scholarly journals 3D printing technology to control BMP-2 and VEGF delivery spatially and temporally to promote large-volume bone regeneration

2015 ◽  
Vol 3 (27) ◽  
pp. 5415-5425 ◽  
Author(s):  
Ju Young Park ◽  
Jin-Hyung Shim ◽  
Song-Ah Choi ◽  
Jinah Jang ◽  
Myungshin Kim ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Large Volume ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Engineered Tissue ◽  
Tissue Structures

When large engineered tissue structures are used to achieve tissue regeneration, formation of vasculature is an essential process.

Customized Surgical Protocols for Guided Bone Regeneration Using 3D Printing Technology

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Paloma Manzano Romero ◽  
Valentino Vellone ◽  
Francesco Maffia ◽  
Giuseppe Cicero
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Printing Technology ◽  
3D Printing Technology

scholarly journals Vascularized Bone Regeneration Accelerated by 3D-Printed Nanosilicate-Functionalized Polycaprolactone Scaffold

2021 ◽  
Author(s):  
Xiongcheng Xu ◽  
Long Xiao ◽  
Yanmei Xu ◽  
Jin Zhuo ◽  
Xue Yang ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Bone Repair ◽  
Cytokine Secretion ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed ◽  
Vascularized Bone

Abstract Critical oral-maxillofacial bone defects, damaged by trauma and tumors, not only affect the physiological functions and mental health of patients but are also highly challenging to reconstruct. Personalized biomaterials customized by 3D printing technology have the potential to match oral-maxillofacial bone repair and regeneration requirements. Laponite nanosilicates have been added to biomaterials to achieve biofunctional modification owing to their excellent biocompatibility and bioactivity. Herein, porous nanosilicate-functionalized polycaprolactone (PCL/LAP) was fabricated by 3D printing technology, and its bioactivities in bone regeneration were investigated in vitro and in vivo. In vitro experiments demonstrated that PCL/LAP exhibited good cytocompatibility and enhanced the viability of BMSCs. PCL/LAP functioned to stimulate osteogenic differentiation of BMSCs at the mRNA and protein levels and elevated angiogenic gene expression and cytokine secretion. Moreover, BMSCs cultured on PCL/LAP promoted the angiogenesis potential of endothelial cells by angiogenic cytokine secretion. Then, PCL/LAP scaffolds were implanted into the calvarial defect model. Toxicological safety of PCL/LAP was confirmed, and significant enhancement of vascularized bone formation was observed. Taken together, 3D-printed PCL/LAP scaffolds with brilliant osteogenesis to enhance bone regeneration could be envisaged as an outstanding bone substitute for a promising change in oral-maxillofacial bone defect reconstruction.

scholarly journals 3D Printing Approach in Dentistry: The Future for Personalized Oral Soft Tissue Regeneration

2020 ◽  
Vol 9 (7) ◽  
pp. 2238
Author(s):  
Dobrila Nesic ◽  
Birgit M. Schaefer ◽  
Yue Sun ◽  
Nikola Saulacic ◽  
Irena Sailer
Keyword(s):  
Soft Tissue ◽  
3D Printing ◽  
Tissue Regeneration ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Soft Tissue Regeneration ◽  
Periodontal Tissues ◽  
Surgical Guides ◽  
3D Printed ◽  
Oral Soft Tissue

Three-dimensional (3D) printing technology allows the production of an individualized 3D object based on a material of choice, a specific computer-aided design and precise manufacturing. Developments in digital technology, smart biomaterials and advanced cell culturing, combined with 3D printing, provide promising grounds for patient-tailored treatments. In dentistry, the “digital workflow” comprising intraoral scanning for data acquisition, object design and 3D printing, is already in use for manufacturing of surgical guides, dental models and reconstructions. 3D printing, however, remains un-investigated for oral mucosa/gingiva. This scoping literature review provides an overview of the 3D printing technology and its applications in regenerative medicine to then describe 3D printing in dentistry for the production of surgical guides, educational models and the biological reconstructions of periodontal tissues from laboratory to a clinical case. The biomaterials suitable for oral soft tissues printing are outlined. The current treatments and their limitations for oral soft tissue regeneration are presented, including “off the shelf” products and the blood concentrate (PRF). Finally, tissue engineered gingival equivalents are described as the basis for future 3D-printed oral soft tissue constructs. The existing knowledge exploring different approaches could be applied to produce patient-tailored 3D-printed oral soft tissue graft with an appropriate inner architecture and outer shape, leading to a functional as well as aesthetically satisfying outcome.

scholarly journals Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 341 ◽  
Author(s):  
Xiaoran Li ◽  
Zhenni Chen ◽  
Haimin Zhang ◽  
Yan Zhuang ◽  
He Shen ◽  
...  
Keyword(s):  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Freeze Drying ◽  
Complex Structure ◽  
Biological Processes ◽  
Future Perspectives ◽  
Printing Technology ◽  
3D Printing Technology

Aligned topography and biomolecular gradients exist in various native tissues and play pivotal roles in a set of biological processes. Scaffolds that recapitulate the complex structure and microenvironment show great potential in promoting tissue regeneration and repair. We begin with a discussion on the fabrication of aligned scaffolds, followed by how biomolecular gradients can be immobilized on aligned scaffolds. In particular, we emphasize how electrospinning, freeze drying, and 3D printing technology can accomplish aligned topography and biomolecular gradients flexibly and robustly. We then highlight several applications of aligned scaffolds and biomolecular gradients in regenerative medicine including nerve, tendon/ligament, and tendon/ligament-to-bone insertion regeneration. Finally, we finish with conclusions and future perspectives on the use of aligned scaffolds with biomolecular gradients in regenerative medicine.

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