scholarly journals A label-free Sirtuin 1 assay based on droplet-electrospray ionization mass spectrometry

2016 ◽  
Vol 8 (17) ◽  
pp. 3458-3465 ◽  
Author(s):  
Shuwen Sun ◽  
Benjamin C. Buer ◽  
E. Neil G. Marsh ◽  
Robert T. Kennedy
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
High Throughput ◽  
Electrospray Ionization Mass Spectrometry ◽  
Sirtuin 1 ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Label Free ◽  
Ion Suppression ◽  
Free Ion

A reliable, label-free, ion suppression-free Sirtuin 1 assay has been developed. By interfacing multi-well plates to electrospray ionization mass spectrometry by oil-segmented droplets, the assay can be applied for high throughput Sirtuin 1 modulator screening.

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