scholarly journals Enhanced cellular uptake of engineered spider silk particles

2015 ◽  
Vol 3 (3) ◽  
pp. 543-551 ◽  
Author(s):  
Martina B. Elsner ◽  
Heike M. Herold ◽  
Susanne Müller-Herrmann ◽  
Hendrik Bargel ◽  
Thomas Scheibel
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cellular Uptake ◽  
Drug Delivery Systems ◽  
Spider Silk ◽  
Tissue Cell ◽  
Total Drug ◽  
Specific Targeting ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Drug delivery systems allow tissue/cell specific targeting of drugs in order to reduce total drug amounts administered to an organism and potential side effects upon systemic drug delivery.

scholarly journals Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Gels ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. 14 ◽  
Author(s):  
Esfandyar Askari ◽  
Amir Seyfoori ◽  
Meitham Amereh ◽  
Sadaf Samimi Gharaie ◽  
Hanieh Sadat Ghazali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
High Capacity ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Post Surgery ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted.

Advances in local and systemic drug delivery systems for post-surgical cancer treatment

2020 ◽  
Vol 8 (37) ◽  
pp. 8507-8518
Author(s):  
Md Aquib ◽  
Ajkia Zaman Juthi ◽  
Muhammad Asim Farooq ◽  
Manasik Gumah Ali ◽  
Alhamzah Hasan Waheed Janabi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Graphical Representation ◽  
Delivery Systems ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Graphical representation of local and systemic drug delivery systems.

scholarly journals Bioadhesive drug delivery systems: Overview and recent advances

2017 ◽  
Vol 6 (3) ◽  
pp. 2016 ◽  
Author(s):  
Devarshi Brahmbhatt
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Formulation Development ◽  
Adhesive Systems ◽  
Specific Targeting ◽  
Recent Advances

Bio adhesive systems have gained growing interest due to its ability to localize the drug delivery along with sustained release. This leads to reduction of side-effects due to non-specific targeting. This review provides an overview of the understanding of bioadhesive drug delivery system along with the recent advances in their formulation development.

scholarly journals AN ASSESSMENT ON BUCCAL MUCOADHESIVE DRUG DELIVERY SYSTEM

2021 ◽  
pp. 66-74
Author(s):  
LEELA LAKSHMI V. ◽  
UMASHANKAR M. S. ◽  
ALAGUSUNDARAM M.
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Mucoadhesive Polymers ◽  
Buccal Drug Delivery ◽  
Delivery Mechanism ◽  
Mucosal Drug Delivery ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Buccal drug delivery system (BDDS) has won a variety of exposure and traction as it possesses plenty of advantages and benefits as evaluate to different mucosal drug delivery systems. Buccal path for systemic drug delivery, the use of mucoadhesive polymers twill significantly increase the efficacy of many tablets, has been of outstanding interest over the previous couple of decades. This article affords a precise of BDDS mechanisms, consisting of a composition of the oral mucosa, delivery mechanism, numerous forms of BDDS, formulation, assessment and application of BDDS. Additionally, this text affords a precis over the patents, advertised products and destiny factors of BDDS. In this evaluation article, we've got tried to assemble the maximum significant reports (1988 to 2021) of formulation, assessment, application, patents of BDDS. This review will help pharmaceutical researchers to clarify the potential of BDDS to overcome the various existing drug delivery dispute like the efficiency of absorption, permeability and bioavailability of drugs.

Targeted nanoparticles from xyloglucan–doxorubicin conjugate loaded with doxorubicin against drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 26137-26146 ◽  
Author(s):  
Xuan Xie ◽  
Shiying Luo ◽  
Jean Felix Mukerabigwi ◽  
Jian Mei ◽  
Yuannian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Side Effects ◽  
Tumor Cells ◽  
Cellular Uptake ◽  
Drug Delivery Systems ◽  
Drug Resistant ◽  
The Novel ◽  
Targeted Nanoparticles ◽  
Nanoparticle Drug Delivery

The novel targeted Xyloglucan–doxorubicin nanoparticle drug delivery systems (DOX nano-DDSs) exhibited improved cellular uptake, increased accumulation in tumor, higher cytotoxicity against drug resistant tumor cells and reduced side effects.

scholarly journals Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

Nanomaterials ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 47
Author(s):  
Xiao Ma ◽  
Yun Gao ◽  
Duoyi Zhao ◽  
Weilin Zhang ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Molecular Mechanisms ◽  
Drug Loading ◽  
Delivery Systems ◽  
Titanium Implants ◽  
Local Drug Delivery ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Titanium implants have always been regarded as one of the gold standard treatments for orthopedic applications, but they still face challenges such as pain, bacterial infections, insufficient osseointegration, immune rejection, and difficulty in personalizing treatment in the clinic. These challenges may lead to the patients having to undergo a painful second operation, along with increased economic burden, but the use of drugs is actively solving these problems. The use of systemic drug delivery systems through oral, intravenous, and intramuscular injection of various drugs with different pharmacological properties has effectively reduced the levels of inflammation, lowered the risk of endophytic bacterial infection, and regulated the progress of bone tumor cells, processing and regulating the balance of bone metabolism around the titanium implants. However, due to the limitations of systemic drug delivery systems—such as pharmacokinetics, and the characteristics of bone tissue in the event of different forms of trauma or disease—sometimes the expected effect cannot be achieved. Meanwhile, titanium implants loaded with drugs for local administration have gradually attracted the attention of many researchers. This article reviews the latest developments in local drug delivery systems in recent years, detailing how various types of drugs cooperate with titanium implants to enhance antibacterial, antitumor, and osseointegration effects. Additionally, we summarize the improved technology of titanium implants for drug loading and the control of drug release, along with molecular mechanisms of bone regeneration and vascularization. Finally, we lay out some future prospects in this field.

Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

2020 ◽  
Vol 21 (11) ◽  
pp. 1084-1098
Author(s):  
Fengqian Chen ◽  
Yunzhen Shi ◽  
Jinming Zhang ◽  
Qi Liu
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Delivery Systems ◽  
Epigenetic Therapy ◽  
Cancer Therapies ◽  
Therapeutic Benefits ◽  
High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

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