scholarly journals Total chemical synthesis of photoactivatable proteins for light-controlled manipulation of antigen–antibody interactions

2016 ◽  
Vol 7 (3) ◽  
pp. 1891-1895 ◽  
Author(s):  
Shan Tang ◽  
Zhengpeng Wan ◽  
Yiren Gao ◽  
Ji-Shen Zheng ◽  
Jing Wang ◽  
...  
Keyword(s):  
B Cells ◽  
Chemical Synthesis ◽  
Protein Antigen ◽  
Antigen Antibody ◽  
Antibody Interactions ◽  
Photoactivatable Proteins

We report the chemical synthesis of the first photo-activatable protein antigen that can be used to study antigen–antibody interaction mediated responses in B cells.

Hepatitis B surface antigen–antibody interactions studied by optical tweezers

2012 ◽  
Vol 6 (1) ◽  
pp. 9 ◽  
Author(s):  
Z.L. Zhou ◽  
B. Tang ◽  
A.H.W. Ngan ◽  
Z.N. Dong ◽  
Y.S. Wu
Keyword(s):  
Hepatitis B ◽  
Optical Tweezers ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Antigen Antibody ◽  
Antibody Interactions

scholarly journals Optical tweezers-based immunosensor detects femtomolar concentrations of antigens

1997 ◽  
Vol 43 (2) ◽  
pp. 379-383 ◽  
Author(s):  
Kristian Helmerson ◽  
Rani Kishore ◽  
William D Phillips ◽  
Howard H Weetall
Keyword(s):  
Optical Tweezers ◽  
Optical Trapping ◽  
Competitive Binding ◽  
Protein Antigen ◽  
Antigen Antibody

Abstract We used optical tweezers (optical trapping technology) to measure the force required to separate antigen–antibody bonds. Under competitive-binding conditions, we used the force determination to detect and measure protein antigen concentrations as small as 1 fmol/L (10−15 mol/L).

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