scholarly journals Biomimetic microbeads containing a chondroitin sulfate/chitosan polyelectrolyte complex for cell-based cartilage therapy

2015 ◽  
Vol 3 (40) ◽  
pp. 7920-7929 ◽  
Author(s):  
Ethan L. H. Daley ◽  
Rhima M. Coleman ◽  
Jan P. Stegemann
Keyword(s):  
Tissue Engineering ◽  
Chondroitin Sulfate ◽  
Polyelectrolyte Complex ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Cartilage Therapy

Cell-encapsulating microbeads containing a biomimetic chondroitin sulfate–chitosan polyelectrolyte complex for cartilage tissue engineering.

scholarly journals A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate

2014 ◽  
Vol 10 (1) ◽  
pp. 214-223 ◽  
Author(s):  
Peter A. Levett ◽  
Ferry P.W. Melchels ◽  
Karsten Schrobback ◽  
Dietmar W. Hutmacher ◽  
Jos Malda ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

Temporal MRI characterization of gelatin/hyaluronic acid/chondroitin sulfate sponge for cartilage tissue engineering

2012 ◽  
Vol 101A (8) ◽  
pp. 2174-2180 ◽  
Author(s):  
Cheng-Hung Chou ◽  
Herng-Sheng Lee ◽  
Tiing Yee Siow ◽  
Ming-Huang Lin ◽  
Amit Kumar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

scholarly journals Biomimetic hydrogels designed for cartilage tissue engineering

2021 ◽  
Author(s):  
Kresanti D. Ngadimin ◽  
Alexander Stokes ◽  
Piergiorgio Gentile ◽  
Ana M. Ferreira
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Polyethylene Glycol ◽  
Chondroitin Sulfate ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Cartilage Tissue

Cartilage-like hydrogels based on materials like gelatin, chondroitin sulfate, hyaluronic acid and polyethylene glycol are reviewed and contrasted, revealing existing limitations and challenges on biomimetic hydrogels for cartilage regeneration.

scholarly journals Fabrication of Injectable Chitosan-Chondroitin Sulfate Hydrogel Embedding Kartogenin-Loaded Microspheres as an Ultrasound-Triggered Drug Delivery System for Cartilage Tissue Engineering

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1487
Author(s):  
Fu-Zhen Yuan ◽  
Hu-Fei Wang ◽  
Jian Guan ◽  
Jiang-Nan Fu ◽  
Meng Yang ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Chondroitin Sulfate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
In Vitro Degradation

Ultrasound-responsive microspheres (MPs) derived from natural polysaccharides and injectable hydrogels have been widely investigated as a biocompatible, biodegradable, and controllable drug delivery system and cell scaffolds for tissue engineering. In this study, kartogenin (KGN) loaded poly (lactide-co-glycolic acid) (PLGA) MPs (MPs@KGN) were fabricated by premix membrane emulsification (PME) method which were sonicated by an ultrasound transducer. Furthermore, carboxymethyl chitosan-oxidized chondroitin sulfate (CMC-OCS) hydrogel were prepared via the Schiff’ base reaction-embedded MPs to produce a CMC-OCS/MPs scaffold. In the current work, morphology, mechanical property, porosity determination, swelling property, in vitro degradation, KGN release from scaffolds, cytotoxicity, and cell bioactivity were investigated. The results showed that MPs presented an obvious collapse after ultrasound treatment. The embedded PLGA MPs could enhance the compressive elastic modulus of soft CMC-OCS hydrogel. The cumulative release KGN from MPs exhibited a slow rate which would display an appropriate collapse after ultrasound, allowing KGN to maintain a continuous concentration for at least 28 days. Moreover, the composite CMC-OCS@MPs scaffolds exhibited faster gelation, lower swelling ratio, and lower in vitro degradation. CCK-8 and LIVE/DEAD staining showed these scaffolds did not influence rabbit bone marrow mesenchymal stem cells (rBMMSCs) proliferation. Then these scaffolds were cultured with rBMMSCs for 2 weeks, and the immunofluorescent staining of collagen II (COL-2) showed that CMC-OCS hydrogel embedded with MPs@KGN (CMC-OCS@MPs@KGN) with ultrasound had the ability to increase the COL-2 synthesis. Overall, due to the improved mechanical property and the ability of sustained KGN release, this injectable hydrogel with ultrasound-responsive property is a promising system for cartilage tissue engineering.

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