A near-infrared multifunctional fluorescent probe with an inherent tumor-targeting property for bioimaging

2015 ◽  
Vol 51 (58) ◽  
pp. 11721-11724 ◽  
Author(s):  
Xu Zhao ◽  
Yang Li ◽  
Di Jin ◽  
Yuzhi Xing ◽  
Xilong Yan ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Mitochondria Targeting

A mitochondria-targeting near-infrared switchable probe for in vitro and in vivo tumor-targeting imaging.

A novel colorimetric and near-infrared fluorescent probe for hydrogen peroxide imaging in vitro and in vivo

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85957-85963 ◽  
Author(s):  
Peng Wang ◽  
Ke Wang ◽  
Dan Chen ◽  
Yibo Mao ◽  
Yueqing Gu
Keyword(s):  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Near Infrared

A novel NIR fluorescent probe (DCM-B2) based on dicyanomethylene-4H-pyran was synthesized for the detection of H2O2.

High-Quantum-Yield Mitochondria-Targeting Near-Infrared Fluorescent Probe for Imaging Native Hypobromous Acid in Living Cells and in Vivo

2017 ◽  
Vol 89 (3) ◽  
pp. 1787-1792 ◽  
Author(s):  
Xiaojun Liu ◽  
Aishan Zheng ◽  
Dongrui Luan ◽  
Xiaoting Wang ◽  
Fanpeng Kong ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
High Quantum Yield ◽  
High Quantum ◽  
Hypobromous Acid ◽  
Mitochondria Targeting

A NIR fluorescent probe for the detection of fluoride ions and its application in in vivo bioimaging

2017 ◽  
Vol 5 (10) ◽  
pp. 2002-2009 ◽  
Author(s):  
Qiuyun Yang ◽  
Chunman Jia ◽  
Qing Chen ◽  
Wei Du ◽  
Yile Wang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Fluoride Ions

A near-infrared fluorescent probe has been developed, which is available for visualizing exogenous fluoride ions in vitro and in vivo.

A novel near-infrared xanthene-based fluorescent probe for detection of thiophenol in vitro and in vivo

2020 ◽  
Vol 44 (40) ◽  
pp. 17360-17367
Author(s):  
Yongquan Wu ◽  
Aiping Shi ◽  
Huiying Liu ◽  
Yuanyan Li ◽  
Weican Lun ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells

A novel near-infrared xanthene-based fluorescent probe for detection of thiophenol in living cells and mice.

An RGD modified water-soluble fluorophore probe for in vivo NIR-II imaging of thrombosis

2020 ◽  
Vol 8 (16) ◽  
pp. 4438-4446
Author(s):  
Yanping Wu ◽  
Chao Wang ◽  
Jiaqi Guo ◽  
Abdlay Carvalho ◽  
Yuyu Yao ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Water Soluble

Synthesis of an organic near-infrared second-window fluorescent probe targeting in vivo and in vitro thrombi.

scholarly journals Identification of a mitochondria-targeting fluorescent small molecule for dual phototherapy

2018 ◽  
Vol 11 (04) ◽  
pp. 1850016 ◽  
Author(s):  
Jie Chen ◽  
Xu Tan ◽  
Shenglin Luo ◽  
Lei Long ◽  
Lang Liu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Near Infrared ◽  
Significant Inhibition ◽  
Cytotoxicity Studies ◽  
Inhibition Of Tumor Growth ◽  
High Cytotoxicity ◽  
Mitochondria Targeting

Phototherapy, mainly including photodynamic therapy (PDT) and photothermal therapy (PTT), is a noninvasive and effective approach for cancer treatment. Since integration of PDT and PTT for simultaneous synergistic PDT/PTT treatment enables us to improve phototherapeutic efficacy significantly, it has been attracting a lot of investigations in current days. Here, we introduce IR-52, a new mitochondria-targeting near infrared (NIR) fluorescent small molecule, which possesses structure-inherent PTT and PDT synergistic phototherapeutic effects without conjugation to specific ligands. After NIR light irradiation (808[Formula: see text]nm, 2[Formula: see text]W/cm2, 5[Formula: see text]min), both the hyperthermia and excessive singlet oxygen levels were determined when dissolving IR-52 in aqueous solutions. In vitro photoinduced cytotoxicity studies showed significant lower cell viabilities and higher necrotic/apoptotic rates when cancer cells were treated with IR-52 and irradiation, and its’ mitochondrial localization in cancer cells would partially explain its high cytotoxicity. Further in vivo synergetic PDT and PTT effects were demonstrated by high tumor surface temperature and significant inhibition of tumor growth. Our results strongly suggest that IR-52, which possesses excellent photosensitivity, may provide a promising strategy for tumor treatment with decreased side effects.

Near-Infrared Fluorescent Probe Activated by Nitroreductase for In Vitro and In Vivo Hypoxic Tumor Detection

2021 ◽  
Author(s):  
Sanu Karan ◽  
Mi Young Cho ◽  
Hyunseung Lee ◽  
Hwunjae Lee ◽  
Hye Sun Park ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Tumor Detection ◽  
Hypoxic Tumor

A novel fibroblast activation protein-targeted near-infrared fluorescent off–on probe for cancer cell detection, in vitro and in vivo imaging

2018 ◽  
Vol 6 (10) ◽  
pp. 1449-1451 ◽  
Author(s):  
Jie Xing ◽  
Qiuyu Gong ◽  
Ruifen Zou ◽  
Zihou Li ◽  
Yuanzhi Xia ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Fibroblast Activation Protein ◽  
Cell Detection ◽  
Fibroblast Activation ◽  
Design And Synthesis ◽  
Cancer Cell Detection

Design and synthesis of a novel fibroblast activation protein “off–on” near-infrared fluorescent probe for cell detection, in vitro and in vivo imaging.

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