-effects or, even worse, targeted cells can develop drug resistance leading to an ineffective treatment. Here, it was shown that drugs can be efficiently delivered into and released within cells when spider silk particles were used as a carrier.

scholarly journals Enhanced cellular uptake of engineered spider silk particles

2015 ◽  
Vol 3 (3) ◽  
pp. 543-551 ◽  
Author(s):  
Martina B. Elsner ◽  
Heike M. Herold ◽  
Susanne Müller-Herrmann ◽  
Hendrik Bargel ◽  
Thomas Scheibel
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cellular Uptake ◽  
Drug Delivery Systems ◽  
Spider Silk ◽  
Tissue Cell ◽  
Total Drug ◽  
Specific Targeting ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Drug delivery systems allow tissue/cell specific targeting of drugs in order to reduce total drug amounts administered to an organism and potential side effects upon systemic drug delivery.

Targeted nanoparticles from xyloglucan–doxorubicin conjugate loaded with doxorubicin against drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 26137-26146 ◽  
Author(s):  
Xuan Xie ◽  
Shiying Luo ◽  
Jean Felix Mukerabigwi ◽  
Jian Mei ◽  
Yuannian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Side Effects ◽  
Tumor Cells ◽  
Cellular Uptake ◽  
Drug Delivery Systems ◽  
Drug Resistant ◽  
The Novel ◽  
Targeted Nanoparticles ◽  
Nanoparticle Drug Delivery

The novel targeted Xyloglucan–doxorubicin nanoparticle drug delivery systems (DOX nano-DDSs) exhibited improved cellular uptake, increased accumulation in tumor, higher cytotoxicity against drug resistant tumor cells and reduced side effects.

Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy

2020 ◽  
Vol 27 (13) ◽  
pp. 2118-2132 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Hakan Ozben ◽  
Ferhat Hanikoglu ◽  
Tomris Ozben
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Side Effects ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Chemotherapeutic Agents ◽  
Oxidation Reactions ◽  
Hybrid Compounds ◽  
Induced Apoptosis

: Elevated Reactive Oxygen Species (ROS) generated by the conventional cancer therapies and the endogenous production of ROS have been observed in various types of cancers. In contrast to the harmful effects of oxidative stress in different pathologies other than cancer, ROS can speed anti-tumorigenic signaling and cause apoptosis of tumor cells via oxidative stress as demonstrated in several studies. The primary actions of antioxidants in cells are to provide a redox balance between reduction-oxidation reactions. Antioxidants in tumor cells can scavenge excess ROS, causing resistance to ROS induced apoptosis. Various chemotherapeutic drugs, in their clinical use, have evoked drug resistance and serious side effects. Consequently, drugs having single-targets are not able to provide an effective cancer therapy. Recently, developed hybrid anticancer drugs promise great therapeutic advantages due to their capacity to overcome the limitations encountered with conventional chemotherapeutic agents. Hybrid compounds have advantages in comparison to the single cancer drugs which have usually low solubility, adverse side effects, and drug resistance. This review addresses two important treatments strategies in cancer therapy: oxidative stress induced apoptosis and hybrid anticancer drugs.

Recent Advances in the Rational Drug Design Based on Multi-target Ligands

2020 ◽  
Vol 27 (28) ◽  
pp. 4720-4740 ◽  
Author(s):  
Ting Yang ◽  
Xin Sui ◽  
Bing Yu ◽  
Youqing Shen ◽  
Hailin Cong
Keyword(s):  
Drug Resistance ◽  
Clinical Practice ◽  
Side Effects ◽  
Drug Design ◽  
Rational Drug Design ◽  
Health Conditions ◽  
Pharmacokinetic Parameters ◽  
Single Target ◽  
Rational Drug ◽  
Huge Challenge

Multi-target drugs have gained considerable attention in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance. Single-target drugs, although highly selective, may not necessarily have better efficacy or fewer side effects. Therefore, more attention is being paid to developing drugs that work on multiple targets at the same time, but developing such drugs is a huge challenge for medicinal chemists. Each target must have sufficient activity and have sufficiently characterized pharmacokinetic parameters. Multi-target drugs, which have long been known and effectively used in clinical practice, are briefly discussed in the present article. In addition, in this review, we will discuss the possible applications of multi-target ligands to guide the repositioning of prospective drugs.

Small Molecular Gemcitabine Prodrugs for Cancer Therapy

2020 ◽  
Vol 27 (33) ◽  
pp. 5562-5582 ◽  
Author(s):  
He Miao ◽  
Xuehong Chen ◽  
Yepeng Luan
Keyword(s):  
Drug Resistance ◽  
Side Effects ◽  
Anticancer Drug ◽  
Drug Stability ◽  
Effective Means ◽  
Active Form ◽  
Deoxycytidine Kinase ◽  
High Efficacy ◽  
Pyrimidine Nucleoside ◽  
Design And Synthesis

Gemcitabine as a pyrimidine nucleoside analog anticancer drug has high efficacy for a broad spectrum of solid tumors. Gemcitabine is activated within tumor cells by sequential phosphorylation carried out by deoxycytidine kinase to mono-, di-, and triphosphate nucleotides with the last one as the active form. But the instability, drug resistance and toxicity severely limited its utilization in clinics. In the field of medicinal chemistry, prodrugs have proven to be a very effective means for elevating drug stability and decrease undesirable side effects including the nucleoside anticancer drug such as gemcitabine. Many works have been accomplished in design and synthesis of gemcitabine prodrugs, majority of which were summarized in this review.

