scholarly journals A unique approach toward near-infrared fluorescent probes for bioimaging with remarkably enhanced contrast

2016 ◽  
Vol 7 (3) ◽  
pp. 2275-2285 ◽  
Author(s):  
Yi-Jun Gong ◽  
Xiao-Bing Zhang ◽  
Guo-Jiang Mao ◽  
Li Su ◽  
Hong-Min Meng ◽  
...  

A universal sensing platform with significantly enhanced image contrast and apparent brightness in biological imaging applications.

CrystEngComm ◽  
2014 ◽  
Vol 16 (41) ◽  
pp. 9622-9630 ◽  
Author(s):  
Liping Ding ◽  
Shulian He ◽  
Dechao Chen ◽  
Mei Huang ◽  
Jinzhang Xu ◽  
...  

Quantum dot composites (PS@Cd3P2, SiO2@Cd3P2) were prepared and employed for the first time as fluorescent probes for biological imaging.


2020 ◽  
Vol 8 (35) ◽  
pp. 7856-7879
Author(s):  
Fan Yang ◽  
Qingzhe Zhang ◽  
Shengyun Huang ◽  
Dongling Ma

Near infrared (NIR)-excitable and NIR-emitting probes have fuelled advances in biomedical applications owing to their power in enabling deep tissue imaging, offering high image contrast and reducing phototoxicity.


2016 ◽  
Vol 7 (3) ◽  
pp. 1896-1903 ◽  
Author(s):  
Hua Chen ◽  
Yonghe Tang ◽  
Mingguang Ren ◽  
Weiying Lin

We describe a unique approach for the development of an interesting type of the fluorescent probes, which can show different modes of fluorescence signals to distinct concentration ranges of a target of interest.


2021 ◽  
Vol 8 (8) ◽  
pp. 1867-1889
Author(s):  
Zhiming Xing ◽  
Wanhui Wu ◽  
Yongxiang Miao ◽  
Yingqun Tang ◽  
Youkang Zhou ◽  
...  

This review summarized recent advances relating to the luminescence properties of quinazolinones and their applications in fluorescent probes, biological imaging and luminescent materials. Their future outlook is also included.


2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Anna Kanegae ◽  
Yusuke Takata ◽  
Ippei Takashima ◽  
Shohei Uchinomiya ◽  
Ryosuke Kawagoe ◽  
...  

AbstractDespite continuous and active development of fluorescent metal-ion probes, their molecular design for ratiometric detection is restricted by the limited choice of available sensing mechanisms. Here we present a multicolor and ratiometric fluorescent sensing platform for metal ions based on the interaction between the metal ion and the aromatic ring of a fluorophore (arene–metal-ion, AM, coordination). Our molecular design provided the probes possessing a 1,9-bis(2′-pyridyl)-2,5,8-triazanonane as a flexible metal ion binding unit attached to a tricyclic fluorophore. This architecture allows to sense various metal ions, such as Zn(II), Cu(II), Cd(II), Ag(I), and Hg(II) with emission red-shifts. We showed that this probe design is applicable to a series of tricyclic fluorophores, which allow ratiometric detection of the metal ions from the blue to the near-infrared wavelengths. X-ray crystallography and theoretical calculations indicate that the coordinated metal ion has van der Waals contact with the fluorophore, perturbing the dye’s electronic structure and ring conformation to induce the emission red-shift. A set of the probes was useful for the differential sensing of eight metal ions in a one-pot single titration via principal component analysis. We also demonstrate that a xanthene fluorophore is applicable to the ratiometric imaging of metal ions under live-cell conditions.


2020 ◽  
Vol 39 (1) ◽  
pp. 209-221
Author(s):  
Jiafeng Wan ◽  
Xiaoyuan Zhang ◽  
Kai Zhang ◽  
Zhiqiang Su

Abstract In recent years, nanomaterials have attracted lots of attention from researchers due to their unique properties. Nanometer fluorescent materials, such as organic dyes, semiconductor quantum dots (QDs), metal nano-clusters (MNCs), carbon dots (CDs), etc., are widely used in biological imaging due to their high sensitivity, short response time, and excellent accuracy. Nanometer fluorescent probes can not only perform in vitro imaging of organisms but also achieve in vivo imaging. This provides medical staff with great convenience in cancer treatment. Combined with contemporary medical methods, faster and more effective treatment of cancer is achievable. This article explains the response mechanism of three-nanometer fluorescent probes: the principle of induced electron transfer (PET), the principle of fluorescence resonance energy transfer (FRET), and the principle of intramolecular charge transfer (ICT), showing the semiconductor QDs, precious MNCs, and CDs. The excellent performance of the three kinds of nano fluorescent materials in biological imaging is highlighted, and the application of these three kinds of nano fluorescent probes in targeted biological imaging is also introduced. Nanometer fluorescent materials will show their significance in the field of biomedicine.


2017 ◽  
Vol 5 (31) ◽  
pp. 6348-6355 ◽  
Author(s):  
Yiwen Tang ◽  
Ming Kong ◽  
Xiaohe Tian ◽  
Jinghang Wang ◽  
Qingyuan Xie ◽  
...  

Two-photon (TP) microscopy has advantages for biological imaging in that it allows deeper tissue-penetration and excellent resolution compared with one-photon (OP) microscopy.


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