Integrated 3D conducting polymer-based bioelectronics for capture and release of circulating tumor cells

2015 ◽  
Vol 3 (25) ◽  
pp. 5103-5110 ◽  
Author(s):  
Yu-Sheng Hsiao ◽  
Bo-Cheng Ho ◽  
Hong-Xin Yan ◽  
Chiung-Wen Kuo ◽  
Di-Yen Chueh ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Conducting Polymer ◽  
Circulating Tumor Cell ◽  
Cell Capture ◽  
Capture And Release

3D conducting polymer-based bioelectronic interface (BEI) devices for dynamically controlling circulating tumor cell capture/release performance through the cyclic potential of electrical stimulation.

Circulating tumor cell detection using a parallel flow micro-aperture chip system

Lab on a Chip ◽  
2015 ◽  
Vol 15 (7) ◽  
pp. 1677-1688 ◽  
Author(s):  
Chun-Li Chang ◽  
Wanfeng Huang ◽  
Shadia I. Jalal ◽  
Bin-Da Chan ◽  
Aamer Mahmood ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Circulating Tumor Cell ◽  
Parallel Flow ◽  
Cell Detection ◽  
Tumor Cell Detection ◽  
System P

A parallel flow micro-aperture chip system for detection of circulating tumor cells.

scholarly journals Microfluidics-enabled rapid manufacturing of hierarchical silica-magnetic microflower toward enhanced circulating tumor cell screening

2018 ◽  
Vol 6 (12) ◽  
pp. 3121-3125 ◽  
Author(s):  
Nanjing Hao ◽  
Yuan Nie ◽  
Amogha Tadimety ◽  
Ting Shen ◽  
John X. J. Zhang
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Circulating Tumor Cell ◽  
Rapid Manufacturing ◽  
Screening Efficiency

Microfluidics-enabled rapid manufacturing of a hierarchical silica-magnetic microflower was developed for improving the screening efficiency of circulating tumor cells.

scholarly journals Precision microfilters as an all in one system for multiplex analysis of circulating tumor cells

RSC Advances ◽  
2016 ◽  
Vol 6 (8) ◽  
pp. 6405-6414 ◽  
Author(s):  
Daniel L. Adams ◽  
R. Katherine Alpaugh ◽  
Stuart S. Martin ◽  
Monica Charpentier ◽  
Saranya Chumsri ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Circulating Tumor Cell ◽  
Clinical Testing ◽  
Multiplex Analysis

An all-in-one Circulating Tumor Cell (CTC) isolation platform with streamlined multiplex integration of proteomic and genomic clinical testing.

scholarly journals Modification of Hemodialysis Membranes for Efficient Circulating Tumor Cell Capture for Cancer Therapy

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4845
Author(s):  
Gabor Jarvas ◽  
Dora Szerenyi ◽  
Jozsef Tovari ◽  
Laszlo Takacs ◽  
Andras Guttman
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Metabolism ◽  
Cell Types ◽  
Circulating Tumor Cell ◽  
Blood Stream ◽  
Normal Function ◽  
Cell Capture ◽  
Buffer Solution ◽  
Cell Clearance

Background: It is well known that more than 90% of cancer deaths are due to metastases. However, the entire tumorigenesis process is not fully understood, and it is evident that cells spreading from the primary tumor play a key role in initiating the metastatic process. Tumor proliferation and invasion also elevate the concentration of regular and irregular metabolites in the serum, which may alter the normal function of the entire human homeostasis and possibly causes cancer metabolism syndrome, also referred to as cachexia. Methods: We report on the modification of commercially available hemodialysis membranes to selectively capture circulating tumor cells from the blood stream by means of immobilized human anti-EpCAM antibodies on the inner surface of the fibers. All critical steps are described that required in situ addition of the immuno-affinity feature to hemodialyzer cartridges in order to capture EpCAM positive circulating tumor cells, which represents ~80% of cancer cell types. Results: The cell capture efficiency of the suggested technology was demonstrated by spiking HCT116 cancer cells both into buffer solution and whole blood and run through on the modified cartridge. Flow cytometry was used to quantitatively evaluate the cell clearance performance of the approach. Conclusions: The suggested modification has no significant effect on the porous structure of the hemodialysis membranes; it keeps its cytokine removal capability, addressing cachexia simultaneously with CTC removal.

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