scholarly journals iSERS microscopy guided by wide field immunofluorescence: analysis of HER2 expression on normal and breast cancer FFPE tissue sections

The Analyst ◽  
2016 ◽  
Vol 141 (17) ◽  
pp. 5113-5119 ◽  
Author(s):  
Xin-Ping Wang ◽  
Yuying Zhang ◽  
Matthias König ◽  
Evanthia Papadopoulou ◽  
Bernd Walkenfort ◽  
...  
Keyword(s):  
Imaging Technique ◽  
Cancer Diagnostics ◽  
Ffpe Tissue ◽  
Wide Field ◽  
Her2 Expression ◽  
Immunofluorescence Analysis ◽  
Tissue Sections ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Surface-enhanced Raman scattering (SERS) microscopy is an emerging imaging technique for tissue-based cancer diagnostics.

scholarly journals Surface enhanced Raman scattering of extracellular vesicles for cancer diagnostics despite isolation dependent lipoprotein contamination

Nanoscale ◽  
2021 ◽  
Author(s):  
Hanna Koster ◽  
Tatu Rojalin ◽  
Alyssa Powell ◽  
Dina Pham ◽  
Rachel Mizenko ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Extracellular Vesicles ◽  
Surface Enhanced Raman Scattering ◽  
Cancer Diagnostics ◽  
Diagnostic Utility ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Particle Counts

Given the emerging diagnostic utility of extracellular vesicles (EVs), it is important to account for non-EV contaminants. Lipoprotein present in EV-enriched isolates may inflate particle counts and decrease sensitivity to...

scholarly journals Surface-enhanced Raman scattering (SERS)–based immunosystem for ultrasensitive detection of the 90K biomarker

2020 ◽  
Vol 412 (27) ◽  
pp. 7659-7667
Author(s):  
Valentina Gallo ◽  
Antonia Lai ◽  
Alessandra Pasquo ◽  
Salvatore Almaviva ◽  
Stefano Iacobelli ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Biological Fluids ◽  
Surface Enhanced Raman Scattering ◽  
Cancer Diagnostics ◽  
Tumour Markers ◽  
Ultrasensitive Detection ◽  
Asymptomatic Patients ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Abstract The research and the individuation of tumour markers in biological fluids are currently one of the main tools to support diagnosis, prognosis, and monitoring of the therapeutic response in oncology. Although the identification of tumour markers in asymptomatic patients is crucial for early diagnosis, its application is still limited by the relatively low sensitivity and the complexity of existing methods (i.e. ELISA, mass spectrometry). We developed an easy, fast, and ultrasensitive surface-enhanced Raman scattering (SERS)–based system, for the detection and quantitation of the LGALS3BP (90K) biomarker that was used as a model, based on the development of antibody-functionalized nanostructured gold surfaces. The detection system was effective for the ultrasensitive detection and characterization of samples of different biochemical compositions. In conclusion, this work could provide the foundation for the development of a medical diagnostic device with the highest predictive power when compared with the methods currently used in cancer diagnostics.

scholarly journals Single-Molecule Nonresonant Wide-Field Surface-Enhanced Raman Scattering from Ferroelectrically Defined Au Nanoparticle Microarrays

ACS Omega ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 3165-3172 ◽  
Author(s):  
Rusul M. Al-Shammari ◽  
Nebras Al-attar ◽  
Michele Manzo ◽  
Katia Gallo ◽  
Brian J. Rodriguez ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Surface Enhanced Raman Scattering ◽  
Au Nanoparticle ◽  
Wide Field ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

scholarly journals A novel liquid biopsy-based approach for highly specific cancer diagnostics: mitigating false responses in assaying patient plasma-derived circulating microRNAs through combined SERS and plasmon-enhanced fluorescence analyses

The Analyst ◽  
2020 ◽  
Vol 145 (12) ◽  
pp. 4173-4180 ◽  
Author(s):  
Adrianna N. Masterson ◽  
Thakshila Liyanage ◽  
Claire Berman ◽  
Hristos Kaimakliotis ◽  
Merrell Johnson ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Liquid Biopsy ◽  
Cancer Diagnostics ◽  
Enhanced Fluorescence ◽  
Circulating Micrornas ◽  
Plasmon Enhanced Fluorescence ◽  
Surface Enhanced ◽  
Specific Cancer ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Novel multimodal assay has been developed to quantify circulating microRNAs through a combined surface-enhanced Raman scattering and plasmon-enhanced fluorescence approach.

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