scholarly journals Conductive and protein resistant polypyrrole films for dexamethasone delivery

2016 ◽  
Vol 4 (15) ◽  
pp. 2570-2577 ◽  
Author(s):  
B. Zhang ◽  
P. J. Molino ◽  
A. R. Harris ◽  
Z. Yue ◽  
S. E. Moulton ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Conducting Polymers ◽  
Protein Adsorption ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Polypyrrole Films ◽  
Significant Interest ◽  
Overall Performance ◽  
Protein Resistant ◽  
The Stability

The development of inherently conducting polymers as controllable/programmable drug delivery systems has attracted significant interest in medical bionics, and the interfacial properties of the polymers, in particular, protein adsorption characteristics, is integral to the stability of the overall performance.

Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

2018 ◽  
Vol 18 (10) ◽  
pp. 857-880 ◽  
Author(s):  
Salma E. Ahmed ◽  
Nahid Awad ◽  
Vinod Paul ◽  
Hesham G. Moussa ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Special Focus ◽  
Nano Drug Delivery ◽  
Medical Researchers ◽  
History Of ◽  
Overall Performance ◽  
Enhanced Stability

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

scholarly journals Polyhydroxyalkanoate Nanoparticles for Pulmonary Drug Delivery: Interaction with Lung Surfactant

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1482
Author(s):  
Olga Cañadas ◽  
Andrea García-García ◽  
M. Auxiliadora Prieto ◽  
Jesús Pérez-Gil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Bacterial Species ◽  
High Surface ◽  
Lung Surfactant ◽  
Delivery Systems ◽  
Pulmonary Drug Delivery ◽  
Epifluorescence Microscopy ◽  
Energy Storage Materials ◽  
The Stability

Polyhydroxyalkanoates (PHA) are polyesters produced intracellularly by many bacterial species as energy storage materials, which are used in biomedical applications, including drug delivery systems, due to their biocompatibility and biodegradability. In this study, we evaluated the potential application of this nanomaterial as a basis of inhaled drug delivery systems. To that end, we assessed the possible interaction between PHA nanoparticles (NPs) and pulmonary surfactant using dynamic light scattering, Langmuir balances, and epifluorescence microscopy. Our results demonstrate that NPs deposited onto preformed monolayers of DPPC or DPPC/POPG bind these surfactant lipids. This interaction facilitated the translocation of the nanomaterial towards the aqueous subphase, with the subsequent loss of lipid from the interface. NPs that remained at the interface associated with liquid expanded (LE)/tilted condensed (TC) phase boundaries, decreasing the size of condensed domains and promoting the intermixing of TC and LE phases at submicroscopic scale. This provided the stability necessary for attaining high surface pressures upon compression, countering the destabilization induced by lipid loss. These effects were observed only for high NP loads, suggesting a limit for the use of these NPs in pulmonary drug delivery.

scholarly journals Bio-orthogonal triazolinedione (TAD) crosslinked protein nanocapsules affect protein adsorption and cell interaction

2020 ◽  
Vol 11 (23) ◽  
pp. 3821-3830 ◽  
Author(s):  
Marie-Luise Frey ◽  
Johanna Simon ◽  
Maximilian Brückner ◽  
Volker Mailänder ◽  
Svenja Morsbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Protein Adsorption ◽  
Drug Delivery Systems ◽  
Cell Interaction ◽  
Delivery Systems ◽  
High Loading ◽  
Loading Capacity ◽  
Low Toxicity

Albumin-based protein nanocarriers obtained by TAD click chemistry have been widely exploited as drug delivery systems, since they show excellent degradability, low toxicity, but at the same time provide high loading capacity and relevant uptake into cells.

scholarly journals Molecular Dynamics Study of Stability and Diffusion of Graphene-Based Drug Delivery Systems

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Xiunan Wang ◽  
Yi Liu ◽  
Jingcheng Xu ◽  
Shengjuan Li ◽  
Fada Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Dynamics ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Graphene Sheets ◽  
Pristine Graphene ◽  
Drug Molecules ◽  
Potential Applications ◽  
The Stability ◽  
And Diffusion

Graphene, a two-dimensional nanomaterial with unique biomedical properties, has attracted great attention due to its potential applications in graphene-based drug delivery systems (DDS). In this work graphene sheets with various sizes and graphene oxide functionalized with polyethylene glycol (GO-PEG) are utilized as nanocarriers to load anticancer drug molecules including CE6, DOX, MTX, and SN38. We carried out molecular dynamics calculations to explore the energetic stabilities and diffusion behaviors of the complex systems with focuses on the effects of the sizes and functionalization of graphene sheets as well as the number and types of drug molecules. Our study shows that the binding of graphene-drug complex is favorable when the drug molecules and finite graphene sheets become comparable in sizes. The boundaries of finite sized graphene sheets restrict the movement of drug molecules. The double-side loading often slows down the diffusion of drug molecules compared with the single-side loading. The drug molecules bind more strongly with GO-PEG than with pristine graphene sheets, demonstrating the advantages of functionalization in improving the stability and biocompatibility of graphene-based DDS.

