scholarly journals Access to enantioenriched 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter by Pd-catalyzed asymmetric intermolecular Heck reaction

2015 ◽  
Vol 6 (8) ◽  
pp. 4807-4811 ◽  
Author(s):  
Gustavo M. Borrajo-Calleja ◽  
Vincent Bizet ◽  
Thomas Bürgi ◽  
Clément Mazet
Keyword(s):  
Heck Reaction ◽  
Asymmetric Heck Reaction ◽  
Palladium Catalyzed

A palladium catalyzed intermolecular asymmetric Heck reaction provides access to valuable 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter with high levels of regio- and enantiocontrol.

ChemInform Abstract: Kinetic Resolution of 2-Substituted-2,3-dihydrofurans by a Palladium-Catalyzed Asymmetric Heck Reaction.

ChemInform ◽  
2016 ◽  
Vol 47 (6) ◽  
pp. no-no
Author(s):  
Hao Li ◽  
Shi-Li Wan ◽  
Chang-Hua Ding ◽  
Bin Xu ◽  
Xue-Long Hou
Keyword(s):  
Heck Reaction ◽  
Kinetic Resolution ◽  
Asymmetric Heck Reaction ◽  
Palladium Catalyzed

Kinetic resolution of 2-substituted-2,3-dihydrofurans by a palladium-catalyzed asymmetric Heck reaction

RSC Advances ◽  
2015 ◽  
Vol 5 (92) ◽  
pp. 75411-75414 ◽  
Author(s):  
Hao Li ◽  
Shi-Li Wan ◽  
Chang-Hua Ding ◽  
Bin Xu ◽  
Xue-Long Hou
Keyword(s):  
Heck Reaction ◽  
Kinetic Resolution ◽  
Asymmetric Heck Reaction ◽  
Palladium Catalyzed ◽  
First Time

The kinetic resolution of 2-substituted-dihydrofurans via a Pd-catalyzed asymmetric Heck reaction was realized for the first time.

Recent Developments in Heck-Type Reaction of Unactivated Alkenes and Alkyl Electrophiles

Synthesis ◽  
2020 ◽  
Author(s):  
Lili Shi ◽  
Junkai Fu ◽  
Shuangqiu Gao ◽  
Le Chang ◽  
Binglin Wang
Keyword(s):  
Heck Reaction ◽  
Alkyl Radicals ◽  
Type Reaction ◽  
The Past ◽  
Alkyl Electrophiles ◽  
Recent Developments ◽  
Palladium Catalyzed ◽  
Initial Work ◽  
Activated Olefins ◽  
Pseudo Halides

AbstractThe Mizoroki–Heck reaction is considered as one of the most ingenious and widely used methods for constructing C–C bonds. This reaction mainly focuses on activated olefins (styrenes, acrylates, or vinyl ethers) and aryl/vinyl (pseudo) halides. In comparison, the studies on unactivated alkenes and alkyl electrophiles are far less due to the low reactivity, poor selectivity, as well as competitive β-H elimination. In the past years, a growing interest has thus been devoted and significant breakthroughs have been achieved in the employment of unactivated alkenes and alkyl electrophiles as the reaction components, and this type of coupling is called as Heck-type or Heck-like reaction, which distinguishes from the traditional Heck reaction. Herein, we give a brief summary on Heck-type reaction between unactivated alkenes and alkyl electrophlies, covering its initial work, recent advancements, and mechanistic discussions.1 Introduction2 Intramolecular Heck-Type Reaction of Unactivated Alkenes and Alkyl Electrophiles2.1 Cobalt-Catalyzed Intramolecular Heck-Type Reaction2.2 Palladium-Catalyzed Intramolecular Heck-Type Reaction2.3 Nickel-Catalyzed Intramolecular Heck-Type Reaction2.4 Photocatalysis and Multimetallic Protocol for Intramolecular Heck-Type Reaction3 Intermolecular Heck-Type Reaction of Unactivated Alkenes and Alkyl Electrophiles3.1 Electrophilic Trifluoromethylating Reagent as Reaction Partners3.2 Alkyl Electrophiles as Reaction Partners4 Oxidative Heck-Type Reaction of Unactivated Alkenes and Alkyl Radicals5 Conclusions and Outlook

Palladium-Catalyzed Olefinations of Aryl Halides (Heck Reaction) and Related Transformations

ChemInform ◽  
2005 ◽  
Vol 36 (44) ◽  
Author(s):  
Matthias Beller ◽  
Alexander Zapf ◽  
Thomas H. Riermeier
Keyword(s):  
Heck Reaction ◽  
Aryl Halides ◽  
Palladium Catalyzed
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