Polymeric complex micelles based on the double-hydrazone linkage and dual drug-loading strategy for pH-sensitive docetaxel delivery

2016 ◽  
Vol 4 (6) ◽  
pp. 1122-1133 ◽  
Author(s):  
Zhihui Su ◽  
Yanchao Liang ◽  
Yao Yao ◽  
Tianqi Wang ◽  
Na Zhang
Keyword(s):  
Drug Loading ◽  
Ph Sensitive ◽  
Polymeric Complex ◽  
Loading Patterns ◽  
First Time ◽  
Complex Micelles ◽  
Dual Drug

Complex micelles, which integrated double-hydrazone linkage and dual drug-loading patterns, were constructed for the first time.

scholarly journals Cyclodextrin-Based Hybrid Polymeric Complex to Overcome Dual Drug Resistance Mechanisms for Cancer Therapy

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1254
Author(s):  
Lingjie Ke ◽  
Zhiguo Li ◽  
Xiaoshan Fan ◽  
Xian Jun Loh ◽  
Hongwei Cheng ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Gene Delivery ◽  
Cell Membrane ◽  
Inclusion Complex ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Resistance Mechanisms ◽  
Polymeric Complex ◽  
Cavity Structure ◽  
Dual Drug

Drug resistance always reduces the efficacy of chemotherapy, and the classical mechanisms of drug resistance include drug pump efflux and anti-apoptosis mediators-mediated non-pump resistance. In addition, the amphiphilic polymeric micelles with good biocompatibility and high stability have been proven to deliver the drug molecules inside the cavity into the cell membrane regardless of the efflux of the cell membrane pump. We designed a cyclodextrin (CD)-based polymeric complex to deliver chemotherapeutic doxorubicin (DOX) and Nur77ΔDBD gene for combating pumps and non-pump resistance simultaneously. The natural cavity structure of the polymeric complex, which was comprised with β-cyclodextrin-graft-(poly(ε-caprolactone)-adamantly (β-CD-PCL-AD) and β-cyclodextrin-graft-(poly(ε-caprolactone)-poly(2-(dimethylamino) ethyl methacrylate) (β-CD-PCL-PDMAEMA), can achieve the efficient drug loading and delivery to overcome pump drug resistance. The excellent Nur77ΔDBD gene delivery can reverse Bcl-2 from the tumor protector to killer for inhibiting non-pump resistance. The presence of terminal adamantyl (AD) could insert into the cavity of β-CD-PCL-PDMAEMA via host-guest interaction, and the releasing rate of polymeric inclusion complex was higher than that of the individual β-CD-PCL-PDMAEMA. The polymeric inclusion complex can efficiently deliver the Nur77ΔDBD gene than polyethylenimine (PEI-25k), which is a golden standard for nonviral vector gene delivery. The higher transfection efficacy, rapid DOX cellular uptake, and significant synergetic tumor cell viability inhibition were achieved in a pump and non-pump drug resistance cell model. The combined strategy with dual drug resistance mechanisms holds great potential to combat drug-resistant cancer.

Polymeric complex micelles with double drug-loading strategies for folate-mediated paclitaxel delivery

2015 ◽  
Vol 131 ◽  
pp. 191-201 ◽  
Author(s):  
Min Li ◽  
Yongjun Liu ◽  
Lixia Feng ◽  
Fengxi Liu ◽  
Li Zhang ◽  
...  
Keyword(s):  
Drug Loading ◽  
Polymeric Complex ◽  
Complex Micelles

scholarly journals Preparation of a Novel Thiol Surface Modifier and Fe3O4 Drug Loading Agent as well as Releasing under pH-Sensitivity

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Wang Ya-zhen ◽  
Wu Xue-ying ◽  
Di Yu-tao ◽  
Lan Tian-yu ◽  
Zu Li-wu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Thiol Group ◽  
Ph Sensitive ◽  
Surface Modifier ◽  
Novel Drug ◽  
First Time

In this paper, in order to take advantage of the combination between magnetic nano-Fe3O4 and surface modifier, a pH-sensitive drug delivery system that could effectively deliver doxorubicin (DOX) to tumor tissue was constructed. The novel drug delivery system named Fe3O4-TIPTS-g-(PEI-co-PEG) was prepared through three steps. The first step, a surface modifier with the thiol group, thiohydrazide-iminopropyltriethoxysilane surface modifier (named TIPTS), was synthesized for the first time. The second step, Fe3O4-TIPTS was synthesized by treating nano-Fe3O4 with TIPTS. The last step, Fe3O4-TIPTS-g-(PEI-co-PEG) was synthesized in the presence of the Fe3O4-TIPTS, polyethyleneimine (PEI), and polyethylene glycol (PEG) by mercapto-initiated radical polymerization. Among them, magnetic nanoparticles (MNPs) were used as magnetically responsive carriers, PEG was the surface-modifying compound, and PEI was the drug loading site which primary amine reacts with doxorubicin (DOX). Targeted nanoparticles were considerably stabilize in various physiological solutions and exhibited pH-sensitive performance in drug release. Thence, Fe3O4-TIPTS-g-(PEI-co-PEG) is a promising nanocarrier for targeting tumor therapy.