scholarly journals Knowledge, attitude, and practice of pharmacy and medical students regarding self-medication, a study in Zabol University of Medical Sciences; Sistan and Baluchestan province in south-east of Iran

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mahmoud Hashemzaei ◽  
Mahdi Afshari ◽  
Zahra Koohkan ◽  
Ali Bazi ◽  
Ramin Rezaee ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Medical Students ◽  
Side Effects ◽  
Drug Information ◽  
Significant Risk ◽  
Disease Recurrence ◽  
Medical Sciences ◽  
Self Medication ◽  
Attitude And Practice ◽  
Knowledge Attitude And Practice

Abstract Background Self-medication is defined as using medicinal products to treat the disorders or symptoms diagnosed by oneself. Although informed self-medication is one of the ways to reduce health care costs, inappropriate self-treatment can pose various risks including drug side effects, recurrence of symptoms, drug resistance, etc. The purpose of this study was to investigate the knowledge, attitude, and practice of pharmacy and medical students toward self-medication. Methods This study was conducted in Zabol University of Medical Sciences in 2018. Overall, 170 pharmacy and medical students were included. A three-part researcher-made questionnaire was designed to address the students’ knowledge, attitude, and practice. Statistical analysis was performed in SPSS 25 software. Results According to the results, 97 (57.1%) students had carried out self-medication within the past 6 months. Overall, the students self-medicated on average 4.2 ± 2.9 times per year. Self-medication was more common in male students (65.4%, P = 0.043). Cold was the most common ailment treated with self-medication (93.2%), and antibiotics (74.4%) were the most commonly used drugs. The primary information sources used by the students were their previous prescriptions (47.4%). Pharmacy students had a higher level of drug information (P < 0.001). There was a statistically significant association between the level of drug information and the tendency for self-medication (P = 0.005). Disease recurrence was the most common negative complication of self-medication. Conclusion There is a need to educate pharmacy and medical students regarding self-medication and its side effects. The high prevalence of self-medication and the overuse of antibiotics can pose a significant risk of drug resistance.

“Dual-Key-and-Lock” dual drug carrier for dual mode imaging guided chemo-photothermal therapy

2020 ◽  
Vol 8 (22) ◽  
pp. 6212-6224
Author(s):  
Feng Tian ◽  
Bin Chi ◽  
Chen Xu ◽  
Caixue Lin ◽  
Zushun Xu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Side Effects ◽  
Photothermal Therapy ◽  
Drug Carrier ◽  
Dual Mode ◽  
Dual Drug

Drug resistance and side effects are the two main problems of chemotherapy.

scholarly journals Platinum Complexes And Their Anti-Tumour Activity Against Chronic Lymphocytic Leukaemia Cells

2015 ◽  
Vol 16 (3) ◽  
pp. 181-186
Author(s):  
Žana Besser Silconi ◽  
Sasa Benazic ◽  
Jelena Milovanovic ◽  
Aleksandar Arsenijevic ◽  
Bojana Stojanovic ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Side Effects ◽  
Chronic Lymphocytic Leukaemia ◽  
Cancer Treatment ◽  
Lymphocytic Leukaemia ◽  
Clinical Stage ◽  
Phenotypic Expression ◽  
Platinum Complexes ◽  
Cancer Drug ◽  
Staging Systems

Abstract Since the discovery of the antitumor activity of cisplatin by Rosenberg and co-workers, the use of metal complexes in cancer treatment has caused a huge interest. Today, platinum-based drugs are part of standard chemotherapy in the management of a variety of ca ncers, germ cell tumours, sarcomas, and lymphomas. Unfortunately, toxicity and drug resistance are major obstacles to wider clinical application of these drugs. Their use is greatly limited by severe side effects such as nephrotoxicity, ototoxicity, and neurotoxicity. Although cisplatin is one of the most successful anticancer drugs to date, its biochemical mechanism of action is still unclear. Cisplatin is generally accepted as having the ability to interact with the purine bases on the DNA, causing DNA damage, interfering with DNA repair mechanisms, and subsequently inducing apoptosis in cancer cells. Chronic lymphocytic leukaemia is a neoplastic B cell lymphoproliferative disease characterized by a highly variable clinical course. Clinical stage at the diagnosis and biological prognostic factors are the important predictors for survival. The Rai and Binet staging systems describe three major prognostic subgroups. Commonly used prognostic biomarkers in chronic lymphocytic leukaemia can be divided into genotypic, DNA-level changes and phenotypic, expression-level changes. For chronic lymphocytic leukaemia, substantial progress in therapy has not been made over the past 40 years. The main goal of future scientific research is to find new platinum complexes that have better efficacy in cancer treatment, the ability to be administered orally, without developing a cancer-drug resistance, and reduced toxic side effects.

scholarly journals Sericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse cancer drug resistance

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 1103-1116 ◽  
Author(s):  
Weihong Guo ◽  
Lizhi Deng ◽  
Jiang Yu ◽  
Zhaoyu Chen ◽  
Yanghee Woo ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cellular Uptake ◽  
Cancer Drug ◽  
Triggered Release ◽  
Cancer Drug Resistance
Sign in / Sign up

Export Citation Format

Share Document