scholarly journals An ultrasensitive near-infrared ratiometric fluorescent probe for imaging mitochondrial polarity in live cells and in vivo

2016 ◽  
Vol 7 (2) ◽  
pp. 1588-1593 ◽  
Author(s):  
Haibin Xiao ◽  
Ping Li ◽  
Wei Zhang ◽  
Bo Tang
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Live Cells ◽  
Mitochondria Targeting ◽  
Ratiometric Fluorescent Probe

We describe a new mitochondria-targeting fluorescent probeMCY-BF2that is singularly sensitive and specifically responsive to mitochondrial polarity.

scholarly journals A Fast-Response Red Shifted Fluorescent Probe for Detection of H2S in Living Cells

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 437 ◽  
Author(s):  
Ismail Ismail ◽  
Zhuoyue Chen ◽  
Xiuru Ji ◽  
Lu Sun ◽  
Long Yi ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Redox Homeostasis ◽  
Fast Response ◽  
Living Cells ◽  
Live Cells ◽  
Minimal Damage ◽  
Auto Fluorescence ◽  
Mitochondria Targeting

Near-infrared (NIR) fluorescent probes are attractive tools for bioimaging applications because of their low auto-fluorescence interference, minimal damage to living samples, and deep tissue penetration. H2S is a gaseous signaling molecule that is involved in redox homeostasis and numerous biological processes in vivo. To this end, we have developed a new red shifted fluorescent probe 1 to detect physiological H2S in live cells. The probe 1 is based on a rhodamine derivative as the red shifted fluorophore and the thiolysis of 7-nitro 1,2,3-benzoxadiazole (NBD) amine as the H2S receptor. The probe 1 displays fast fluorescent enhancement at 660 nm (about 10-fold turn-ons, k2 = 29.8 M−1s−1) after reacting with H2S in buffer (pH 7.4), and the fluorescence quantum yield of the activated red shifted product can reach 0.29. The probe 1 also exhibits high selectivity and sensitivity towards H2S. Moreover, 1 is cell-membrane-permeable and mitochondria-targeting, and can be used for imaging of endogenous H2S in living cells. We believe that this red shifted fluorescent probe can be a useful tool for studies of H2S biology.

High-Quantum-Yield Mitochondria-Targeting Near-Infrared Fluorescent Probe for Imaging Native Hypobromous Acid in Living Cells and in Vivo

2017 ◽  
Vol 89 (3) ◽  
pp. 1787-1792 ◽  
Author(s):  
Xiaojun Liu ◽  
Aishan Zheng ◽  
Dongrui Luan ◽  
Xiaoting Wang ◽  
Fanpeng Kong ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
High Quantum Yield ◽  
High Quantum ◽  
Hypobromous Acid ◽  
Mitochondria Targeting

A ratiometric mitochondria-targeting two-photon fluorescent probe for imaging of nitric oxide in vivo

The Analyst ◽  
2017 ◽  
Vol 142 (24) ◽  
pp. 4623-4628 ◽  
Author(s):  
Xinyue Zhu ◽  
Jin-Quan Chen ◽  
Chen Ma ◽  
Xiaoyan Liu ◽  
Xiao-Ping Cao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Fluorescent Probe ◽  
Two Photon ◽  
Mitochondria Targeting ◽  
Ratiometric Fluorescent Probe

A two-photon ratiometric fluorescent probe (Mito-N) has been developed for monitoring mitochondrial nitric oxide (NO) in vivo.

A near-infrared multifunctional fluorescent probe with an inherent tumor-targeting property for bioimaging

2015 ◽  
Vol 51 (58) ◽  
pp. 11721-11724 ◽  
Author(s):  
Xu Zhao ◽  
Yang Li ◽  
Di Jin ◽  
Yuzhi Xing ◽  
Xilong Yan ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Mitochondria Targeting

A mitochondria-targeting near-infrared switchable probe for in vitro and in vivo tumor-targeting imaging.

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