Two-stage pH-sensitive doxorubicin hydrochloride loaded core–shell nanoparticles with dual drug-loading strategies for the potential anti-tumor treatment

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 104049-104066 ◽  
Author(s):  
Xiaoyue Yu ◽  
Bo Zhang ◽  
Tianqi Wang ◽  
Jing Zhang ◽  
Shengjun Mu ◽  
...  
Keyword(s):  
Drug Loading ◽  
Ph Sensitive ◽  
Core Shell ◽  
Doxorubicin Hydrochloride ◽  
Tumor Treatment ◽  
Two Stage ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Dual Drug

Two-stage pH-sensitive DOX·HCl loaded core–shell nanoparticles (CPOD) with dual drug-loading strategies showed pretty in vivo anti-tumor efficacy.

scholarly journals Co-delivery of 5-fluorodeoxyuridine and doxorubicin via gold nanoparticle equipped with affibody-DNA hybrid strands for targeted synergistic chemotherapy of HER2 overexpressing breast cancer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Chao Zhang ◽  
Fanghua Zhang ◽  
Mengnan Han ◽  
Xuming Wang ◽  
Jie Du ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antitumor Activity ◽  
Solid Phase ◽  
Clinical Care ◽  
Drug Loading ◽  
Her2 Positive ◽  
Apoptosis Pathway ◽  
Phase Synthesis ◽  
Drug Nanocarriers ◽  
Dual Drug

AbstractCombination chemotherapy is still of great importance as part of the standard clinical care for patients with HER2 positive breast cancer. As an attractive component, gold nanoparticles (AuNPs) have been extensively studied as biosafety nanomaterials, but they are rarely explored as drug nanocarriers for targeted co-delivery of multiple chemotherapeutics. Herein, a novel affibody-DNA hybrid strands modified AuNPs were fabricated for co-loading nucleoside analogue (5-fluorodeoxyuridine, FUdR) and anthracycline (doxorubicin, Dox). FUdRs were integrated into DNA hybrid strands decorated on AuNPs by DNA solid phase synthesis, and Dox molecules were intercalated into their duplex regions. Affibody molecules coupled to the DNA hybrid strands were distributed the surface of AuNPs, giving them targeting for HER2. The new dual-drug-containing affibody-DNA-AuNPs (Dox@affi-F/AuNPs) owned compact and stable spherical nanostructures, and precise drug loading. Cytotoxicity tests demonstrated that these nanoparticles caused a higher inhibition in HER2 overexpressing breast cancer cells, and showed better synergistic antitumor activity than simple mixture of the two drugs. The related mechanistic studies proved that Dox@affi-F/AuNPs achieved a remarkable combined antitumor activity of Dox and FUdR by promoting more cells to enter apoptosis pathway. Our work provided a nanomedicine platform for targeted co-delivery of nucleoside analog therapeutics and anthracycline anticancer drugs to achieve synergistic treatment of HER2+ cancer.

scholarly journals Solvent-Free Processing of Drug-Loaded Poly(ε-Caprolactone) Scaffolds with Tunable Macroporosity by Combination of Supercritical Foaming and Thermal Porogen Leaching

Polymers ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 159
Author(s):  
Víctor Santos-Rosales ◽  
Inés Ardao ◽  
Leticia Goimil ◽  
Jose Luis Gomez-Amoza ◽  
Carlos A. García-González
Keyword(s):  
Bone Repair ◽  
Drug Loading ◽  
Ammonium Bicarbonate ◽  
Bone Diseases ◽  
Solvent Free ◽  
Bone Integration ◽  
Bioactive Agents ◽  
First Time ◽  
Supercritical Foaming ◽  
Foaming Technology

Demand of scaffolds for hard tissue repair increases due to a higher incidence of fractures related to accidents and bone-diseases that are linked to the ageing of the population. Namely, scaffolds loaded with bioactive agents can facilitate the bone repair by favoring the bone integration and avoiding post-grafting complications. Supercritical (sc-)foaming technology emerges as a unique solvent-free approach for the processing of drug-loadenu7d scaffolds at high incorporation yields. In this work, medicated poly(ε-caprolactone) (PCL) scaffolds were prepared by sc-foaming coupled with a leaching process to overcome problems of pore size tuning of the sc-foaming technique. The removal of the solid porogen (BA, ammonium bicarbonate) was carried out by a thermal leaching taking place at 37 °C and in the absence of solvents for the first time. Macroporous scaffolds with dual porosity (50–100 µm and 200–400 µm ranges) were obtained and with a porous structure directly dependent on the porogen content used. The processing of ketoprofen-loaded scaffolds using BA porogen resulted in drug loading yields close to 100% and influenced its release profile from the PCL matrix to a relevant clinical scenario. A novel solvent-free strategy has been set to integrate the incorporation of solid porogens in the sc-foaming of medicated scaffolds.

LDH-doped electrospun short fibers enable dual drug loading and multistage release for chemotherapy of drug-resistant cancer cells

2021 ◽  
Author(s):  
Yupei Ma ◽  
Du Li ◽  
Yunchao Xiao ◽  
Zhijun OuYang ◽  
Mingwu Shen ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Cancer Chemotherapy ◽  
Side Effect ◽  
Drug Loading ◽  
Adverse Side Effect ◽  
Drug Resistant ◽  
Short Fibers ◽  
Dual Drug

Conventional cancer chemotherapy is facing difficulties in improving the bioavailability, overcoming the severe adverse side effect of chemotherapeutics and reversing the multidrug resistance of cancer cells. To address these challenges,...

A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery

2017 ◽  
Vol 533 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Jie Hou ◽  
Chunlei Guo ◽  
Yuzhi Shi ◽  
Ergang Liu ◽  
Weibing Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
High Drug ◽  
Hybrid Nanoparticle ◽  
High Drug Loading

pH-sensitive polyion complex micelles for tunable intracellular drug delivery

2015 ◽  
Vol 213 ◽  
pp. e55
Author(s):  
Jinjin Chen ◽  
Ying Zhang ◽  
Jianxun Ding ◽  
Chunsheng Xiao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Intracellular Drug Delivery ◽  
Complex Micelles
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