Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings

2015 ◽  
Vol 3 (45) ◽  
pp. 8771-8774 ◽  
Author(s):  
Yue Shi ◽  
Vinh X. Truong ◽  
Ketav Kulkarni ◽  
Yue Qu ◽  
George P. Simon ◽  
...  
Keyword(s):  
Network Structure ◽  
Wound Dressings ◽  
Triggered Release ◽  
In Situ Forming ◽  
Hydrogel Network

Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure.

scholarly journals Photo-triggered release of an antibiotic from an in situ forming hydrogel for antibacterial wound dressings

2016 ◽  
Vol 4 ◽  
Author(s):  
Shi Yue ◽  
Truong Vinh ◽  
Kulkarni Ketav ◽  
Qu Yue ◽  
Simon George ◽  
...  
Keyword(s):  
Wound Dressings ◽  
Triggered Release ◽  
In Situ Forming

Enzyme-catalyzed in situ forming gelatin hydrogels as bioactive wound dressings: effects of fibroblast delivery on wound healing efficacy

2014 ◽  
Vol 2 (44) ◽  
pp. 7712-7718 ◽  
Author(s):  
Yunki Lee ◽  
Jin Woo Bae ◽  
Jin Woo Lee ◽  
Wonhee Suh ◽  
Ki Dong Park
Keyword(s):  
Wound Healing ◽  
Wound Dressings ◽  
Wound Treatment ◽  
In Situ Forming

Wound treatment using injectable or sprayable fibroblast-encapsulated GH-hydrogels.

Mussel-inspired in situ forming adhesive hydrogels with anti-microbial and hemostatic capacities for wound healing

2018 ◽  
Vol 33 (7) ◽  
pp. 915-923 ◽  
Author(s):  
Xiaoman Han ◽  
Guihua Meng ◽  
Qian Wang ◽  
Lin Cui ◽  
Hao Wang ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Phosphate Buffer Solution ◽  
Wound Dressings ◽  
Buffer Solution ◽  
Adhesion Properties ◽  
H Nmr ◽  
Chemical Structures ◽  
In Situ Forming ◽  
Ft Ir

All kinds of commercially available wound dressings are clinically used as fleshly obstacles and therapeutic materials in opposition to microbial incursion. Few researches focused on effective-bleeding and anti-bacteria at the same time. In order to better solve this problem, two hydrogels were synthetized in this study. One is phosphate buffer solution-activated dopamine-modified-γ-poly glutamic acid (PBS-PD) hydrogel, the other one is cirsium setosum extracts-activated dopamine-modified-γ-poly glutamic acid (CSE-PD) hydrogel. The two hydrogels are prepared by applying an enzyme-catalyzed crosslinking means in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The chemical structures were characterized through 1H-NMR and FT-IR. In conclusion, both PBS-PD and CSE-PD hydrogels exhibit superior tissue adhesion properties, and remarkable anti-infection quality. In addition, these two hydrogels manifest prominent hemostatic efficiency. The bio adhesion performance can achieve 30 kPa, meanwhile the CSE-PD hydrogels show good germicidal properties, and the antibacterial rate can reach 98%. The hydrogels could reduce blood loss without any obvious side effect, and present a new prospect in the field of hemostasis rapidly.

Injectable in-situ Forming Depot Of Doxycycline Hyclate/α-Cyclodextrin Complex using PLGA for Periodontitis Treatment: Preparation, Charac-terization, and In-Vitro Evaluation

2020 ◽  
Vol 17 ◽  
Author(s):  
Elham Khodaverdi ◽  
Farhad Eisvand ◽  
Mohammad Sina Nezami ◽  
Seyedeh Nesa Rezaeian Shiadeh ◽  
Hossein Kamali ◽  
...  
Keyword(s):  
Complex Form ◽  
Docking Studies ◽  
Morphological Properties ◽  
Burst Release ◽  
Cyclodextrin Complex ◽  
Doxycycline Hyclate ◽  
Scanning Calorimetry ◽  
In Situ Forming

