Highly-sensitive epinephrine sensors based on organic electrochemical transistors with carbon nanomaterial modified gate electrodes

2015 ◽  
Vol 3 (25) ◽  
pp. 6532-6538 ◽  
Author(s):  
Chun Hin Mak ◽  
Caizhi Liao ◽  
Ying Fu ◽  
Meng Zhang ◽  
Chun Yin Tang ◽  
...  
Keyword(s):  
Carbon Nanomaterials ◽  
Carbon Nanomaterial ◽  
Gate Electrodes ◽  
Highly Sensitive ◽  
Organic Electrochemical Transistors

The sensitivity of OECT-based epinephrine sensors has been dramatically improved by modifying carbon nanomaterials on the Pt gate electrodes.

(Invited) Organic Electrochemical Transistors with Plasmonic Gate Electrodes

2021 ◽  
Vol MA2021-02 (30) ◽  
pp. 907-907
Author(s):  
Jayan Thomas ◽  
Jinxin Li ◽  
Sahil Ghate ◽  
Madiyar Foram
Keyword(s):  
Gate Electrodes ◽  
Organic Electrochemical Transistors

Largely Deformable and Highly Sensitive Strain Sensor Using Carbon Nanomaterials

2017 ◽  
Author(s):  
Kanji Yumoto ◽  
Ken Suzuki ◽  
Hideo Miura
Keyword(s):  
Aspect Ratio ◽  
Growth Condition ◽  
Electrical Resistance ◽  
Carbon Nanomaterials ◽  
Flexible Substrate ◽  
Strain Sensor ◽  
Sensitive Strain ◽  
Synthesis Process ◽  
Pressure Sensitivity ◽  
Highly Sensitive

A new type tactile sensor with spatial resolution less than 1 mm and the minimum pressure sensitivity less than 10 kPa was proposed by applying MWCNTs (Multi-Walled Carbon Nanotubes). The sensor was embedded into a highly deformable flexible substrate (PDMS: Polydimethylsiloxane) and the obtained gauge factor of the developed sensor was about 5. Since the electronic properties of MWCNTs vary drastically depending on their deformation under mechanical stress, it is important to make appropriate aspect ratio of MWCNTs for improving their stress-sensitivity. The aspect ratio of MWCNTs are mainly dominated by their growth condition such as the average thickness of catalyst layer, growth temperature, pressure of resource gases and so on. Thus, the optimum growth condition was investigated for forming the MWCNTs with high aspect ratio, in other words, high pressure sensitivity. In addition, in this study, the authors fabricated high quality carbon nano-materials to develop highly sensitive strain sensor. A thermal CVD synthesis process of MWCNTs was developed by using acetylene gas. After the synthesis of MWCNTs, flexible isolation material (PDMS) was coated around the grown MWCNT. Then, the interconnection film was deposited by sputtering. After that, PDMS was coated again to fabricate an upper protection layer. Finally, the bottom interconnection layer was sputtered and patterned. The change of the electrical resistance of the grown MWCNTs was measured by applying a compression test in the load range from 0 to 10 mN. It was found that the electrical resistance of the MWCNTs bundle increased almost linearly with the applied compressive load and this sensor showed the high load sensitivity of 10 mN that is higher than human fingers.

scholarly journals Toxicity of Carbon Nanomaterials and Their Potential Application as Drug Delivery Systems: In Vitro Studies in Caco-2 and MCF-7 Cell Lines

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1617
Author(s):  
Rosa Garriga ◽  
Tania Herrero-Continente ◽  
Miguel Palos ◽  
Vicente L. Cebolla ◽  
Jesús Osada ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Carbon Nanomaterials ◽  
Chemotherapeutic Agents ◽  
Breast Adenocarcinoma ◽  
In Vitro Toxicity ◽  
Carbon Nanomaterial ◽  
Carbon Nanohorns ◽  
Mcf 7

Carbon nanomaterials have attracted increasing attention in biomedicine recently to be used as drug nanocarriers suitable for medical treatments, due to their large surface area, high cellular internalization and preferential tumor accumulation, that enable these nanomaterials to transport chemotherapeutic agents preferentially to tumor sites, thereby reducing drug toxic side effects. However, there are widespread concerns on the inherent cytotoxicity of carbon nanomaterials, which remains controversial to this day, with studies demonstrating conflicting results. We investigated here in vitro toxicity of various carbon nanomaterials in human epithelial colorectal adenocarcinoma (Caco-2) cells and human breast adenocarcinoma (MCF-7) cells. Carbon nanohorns (CNH), carbon nanotubes (CNT), carbon nanoplatelets (CNP), graphene oxide (GO), reduced graphene oxide (GO) and nanodiamonds (ND) were systematically compared, using Pluronic F-127 dispersant. Cell viability after carbon nanomaterial treatment followed the order CNP < CNH < RGO < CNT < GO < ND, being the effect more pronounced on the more rapidly dividing Caco-2 cells. CNP produced remarkably high reactive oxygen species (ROS) levels. Furthermore, the potential of these materials as nanocarriers in the field of drug delivery of doxorubicin and camptothecin anticancer drugs was also compared. In all cases the carbon nanomaterial/drug complexes resulted in improved anticancer activity compared to that of the free drug, being the efficiency largely dependent of the carbon nanomaterial hydrophobicity and surface chemistry. These fundamental studies are of paramount importance as screening and risk-to-benefit assessment towards the development of smart carbon nanomaterial-based nanocarriers.

scholarly journals Commitment of Autologous Human Multipotent Stem Cells on Biomimetic Poly-L-Lactic Acid-Based Scaffolds Is Strongly Influenced by Structure and Concentration of Carbon Nanomaterial

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 415
Author(s):  
Marika Tonellato ◽  
Monica Piccione ◽  
Matteo Gasparotto ◽  
Pietro Bellet ◽  
Lucia Tibaudo ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Carbon Nanomaterials ◽  
Expression Patterns ◽  
Pcr Analysis ◽  
Marker Genes ◽  
Carbon Nanomaterial ◽  
Multipotent Stem Cells ◽  
Cell Lineages ◽  
Qrt Pcr ◽  
Nanocomposite Scaffolds

Nanocomposite scaffolds combining carbon nanomaterials (CNMs) with a biocompatible matrix are able to favor the neuronal differentiation and growth of a number of cell types, because they mimic neural-tissue nanotopography and/or conductivity. We performed comparative analysis of biomimetic scaffolds with poly-L-lactic acid (PLLA) matrix and three different p-methoxyphenyl functionalized carbon nanofillers, namely, carbon nanotubes (CNTs), carbon nanohorns (CNHs), and reduced graphene oxide (RGO), dispersed at varying concentrations. qRT-PCR analysis of the modulation of neuronal markers in human circulating multipotent cells cultured on nanocomposite scaffolds showed high variability in their expression patterns depending on the scaffolds’ inhomogeneities. Local stimuli variation could result in a multi- to oligopotency shift and commitment towards multiple cell lineages, which was assessed by the qRT-PCR profiling of markers for neural, adipogenic, and myogenic cell lineages. Less conductive scaffolds, i.e., bare poly-L-lactic acid (PLLA)-, CNH-, and RGO-based nanocomposites, appeared to boost the expression of myogenic-lineage marker genes. Moreover, scaffolds are much more effective on early commitment than in subsequent differentiation. This work suggests that biomimetic PLLA carbon-nanomaterial (PLLA-CNM) scaffolds combined with multipotent autologous cells can represent a powerful tool in the regenerative medicine of multiple tissue types, opening the route to next analyses with specific and standardized scaffold features.

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