Ternary graphene quantum dot–polydopamine–Mn3O4nanoparticles for optical imaging guided photodynamic therapy and T1-weighted magnetic resonance imaging

2015 ◽  
Vol 3 (28) ◽  
pp. 5815-5823 ◽  
Author(s):  
Md Nafiujjaman ◽  
Md Nurunnabi ◽  
Sung-hun Kang ◽  
Gerald R. Reeck ◽  
Haseeb A. Khan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Quantum Dot ◽  
Therapeutic Agents ◽  
Oxygen Species ◽  
Resonance Imaging ◽  
Graphene Quantum Dot ◽  
Weighted Magnetic Resonance Imaging ◽  
Dual Imaging

Dual imaging guided therapeutic agents where the Mn3O4cores are combined with graphene quantum dot resulted in significant phototherapeutic effects, apparently by generating toxic reactive oxygen species.

scholarly journals Ultrasensitive magnetic resonance imaging of systemic reactive oxygen species in vivo for early diagnosis of sepsis using activatable nanoprobes

2019 ◽  
Vol 10 (13) ◽  
pp. 3770-3778 ◽  
Author(s):  
Huan Wang ◽  
Dongqin Yu ◽  
Bo Li ◽  
Zhen Liu ◽  
Jinsong Ren ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Reactive Oxygen Species ◽  
Magnetic Resonance ◽  
Early Diagnosis ◽  
Contrast Agents ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Resonance Imaging

Novel ROS-activated contrast agents are designed for magnetic resonance imaging of ROS for early diagnosis of sepsis.

Photo-enhanced antibacterial activity of ZnO/graphene quantum dot nanocomposites

Nanoscale ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 158-166 ◽  
Author(s):  
Junli Liu ◽  
Mauricio D. Rojas-Andrade ◽  
Gustavo Chata ◽  
Yi Peng ◽  
Graham Roseman ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Quantum Dot ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Graphene Quantum Dot ◽  
Room Light ◽  
The Individual

ZnO/GQD nanocomposites exhibit markedly enhanced antimicrobial activity under UV photoirradiation as compared to that in ambient room light, due to photo-induced generation of reactive oxygen species. The activity of the nanocomposite is also higher than that with the individual components.

scholarly journals Reactive Oxygen Species Generation in Human Cells by a Novel Magnetic Resonance Imaging Contrast Agent

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Li Wang ◽  
Eric Lin ◽  
Mary J. Johansen ◽  
Timothy Madden ◽  
Edward Felix ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Reactive Oxygen Species ◽  
Aqueous Solution ◽  
Magnetic Resonance ◽  
Cultured Cells ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Ros Production ◽  
Oxygen Species ◽  
Resonance Imaging

The novel positive-contrast magnetic resonance imaging (MRI) marker C4 consists of an aqueous solution of cobalt chloride (CoCl2) complexed with the chelator N-acetylcysteine (NAC). We evaluated whether the presence of C4 or its components would produce reactive oxygen species (ROS, including hydroxyl, peroxyl, or other reactive oxygen species) in cultured cells. Human cancer or normal cells were incubated with 1% (w/v) CoCl2·6H2O or 2% NAC or a combination of both (1% CoCl2·6H2O : 2% NAC in an aqueous solution, abbreviated as Co : NAC) in the presence or absence of H2O2. Intracellular ROS levels were measured and quantified by change in relative fluorescence units. Student’s t-tests were used. In all cell lines exposed to 1000 μM H2O2, the Co : NAC led to ≥94.7% suppression of ROS at 5 minutes and completely suppressed ROS at 60 and 90 minutes; NAC suppressed ROS by ≥76.6% at 5 minutes and by ≥94.5% at 90 minutes; and CoCl2·6H2O suppressed ROS by ≥37.2% at 30 minutes and by ≥48.6% at 90 minutes. These results demonstrate that neither Co : NAC nor its components generated ROS; rather, they suppressed ROS production in cultured cells, suggesting that C4 would not enhance ROS production in clinical use.

scholarly journals 2D LDH-MoS2 clay nanosheets: synthesis, catalase-mimic capacity, and imaging-guided tumor photo-therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jiayan Zhao ◽  
Hang Wu ◽  
Jiulong Zhao ◽  
Yichen Yin ◽  
Zhilun Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Reactive Oxygen Species ◽  
Colloidal Stability ◽  
Ros Production ◽  
Oxygen Species ◽  
Resonance Imaging ◽  
Promising Candidate ◽  
Anionic Layer ◽  
Catalytic Functions ◽  
Double Hydroxides

AbstractOwing to the hypoxia status of the tumor, the reactive oxygen species (ROS) production during photodynamic therapy (PDT) of the tumor is less efficient. Herein, a facile method which involves the synthesis of Mg–Mn–Al layered double hydroxides (LDH) clay with MoS2 doping in the surface and anionic layer space of LDH was presented, to integrate the photo-thermal effect of MoS2 and imaging and catalytic functions of Mg–Mn–Al LDH. The designed LDH-MoS2 (LMM) clay composite was further surface-coated with bovine serum albumin (BSA) to maintain the colloidal stability of LMM in physiological environment. A photosensitizer, chlorin e6 (Ce6), was absorbed at the surface and anionic layer space of LMM@BSA. In the LMM formulation, the magnetic resonance imaging of Mg–Mn–Al LDH was enhanced thanks to the reduced and acid microenvironment of the tumor. Notably, the ROS production and PDT efficiency of Ce6 were significantly improved, because LMM@BSA could catalyze the decomposing of the overexpressed H2O2 in tumors to produce oxygen. The biocompatible LMM@BSA that played the synergism with tumor microenvironment is a promising candidate for the effective treatment of cancer.

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