Enzyme-catalyzed in situ forming gelatin hydrogels as bioactive wound dressings: effects of fibroblast delivery on wound healing efficacy

2014 ◽  
Vol 2 (44) ◽  
pp. 7712-7718 ◽  
Author(s):  
Yunki Lee ◽  
Jin Woo Bae ◽  
Jin Woo Lee ◽  
Wonhee Suh ◽  
Ki Dong Park
Keyword(s):  
Wound Healing ◽  
Wound Dressings ◽  
Wound Treatment ◽  
In Situ Forming

Wound treatment using injectable or sprayable fibroblast-encapsulated GH-hydrogels.

Moist-Retaining, Self-Recoverable, Bioadhesive, and Transparent in Situ Forming Hydrogels To Accelerate Wound Healing

2020 ◽  
Vol 12 (2) ◽  
pp. 2023-2038 ◽  
Author(s):  
Jun Li ◽  
Fan Yu ◽  
Gong Chen ◽  
Jia Liu ◽  
Xiao-Long Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Accelerate Wound Healing ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

The in situ synthesis of Ag/amino acid biopolymer hydrogels as mouldable wound dressings

2015 ◽  
Vol 51 (87) ◽  
pp. 15862-15865 ◽  
Author(s):  
Zhenzhu Zhang ◽  
Ting He ◽  
Mengying Yuan ◽  
Rujuan Shen ◽  
Liu Deng ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amino Acid ◽  
In Situ Synthesis ◽  
Wound Dressings ◽  
Supramolecular Hydrogel ◽  
Green Strategy

Monodispersed AgNPs were in situ fabricated in a hybrid supramolecular hydrogel via a green strategy. The as-prepared nanocomposite has been proved to be a mouldable wound healing biomaterial.

In Situ Forming and Rutin-Releasing Chitosan Hydrogels As Injectable Dressings for Dermal Wound Healing

2011 ◽  
Vol 12 (8) ◽  
pp. 2872-2880 ◽  
Author(s):  
Ngoc Quyen Tran ◽  
Yoon Ki Joung ◽  
Eugene Lih ◽  
Ki Dong Park
Keyword(s):  
Wound Healing ◽  
Dermal Wound Healing ◽  
In Situ Forming ◽  
Chitosan Hydrogels ◽  
Dermal Wound

In situ forming and reactive oxygen species-scavenging gelatin hydrogels for enhancing wound healing efficacy

2020 ◽  
Vol 103 ◽  
pp. 142-152 ◽  
Author(s):  
Phuong Le Thi ◽  
Yunki Lee ◽  
Dieu Linh Tran ◽  
Thai Thanh Hoang Thi ◽  
Jeon Il Kang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
In Situ Forming

One-pot, self-catalyzed synthesis of self-adherent hydrogels for photo-thermal, antimicrobial wound treatment

2021 ◽  
Vol 9 (1) ◽  
pp. 159-169
Author(s):  
Pengfei Li ◽  
Wenqi She ◽  
Yadong Luo ◽  
Dengfeng He ◽  
Jiali Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressings ◽  
Wound Treatment ◽  
One Pot

Self-adhering hydrogels are promising materials to be employed as wound dressings, because they can be used for wound healing without the necessity of additional stitching.

Mussel-inspired in situ forming adhesive hydrogels with anti-microbial and hemostatic capacities for wound healing

2018 ◽  
Vol 33 (7) ◽  
pp. 915-923 ◽  
Author(s):  
Xiaoman Han ◽  
Guihua Meng ◽  
Qian Wang ◽  
Lin Cui ◽  
Hao Wang ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Phosphate Buffer Solution ◽  
Wound Dressings ◽  
Buffer Solution ◽  
Adhesion Properties ◽  
H Nmr ◽  
Chemical Structures ◽  
In Situ Forming ◽  
Ft Ir

