scholarly journals The role of solvent swelling in the self-assembly of squalene based nanomedicines

Soft Matter ◽  
2015 ◽  
Vol 11 (21) ◽  
pp. 4173-4179 ◽  
Author(s):  
Debasish Saha ◽  
Fabienne Testard ◽  
Isabelle Grillo ◽  
Fatima Zouhiri ◽  
Didier Desmaele ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Role Of Solvent ◽  
Solvent Swelling

Squalene based nanoparticles obtained via nanoprecipitation are promising candidates as efficient anti-cancer drugs.

The Role of Solvent Additive on Polymer Crystallinity During Physical Supercritical Fluid Deposition

2021 ◽  
Author(s):  
Nastaran Yousefi ◽  
Richard Pettipas ◽  
Behrad Saeedi Saghez ◽  
Timothy L. Kelly ◽  
Loren G. Kaake
Keyword(s):  
Thin Films ◽  
Supercritical Fluid ◽  
Supercritical Fluids ◽  
Self Assembly ◽  
The Self ◽  
Deposition Technique ◽  
Solvent Additive ◽  
Polymer Crystallinity ◽  
Role Of Solvent

We investigated the self-assembly of polymers in supercritical fluids by depositing thin films of isotactic polypropylene from n-pentane:acetone solutions and studying their structure. The deposition technique leverages a maximum in...

Directive Effect of Chain Length in Modulating Peptide Nano-assemblies

2020 ◽  
Vol 27 (9) ◽  
pp. 923-929
Author(s):  
Gaurav Pandey ◽  
Prem Prakash Das ◽  
Vibin Ramakrishnan
Keyword(s):  
Electron Microscopy ◽  
Amino Acids ◽  
Light Scattering ◽  
Chain Length ◽  
Self Assembly ◽  
The Self ◽  
Ionic Charge ◽  
Self Assembling ◽  
Biophysical Techniques

Background: RADA-4 (Ac-RADARADARADARADA-NH2) is the most extensively studied and marketed self-assembling peptide, forming hydrogel, used to create defined threedimensional microenvironments for cell culture applications. Objectives: In this work, we use various biophysical techniques to investigate the length dependency of RADA aggregation and assembly. Methods: We synthesized a series of RADA-N peptides, N ranging from 1 to 4, resulting in four peptides having 4, 8, 12, and 16 amino acids in their sequence. Through a combination of various biophysical methods including thioflavin T fluorescence assay, static right angle light scattering assay, Dynamic Light Scattering (DLS), electron microscopy, CD, and IR spectroscopy, we have examined the role of chain-length on the self-assembly of RADA peptide. Results: Our observations show that the aggregation of ionic, charge-complementary RADA motifcontaining peptides is length-dependent, with N less than 3 are not forming spontaneous selfassemblies. Conclusion: The six biophysical experiments discussed in this paper validate the significance of chain-length on the epitaxial growth of RADA peptide self-assembly.

scholarly journals Understanding the role of conjugation length on the self-assembly behaviour of oligophenyleneethynylenes

2021 ◽  
Author(s):  
Beatriz Matarranz ◽  
Goutam Ghosh ◽  
Ramesh Kandanelli ◽  
Angel Sampedro ◽  
Kalathil K. Kartha ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Conjugation Length ◽  
The Relationship

We unravel the relationship between conjugation length and self-assembly behaviour of oligophenyleneethynylenes (OPEs).

Role of protein S-Glutathionylation in cancer progression and development of resistance to anti-cancer drugs

2021 ◽  
Vol 704 ◽  
pp. 108890
Author(s):  
Debojyoti Pal ◽  
Archita Rai ◽  
Rahul Checker ◽  
R.S. Patwardhan ◽  
Babita Singh ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Protein S ◽  
Cancer Drugs ◽  
Development Of Resistance ◽  
Anti Cancer

Role of Multivalent Cations in the Self-Assembly of Phospholipid−DNA Complexes

2007 ◽  
Vol 111 (51) ◽  
pp. 14233-14238 ◽  
Author(s):  
Guillaume Tresset ◽  
Wun Chet Davy Cheong ◽  
Yeng Ming Lam
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Dna Complexes

scholarly journals Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance

2018 ◽  
Vol 20 (1) ◽  
pp. 51 ◽  
Author(s):  
Yoojung Kwon ◽  
Youngmi Kim ◽  
Hyun Jung ◽  
Dooil Jeoung
Keyword(s):  
Molecular Networks ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
Angiogenic Potential ◽  
Histone Deacetylase 3 ◽  
Cancer Drug Resistance ◽  
Tumorigenic Potential ◽  
Anti Cancer ◽  
Cancer Testis

Histone modification is associated with resistance to anti-cancer drugs. Epigenetic modifications of histones can regulate resistance to anti-cancer drugs. It has been reported that histone deacetylase 3 (HDAC3) regulates responses to anti-cancer drugs, angiogenic potential, and tumorigenic potential of cancer cells in association with cancer-associated genes (CAGE), and in particular, a cancer/testis antigen gene. In this paper, we report the roles of microRNAs that regulate the expression of HDAC3 and CAGE involved in resistance to anti-cancer drugs and associated mechanisms. In this review, roles of HDAC3-miRNAs-CAGE molecular networks in resistance to anti-cancer drugs, and the relevance of HDAC3 as a target for developing anti-cancer drugs are discussed.

Self-Assembly of Alkali Lignin in Tetrahydrofuran

2012 ◽  
Vol 550-553 ◽  
pp. 57-61
Author(s):  
Hao Li ◽  
Yong Hong Deng ◽  
Kai Huang
Keyword(s):  
Charge Transfer ◽  
Electrostatic Interaction ◽  
Self Assembly ◽  
The Self ◽  
Charge Transfer Complexes ◽  
Layer By Layer ◽  
Alkali Lignin ◽  
Higher Temperature ◽  
Effects Of Temperature

Alkali lignin (AL) was used as a polyanion to form layer-by-layer self-assembled film with PDAC as a polycation. The effects of temperature and concentration on the adsorption characteristics of AL were investigated. Iodine was added into AL solutions to study the role of π-π interaction in self-assembly of AL and PDAC. Results show that the self-assembly of AL/PDAC is mainly driven by π-π interaction and electrostatic interaction. A higher temperature or a larger concentration can enhance the aggregation of lignin. I2 can form lignin–iodine charge–transfer complexes with AL to reduce the degree of aggregation of AL, so the adsorbed amount of AL decreases significantly with increasing iodine contents.

On the Role of Chirality in Guiding the Self-Assembly of Peptides

2017 ◽  
Vol 129 (43) ◽  
pp. 13473-13477 ◽  
Author(s):  
Shibaji Basak ◽  
Ishwar Singh ◽  
Annaleizle Ferranco ◽  
Jebreil Syed ◽  
Heinz-Bernhard Kraatz
Keyword(s):  
Self Assembly ◽  
The Self

Nuclear delivery of dual anti-cancer drugs by molecular self-assembly

2021 ◽  
Vol 9 (1) ◽  
pp. 116-123
Author(s):  
Jindao Wu ◽  
Wenzhou Ding ◽  
Guoyong Han ◽  
Wei You ◽  
Wen Gao ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Tumor Cells ◽  
Self Assembly ◽  
Nuclear Accumulation ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Good Cell

Nanomedicines generally suffer from poor accumulation in tumor cells, low anti-tumor efficacy, and drug resistance. In order to address these problems, we introduced a novel nanomedicine based on dual anti-cancer drugs, which showed good cell nuclear accumulation properties.

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