scholarly journals Parallel folding topology-selective label-free detection and monitoring of conformational and topological changes of different G-quadruplex DNAs by emission spectral changes via FRET of mPPE-Ala–Pt(ii) complex ensemble

2016 ◽  
Vol 7 (4) ◽  
pp. 2842-2855 ◽  
Author(s):  
Kevin Chan ◽  
Clive Yik-Sham Chung ◽  
Vivian Wing-Wah Yam
Keyword(s):  
Label Free ◽  
Spectral Changes ◽  
Label Free Detection ◽  
G Quadruplex ◽  
Topological Transitions ◽  
Parallel Folding ◽  
Selective Label ◽  
Topological Changes

The ensemble of platinum(ii) complex andmPPE-Ala has been demonstrated for label-free detection of G-quadruplex DNAs and the probing of their topological transitions.

scholarly journals Comparison of DNAzyme activity for the development of an immobilized heme sensor

MRS Advances ◽  
2018 ◽  
Vol 3 (26) ◽  
pp. 1491-1496
Author(s):  
Natalie Hughes ◽  
Nancy Nguyen ◽  
Deanna-Kaye Daley ◽  
Justin Grennell ◽  
Amira Gee ◽  
...  
Keyword(s):  
Self Assembly ◽  
Point Of Care ◽  
Label Free ◽  
Detection Range ◽  
Chemical Complexity ◽  
Detection Strategy ◽  
Detection Approach ◽  
Label Free Detection ◽  
G Quadruplex ◽  
Care Systems

ABSTRACTPoint-of-care systems require highly sensitive, quantitative and selective detection platforms for the real-time multiplexed monitoring of target analytes. To ensure facile development of a sensor, it is preferable for the detection assay to have minimal chemical complexity, contain no wash steps and provide a wide and easily adaptable detection range for multiple targets. Current studies involve label-free detection strategy for relevant clinical molecules such as heme using G-quadruplex based self-assembly. We have explored the measurement of binding and kinetic parameters of various G-quadruplex/heme complexes which are able to self-associate to form a DNAzyme with peroxidase mimicking capabilities and are critical to nucleic acid research. The detection strategy includes immobilizing the G-quadruplex sequences within a polymer matrix to provide a self-assembly based detection approach for heme that could be translated towards other clinically relevant targets.

scholarly journals Label Free Detection of Adenosine Based on Hemin/G-Quadruplex Peroxidase-Mimicking DNAzyme as Bioelectrocatalyst

2013 ◽  
Vol 25 (18) ◽  
pp. 10541-10545 ◽  
Author(s):  
Yu Li ◽  
Sen Li ◽  
Ge-Qing Xia ◽  
Yuansheng Wang
Keyword(s):  
Label Free ◽  
Label Free Detection ◽  
G Quadruplex

Cationic-perylene-G-quadruplex complex based fluorescent biosensor for label-free detection of Pb 2+

Talanta ◽  
2016 ◽  
Vol 149 ◽  
pp. 98-102 ◽  
Author(s):  
Xu-Hua Zhao ◽  
Liang Gong ◽  
Yuan Wu ◽  
Xiao-Bing Zhang ◽  
Jun Xie
Keyword(s):  
Label Free ◽  
Fluorescent Biosensor ◽  
Label Free Detection ◽  
G Quadruplex

scholarly journals Label-free Detection of Zn2+ Based on G-quadruplex

2015 ◽  
Vol 31 (10) ◽  
pp. 1041-1045 ◽  
Author(s):  
Yahui GUO ◽  
Yan SUN ◽  
Xiaoqiang SHEN ◽  
Kunchi ZHANG ◽  
Jiming HU ◽  
...  
Keyword(s):  
Label Free ◽  
Label Free Detection ◽  
G Quadruplex

Enzyme-Activated G-Quadruplex Synthesis for in Situ Label-Free Detection and Bioimaging of Cell Apoptosis

2017 ◽  
Vol 89 (3) ◽  
pp. 1892-1899 ◽  
Author(s):  
Zhuoliang Liu ◽  
Xingyu Luo ◽  
Zhu Li ◽  
Yan Huang ◽  
Zhou Nie ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Label Free ◽  
Label Free Detection ◽  
G Quadruplex
Sign in / Sign up

Export Citation Format

Share Document