scholarly journals Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery

2015 ◽  
Vol 3 (25) ◽  
pp. 5005-5009 ◽  
Author(s):  
John G. Hardy ◽  
Megan N. Amend ◽  
Sydney Geissler ◽  
Vincent M. Lynch ◽  
Christine E. Schmidt
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Directed Assembly ◽  
Supramolecular Polymers ◽  
Tongue Twisters

We report the preparation and characterization of films of electroactive supramolecular polymers based on non-electroactive oligoalanines and electroactive oligoanilines.

scholarly journals Synthesis and characterization of novel protein nanodots as drug delivery carriers with an enhanced biological efficacy of melatonin in breast cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9076-9085
Author(s):  
Kanchan Yadav ◽  
Megha Das ◽  
Nurul Hassan ◽  
Archana Mishra ◽  
Jayeeta Lahiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Live Cell Imaging ◽  
Biomedical Applications ◽  
Breast Cancer Cells ◽  
Cell Imaging ◽  
Synthesis And Characterization ◽  
Novel Protein

A novel nanodot-using protein has been synthesized for the live cell imaging and drug delivery of melatonin in breast cancer cells. Its unique properties hold potential for various biomedical applications in the field of bioimaging and drug delivery.

A poloxamer-polypeptide thermosensitive hydrogel as a cell scaffold and sustained release depot

2016 ◽  
Vol 7 (17) ◽  
pp. 2976-2985 ◽  
Author(s):  
Ji-Yu Lin ◽  
Po-Liang Lai ◽  
Yuan-Kai Lin ◽  
Sydney Peng ◽  
Li-Yu Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Sustained Release ◽  
Biomedical Applications ◽  
Synthesis And Characterization ◽  
Thermosensitive Hydrogel ◽  
Cell Scaffold ◽  
A Cell ◽  
Positively Charged

Herein, we report the synthesis and characterization of a novel positively charged thermosensitive hydrogel prepared from poloxamer (PLX)-poly(l-alanine-lysine) (Lys-Ala-PLX-Ala-Lys) that demonstrates potential in biomedical applications including tissue engineering and drug delivery.

Biodegradable polycaprolactone (PCL) based polymer and composites

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Emily Archer ◽  
Marissa Torretti ◽  
Samy Madbouly
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Ring Opening ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Food Packaging ◽  
Delivery Systems ◽  
Implantable Devices

Abstract Polycaprolactone (PCL) is a biodegradable polyester that has advantages over other biopolymers, making it an extensively researched polymer. PCL is a hydrophobic, slow-degrading, synthetic polymer making it particularly interesting for the preparation of long-term implantable devices and a variety of drug delivery systems. Recently, PCL has been used for additional applications including food packaging and tissue engineering. In this chapter, the processing methods and characterization of PCL will be discussed. The chapter will summarize the synthesis of poly(α-hydroxy acid) and the ring-opening polymerization of PCL. Discussion on the biodegradability of PCL will be reviewed. The biomedical applications of PCL, such as, drug-delivery systems, medical devices, and tissue engineering will be also summarized. Finally, the chapter will conclude with a characterization section outlining recent studies focusing on PCL based composites and films.

scholarly journals Characterization of Commercial PLGAs by NMR Spectroscopy

2021 ◽  
Author(s):  
Jing Sun ◽  
Jennifer Walker ◽  
Moritz Beck-Broichsitter ◽  
Steve Schwendeman
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Nmr Spectroscopy ◽  
Biomedical Applications ◽  
Glycolic Acid ◽  
Factors Affecting ◽  
Hydrolytic Process ◽  
End Capping ◽  
G Ratio

Abstract Poly(lactic- co -glycolic acid) (PLGA) is among the most common of biodegradable polymers studied in various biomedical applications such as drug delivery and tissue engineering. To facilitate the understanding of the often overlooked PLGA microstructure on important factors affecting PLGA performance, we measured four key parameters of 17 commonly used commercial PLGA polymers (Resomer ®, Expansorb ®, Purasorb ®, Lactel ®, and Wako ® ) by NMR spectroscopy. 1 HNMR and 13 CNMR spectra were used to determine lactic to glycolic ratio (L/G ratio), polymer end-capping, glycolic blockiness ( Rc ), and average glycolic and lactic block lengths ( L G and L L ). In PLGAs with a labeled L/G ratio of 50/50 and acid end capping, the actual lactic content slightly decreased as molecular weight increased in both Resomer ® and Expansorb ®. Whether or not acid- or ester-, termination of these PLGAs was confirmed to be consistent with their brand labels. Moreover, in the ester end-capped 75/25 L/G ratio group, the blockiness value ( Rc ) of Resomer ® RG 756S ( Rc : 1.7) was highest in its group; whereas for the 50/50 acid end-capped group, Expansorb ® DLG 50-2A ( Rc : 1.9) displayed notably higher values than their counterparts. Resomer ® RG 502 ( L L : 2.6, L G : 2.5) and Expansorb ® DLG 50-2E ( L L : 2.5, L G : 2.6) showed the lowest block lengths, suggesting they may undergo a steadier hydrolytic process compared to random, heterogeneously distributed PLGA.

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