All kinds of commercially available wound dressings are clinically used as fleshly obstacles and therapeutic materials in opposition to microbial incursion. Few researches focused on effective-bleeding and anti-bacteria at the same time. In order to better solve this problem, two hydrogels were synthetized in this study. One is phosphate buffer solution-activated dopamine-modified-γ-poly glutamic acid (PBS-PD) hydrogel, the other one is cirsium setosum extracts-activated dopamine-modified-γ-poly glutamic acid (CSE-PD) hydrogel. The two hydrogels are prepared by applying an enzyme-catalyzed crosslinking means in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The chemical structures were characterized through 1H-NMR and FT-IR. In conclusion, both PBS-PD and CSE-PD hydrogels exhibit superior tissue adhesion properties, and remarkable anti-infection quality. In addition, these two hydrogels manifest prominent hemostatic efficiency. The bio adhesion performance can achieve 30 kPa, meanwhile the CSE-PD hydrogels show good germicidal properties, and the antibacterial rate can reach 98%. The hydrogels could reduce blood loss without any obvious side effect, and present a new prospect in the field of hemostasis rapidly.

scholarly journals Development of an in-situ forming, self-healing scaffold for dermal wound healing: in-vivo and in-vivo studies

2021 ◽  
pp. 112263
Author(s):  
Swati Sharma ◽  
Harishkumar Madhyastha ◽  
K. Laxmi Swetha ◽  
Kavya Sree Maravajjala ◽  
Archana Singh ◽  
...  
Keyword(s):  
Wound Healing ◽  
In Vivo Studies ◽  
Self Healing ◽  
Dermal Wound Healing ◽  
In Situ Forming ◽  
Dermal Wound

scholarly journals Sulfated Polysaccharides from Marine Algae as a Basis of Modern Biotechnologies for Creating Wound Dressings: Current Achievements and Future Prospects

Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 301 ◽  
Author(s):  
Boris G. Andryukov ◽  
Natalya N. Besednova ◽  
Tatyana A. Kuznetsova ◽  
Tatyana S. Zaporozhets ◽  
Svetlana P. Ermakova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Trial Data ◽  
Biological Properties ◽  
Biologically Active ◽  
Wound Dressings ◽  
Sulfated Polysaccharides ◽  
Wound Treatment ◽  
Accelerate Wound Healing ◽  
Therapeutic Tools ◽  
Scar Mark

Wound healing involves a complex cascade of cellular, molecular, and biochemical responses and signaling processes. It consists of successive interrelated phases, the duration of which depends on a multitude of factors. Wound treatment is a major healthcare issue that can be resolved by the development of effective and affordable wound dressings based on natural materials and biologically active substances. The proper use of modern wound dressings can significantly accelerate wound healing with minimum scar mark. Sulfated polysaccharides from seaweeds, with their unique structures and biological properties, as well as with a high potential to be used in various wound treatment methods, now undoubtedly play a major role in innovative biotechnologies of modern natural interactive dressings. These natural biopolymers are a novel and promising biologically active source for designing wound dressings based on alginates, fucoidans, carrageenans, and ulvans, which serve as active and effective therapeutic tools. The goal of this review is to summarize available information about the modern wound dressing technologies based on seaweed-derived polysaccharides, including those successfully implemented in commercial products, with a focus on promising and innovative designs. Future perspectives for the use of marine-derived biopolymers necessitate summarizing and analyzing results of numerous experiments and clinical trial data, developing a scientifically substantiated approach to wound treatment, and suggesting relevant practical recommendations.

Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings

2015 ◽  
Vol 3 (45) ◽  
pp. 8771-8774 ◽  
Author(s):  
Yue Shi ◽  
Vinh X. Truong ◽  
Ketav Kulkarni ◽  
Yue Qu ◽  
George P. Simon ◽  
...  
Keyword(s):  
Network Structure ◽  
Wound Dressings ◽  
Triggered Release ◽  
In Situ Forming ◽  
Hydrogel Network

Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure.

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