A simple label-free aptamer-based method for C-reactive protein detection

2016 ◽  
Vol 8 (21) ◽  
pp. 4177-4180 ◽  
Author(s):  
Bin Wu ◽  
Nandi Chen ◽  
Qing Wang ◽  
Xiaohai Yang ◽  
Kemin Wang ◽  
...  
Keyword(s):  
Protein Detection ◽  
Label Free ◽  
C Reactive Protein ◽  
Reactive Protein

We developed a simple label-free aptamer-based method for C-reactive protein (CRP) detection.

An ultrasensitive label-free immunoassay for C-reactive protein detection in human serum based on electron transfer

2016 ◽  
Vol 8 (32) ◽  
pp. 6202-6207 ◽  
Author(s):  
Xi Zhang ◽  
Rong Hu ◽  
Kunlei Zhang ◽  
Ruyan Bai ◽  
Delei Li ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Human Serum ◽  
Protein Detection ◽  
Electrochemical Immunoassay ◽  
Label Free ◽  
C Reactive Protein ◽  
Serum Samples ◽  
Reactive Protein

A rapid, ultrasensitive, and practical label-free electrochemical immunoassay for measuring C-reactive protein (CRP) in real serum samples was developed.

scholarly journals Demonstration of a Label-Free and Low-Cost Optical Cavity-Based Biosensor Using Streptavidin and C-Reactive Protein

Biosensors ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 4
Author(s):  
Donggee Rho ◽  
Seunghyun Kim
Keyword(s):  
Limit Of Detection ◽  
Point Of Care ◽  
Low Cost ◽  
Optical Cavity ◽  
Sample Volume ◽  
Small Sample ◽  
Label Free ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Cavity Structure

An optical cavity-based biosensor (OCB) has been developed for point-of-care (POC) applications. This label-free biosensor employs low-cost components and simple fabrication processes to lower the overall cost while achieving high sensitivity using a differential detection method. To experimentally demonstrate its limit of detection (LOD), we conducted biosensing experiments with streptavidin and C-reactive protein (CRP). The optical cavity structure was optimized further for better sensitivity and easier fluid control. We utilized the polymer swelling property to fine-tune the optical cavity width, which significantly improved the success rate to produce measurable samples. Four different concentrations of streptavidin were tested in triplicate, and the LOD of the OCB was determined to be 1.35 nM. The OCB also successfully detected three different concentrations of human CRP using biotinylated CRP antibody. The LOD for CRP detection was 377 pM. All measurements were done using a small sample volume of 15 µL within 30 min. By reducing the sensing area, improving the functionalization and passivation processes, and increasing the sample volume, the LOD of the OCB are estimated to be reduced further to the femto-molar range. Overall, the demonstrated capability of the OCB in the present work shows great potential to be used as a promising POC biosensor.

Myocardial Infarction Biomarker C‐reactive Protein Detection on Nanocomposite Aptasensor

2020 ◽  
Author(s):  
Jing Li ◽  
Haitao Li ◽  
Jinpeng Xu ◽  
Xingzhou Zhao ◽  
Shujiang Song ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Protein Detection ◽  
C Reactive Protein ◽  
Reactive Protein

Label-free RNA aptamer-based capacitive biosensor for the detection of C-reactive protein

2010 ◽  
Vol 12 (32) ◽  
pp. 9176 ◽  
Author(s):  
Anjum Qureshi ◽  
Yasar Gurbuz ◽  
Saravan Kallempudi ◽  
Javed H. Niazi
Keyword(s):  
Rna Aptamer ◽  
Label Free ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Capacitive Biosensor

Evaluation of 2-Methacryloyloxyethyl Phosphorylcholine Polymeric Nanoparticle for Immunoassay of C-Reactive Protein Detection

2004 ◽  
Vol 76 (9) ◽  
pp. 2649-2655 ◽  
Author(s):  
Jongwon Park ◽  
Shigeru Kurosawa ◽  
Junji Watanabe ◽  
Kazuhiko Ishihara
Keyword(s):  
Protein Detection ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Polymeric Nanoparticle

Label-free detection of C-reactive protein using reflectometric interference spectroscopy-based sensing system

2012 ◽  
Vol 728 ◽  
pp. 64-68 ◽  
Author(s):  
Hyung Woo Choi ◽  
Yasuhiko Sakata ◽  
Yoshikazu Kurihara ◽  
Tooru Ooya ◽  
Toshifumi Takeuchi
Keyword(s):  
Label Free ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Sensing System ◽  
Reflectometric Interference Spectroscopy ◽  
Label Free Detection

Label-free detection of C-Reactive protein using bioresponsive hydrogel-based surface relief diffraction gratings

2021 ◽  
pp. 113561
Author(s):  
María Isabel Lucío ◽  
Andy Hernández Montoto ◽  
Estrella Fernández ◽  
Sabri Alamri ◽  
Tim Kunze ◽  
...  
Keyword(s):  
Surface Relief ◽  
Diffraction Gratings ◽  
Label Free ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Label Free Detection

scholarly journals Surface Plasmon Resonance for C-Reactive Protein Detection in Human Plasma

2014 ◽  
Vol 05 (03) ◽  
pp. 153-158 ◽  
Author(s):  
Hanen Chammem ◽  
Imen Hafaid ◽  
Olivier Meilhac ◽  
Farid Menaa ◽  
Laurence Mora ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Human Plasma ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Protein Detection ◽  
C Reactive Protein ◽  
Reactive Protein
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