Background:: Doxycycline (DOX) is used in treating a bacterial infection, especially for periodontitis treatment. Objective: To reduce irritation of DOX for subgingival administration and increase the chemical stability and against enzy-matic, the complex of α-cyclodextrin with DOX was prepared and loaded into injectable in situ forming implant based on PLGA. Methods:: FTIR, molecular docking studies, X-ray diffraction, and differential scanning calorimetry was performed to char-acterize the DOX/α-cyclodextrin complex. Finally, the in-vitro drug release and modeling, morphological properties, and cellular cytotoxic effects were also evaluated. Results:: The stability of DOX was improved with complex than pure DOX. The main advantage of the complex is the al-most complete release (96.31 ± 2.56 %) of the drug within 14 days of the implant, whereas in the formulation containing the pure DOX and the physical mixture the DOX with α-cyclodextrin release is reached to 70.18 ± 3.61 % and 77.03 ± 3.56 %, respectively. This trend is due to elevate of DOX stability in the DOX/ α-cyclodextrin complex form within PLGA implant that confirmed by the results of stability. Conclusion:: Our results were indicative that the formulation containing DOX/α-cyclodextrin complex was biocompatible and sustained-release with minimum initial burst release.

Enhanced drug loading of in situ forming gels for oral mucositis pain control

2021 ◽  
Vol 595 ◽  
pp. 120225
Author(s):  
Tingting Li ◽  
Rajesh V. Lalla ◽  
Diane J. Burgess
Keyword(s):  
Oral Mucositis ◽  
Pain Control ◽  
Drug Loading ◽  
In Situ Forming

Tailoring martensitic transformation and mechanical properties of Ti–Ni composite reinforced by network structure of in-situ TiB and La2O3 phase

Vacuum ◽  
2021 ◽  
Vol 184 ◽  
pp. 109894 ◽  
Author(s):  
Xiaoyang Yi ◽  
Haizhen Wang ◽  
Kuishan Sun ◽  
Guijuan Shen ◽  
Xianglong Meng ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Martensitic Transformation ◽  
Network Structure

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

scholarly journals Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

2020 ◽  
Author(s):  
Isabel Pereira ◽  
José Eduardo Pereira ◽  
Luís Maltez ◽  
Alexandra Rodrigues ◽  
Catarina Rodrigues ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Substitute ◽  
Bone Substitutes ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Micro Computed Tomography ◽  
Synthetic Bone Substitute ◽  
In Situ Forming ◽  
Bioactive Agents ◽  
In Situ Forming Hydrogels

Abstract The development of injectable bone substitutes (IBS) have obtained great importance in the bone regeneration field, as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies. In this scenario, the association of injectable hydrogels and bone graft granules is emerging as a well-established trend. Particularly, in situ forming hydrogels have arisen as a new IBS generation. An in situ forming and injectable dextrin-based hydrogel (HG) was developed, aiming to act as a carrier of granular bone substitutes and bioactive agents. In this work, the HG was associated to a granular bone substitute (Bonelike®) and implanted in goat critical-sized calvarial defects (14 mm) for 3, 6 and 12 weeks. The results showed that HG improved the handling properties of the Bonelike® granules and did not affect its osteoconductive features, neither impairing the bone regeneration process. Human multipotent mesenchymal stromal cells from the umbilical cord, extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the IBS. These bioactive agents did not enhance the new bone formation significantly under the conditions tested, according to micro-computed tomography and histological analysis.

scholarly journals Impact of octreotide counterion nature on the long-term stability and release kinetics from an in situ forming depot technology

2021 ◽  
Vol 336 ◽  
pp. 457-468
Author(s):  
Charlotte Molinier ◽  
Marina Picot-Groz ◽  
Océane Malval ◽  
Sophie Le Lamer-Déchamps ◽  
Joël Richard ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Term Stability ◽  
Long Term Stability ◽  
In Situ Forming ◽  
Counterion Nature
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