Plant Extracts Loaded in Nanostructured Drug Delivery Systems for Treating Parasitic and Antimicrobial Diseases

2019 ◽  
Vol 25 (14) ◽  
pp. 1604-1615 ◽  
Author(s):  
Brenna L.C. Gondim ◽  
João A. Oshiro-Júnior ◽  
Felipe H.A. Fernanandes ◽  
Fernanda P. Nóbrega ◽  
Lúcio R.C. Castellano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Plant Extracts ◽  
Drug Delivery Systems ◽  
Biological Activities ◽  
Delivery Systems ◽  
Active Components ◽  
Current Therapies ◽  
The Stability

Background: Plant extracts loaded in nanostructured drug delivery systems (NDDSs) have been reported as an alternative to current therapies for treating parasitic and antimicrobial diseases. Among their advantages, plant extracts in NDSSs increase the stability of the drugs against environmental factors by promoting protection against oxygen, humidity, and light, among other factors; improve the solubility of hydrophobic compounds; enhance the low absorption of the active components of the extracts (i.e., biopharmaceutical classification II), which results in greater bioavailability; and control the release rate of the substances, which is fundamental to improving the therapeutic effectiveness. In this review, we present the most recent data on NDDSs using plant extracts and report results obtained from studies related to in vitro and in vivo biological activities.

scholarly journals Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations

Materials ◽  
2020 ◽  
Vol 13 (2) ◽  
pp. 329 ◽  
Author(s):  
Daria Lovskaya ◽  
Natalia Menshutina
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Amorphous State ◽  
Supercritical Drying ◽  
Delivery Systems ◽  
In Vitro Dissolution ◽  
Supercritical Adsorption ◽  
The Stability ◽  
Active Substances

The present work focuses on the preparation of alginate-based aerogels in the form of particles for their further study as potential drug delivery systems (solid dosage forms). The dripping method was used to prepare certain gel particles, and supercritical drying was used to obtain final alginate-based aerogel particles. Three model active substances (ketoprofen, nimesulide, loratadine) were impregnated into the obtained aerogels using the supercritical adsorption process. Using the method of X-ray analysis, it was shown that the in the obtained drug-loaded aerogels the corresponding active substances are in an amorphous state, and the stability of this state after six months of storage is confirmed. In vitro dissolution tests for obtained drug-loaded aerogels was performed. For each sample, an appropriate dissolution medium (with certain pH) was determined. In vitro investigations showed the increasing of the release rate for all model active substances. Time was required to release and dissolve 50% of the active drug from drug-loaded aerogels (T1/2), reduced in comparison with pure active drugs in crystalline form. Obtained results provide insight into the application of alginate-based aerogel particles as a drug delivery system to improve pharmacokinetic properties of certain active drugs.

Effect of phosphatidylcholine on the stability and lipolysis of nanoemulsion drug delivery systems

2020 ◽  
Vol 583 ◽  
pp. 119354
Author(s):  
Bo Zhang ◽  
Xin Zhou ◽  
Yunqiu Miao ◽  
Xiaoli Wang ◽  
Yuting Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Stability

scholarly journals Drug delivery systems for the photodynamic application of two photosensitizers belonging to the porphyrin family

2021 ◽  
Author(s):  
Miryam Chiara Malacarne ◽  
Stefano Banfi ◽  
Matteo Rugiero ◽  
Enrico Caruso
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tumor Cell Line ◽  
Delivery Systems ◽  
Water Soluble ◽  
Fundamental Aspect ◽  
Tetraphenyl Porphyrin ◽  
Photodynamic Activity ◽  
The Stability ◽  
High Degree

AbstractPhotodynamic therapy involves the concomitant action of three components, light with an appropriate wavelength, molecular oxygen, and a molecule, able to absorb an electromagnetic radiation, called photosensitizer (PS). A fundamental aspect is the bioavailability of the PS that is directly related to some physicochemical properties of the PS itself as it should feature a certain degree of lipophilicity to easily cross the cell membrane, however, at the same time, should be sufficiently water-soluble to navigate in the bloodstream. Consequently, the use of a system for drug delivery becomes essential when photosensitizers with a high degree of lipophilicity are considered. In this work, we present three different drug delivery systems, microemulsions, emulsions and liposomes all capable of carrying a PS belonging to the porphyrin family: the tetraphenyl porphyrin (TPP) and the 4-hydroxyphenyl porphyrin (THPP), which show a relevant different degree of lipophilicity. A series of microemulsions (ME) and emulsions (E) were prepared, among which two formulations, one for THPP and one for TPP, have been chosen. The stability of these two carriers was monitored over time and under various temperature conditions. With the same criteria, two liposomal formulations have been also identified and analyzed. The four formulations mentioned above (one ME, one E and two liposomes) have been tested on SKOV3 tumor cell line comparing the photodynamic activity of the porphyrin formulations versus the aqueous/organic (DMSO) solution of the same two PSs. The results show that all the formulations have proved to be excellent carriers and that the liposomal formulation enhance the photodynamic efficacy of both porphyrins.

Sign in / Sign up

Export Citation Format

Share Document