scholarly journals Development of a glial cell-derived neurotrophic factor-releasing artificial dura for neural tissue engineering applications

2015 ◽  
Vol 3 (40) ◽  
pp. 7974-7985 ◽  
Author(s):  
N. K. Mohtaram ◽  
J. Ko ◽  
A. Agbay ◽  
D. Rattray ◽  
P. O. Neill ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Glial Cell ◽  
Dura Mater ◽  
Neurotrophic Factor ◽  
Neural Tissue ◽  
Neural Tissue Engineering ◽  
Engineering Applications

Develop a scaffold consisting of aligned, drug releasing nanofiber to serve as a replacement for damaged dura mater.

scholarly journals Electrospun Polyvinylidene Fluoride-Based Fibrous Scaffolds with Piezoelectric Characteristics for Bone and Neural Tissue Engineering

Nanomaterials ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 952 ◽  
Author(s):  
Li ◽  
Liao ◽  
Tjong
Keyword(s):  
Tissue Engineering ◽  
Polyvinylidene Fluoride ◽  
Neural Tissue ◽  
Electrospinning Process ◽  
Neural Cells ◽  
Neural Tissue Engineering ◽  
Engineering Applications ◽  
Pore Sizes ◽  
Β Phase ◽  
Small Pore

Polyvinylidene fluoride (PVDF) and polyvinylidene fluoride-trifluoroethylene (P(VDF-TrFE) with excellent piezoelectricity and good biocompatibility are attractive materials for making functional scaffolds for bone and neural tissue engineering applications. Electrospun PVDF and P(VDF-TrFE) scaffolds can produce electrical charges during mechanical deformation, which can provide necessary stimulation for repairing bone defects and damaged nerve cells. As such, these fibrous mats promote the adhesion, proliferation and differentiation of bone and neural cells on their surfaces. Furthermore, aligned PVDF and P(VDF-TrFE) fibrous mats can enhance neurite growth along the fiber orientation direction. These beneficial effects derive from the formation of electroactive, polar β-phase having piezoelectric properties. Polar β-phase can be induced in the PVDF fibers as a result of the polymer jet stretching and electrical poling during electrospinning. Moreover, the incorporation of TrFE monomer into PVDF can stabilize the β-phase without mechanical stretching or electrical poling. The main drawbacks of electrospinning process for making piezoelectric PVDF-based scaffolds are their small pore sizes and the use of highly toxic organic solvents. The small pore sizes prevent the infiltration of bone and neuronal cells into the scaffolds, leading to the formation of a single cell layer on the scaffold surfaces. Accordingly, modified electrospinning methods such as melt-electrospinning and near-field electrospinning have been explored by the researchers to tackle this issue. This article reviews recent development strategies, achievements and major challenges of electrospun PVDF and P(VDF-TrFE) scaffolds for tissue engineering applications.

scholarly journals Biofabrication for neural tissue engineering applications

2020 ◽  
Vol 6 ◽  
pp. 100043 ◽  
Author(s):  
L. Papadimitriou ◽  
P. Manganas ◽  
A. Ranella ◽  
E. Stratakis
Keyword(s):  
Tissue Engineering ◽  
Neural Tissue ◽  
Neural Tissue Engineering ◽  
Engineering Applications

A facile route to the synthesis of anilinic electroactive colloidal hydrogels for neural tissue engineering applications

2018 ◽  
Vol 516 ◽  
pp. 57-66 ◽  
Author(s):  
Payam Zarrintaj ◽  
Aleksandra M. Urbanska ◽  
Saman Seyed Gholizadeh ◽  
Vahabodin Goodarzi ◽  
Mohammad Reza Saeb ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Neural Tissue ◽  
Neural Tissue Engineering ◽  
Engineering Applications ◽  
Facile Route
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