scholarly journals Protein recognition by bivalent, ‘turn-on’ fluorescent molecular probes

2015 ◽  
Vol 6 (10) ◽  
pp. 5419-5425 ◽  
Author(s):  
Linor Unger-Angel ◽  
Bhimsen Rout ◽  
Tal Ilani ◽  
Miriam Eisenstein ◽  
Leila Motiei ◽  
...  
Keyword(s):  
Signal To Noise Ratio ◽  
Molecular Probes ◽  
Fluorescence Probes ◽  
Protein Recognition ◽  
High Signal ◽  
Thiazole Orange ◽  
Turn On ◽  
Intercalating Dye ◽  
Protein Binders ◽  
Fluorescent Molecular Probes

The selective and sensitive identification of different proteins becomes possible by modifying the known intercalating dye, thiazole orange, with two protein binders. These ‘turn-on’ fluorescence probes enable the identification of acetylcholinesterase, glutathione-s-transferases and avidin with high affinity, specificity, and high signal-to-noise ratio.

The development of an ICT-based formaldehyde-responsive fluorescence turn-on probe with a high signal-to-noise ratio

2018 ◽  
Vol 42 (15) ◽  
pp. 12361-12364 ◽  
Author(s):  
Xueling Yang ◽  
Longwei He ◽  
Kaixin Xu ◽  
Yunzhen Yang ◽  
Weiying Lin
Keyword(s):  
Signal To Noise Ratio ◽  
High Signal ◽  
Signal To Noise ◽  
Turn On ◽  
Noise Ratio ◽  
Fluorescence Turn On

An ICT-based formaldehyde fluorescence turn-on probe (PBD-FA) with a high signal-to-noise ratio was judiciously constructed for bio-applications.

scholarly journals Near-infrared turn-on fluorescent probe for discriminative detection of Cys and application in in vivo imaging

RSC Advances ◽  
2019 ◽  
Vol 9 (71) ◽  
pp. 41431-41437 ◽  
Author(s):  
Shaolong Qi ◽  
Lubao Zhu ◽  
Xinyu Wang ◽  
Jianshi Du ◽  
Qingbiao Yang ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Biological Samples ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Signal To Noise Ratio ◽  
High Signal ◽  
Biological Detection ◽  
Signal To Noise ◽  
Turn On

Near-infrared (NIR) fluorescent probes are widely employed in biological detection because of their lower damage to biological samples, low background interference, and high signal-to-noise ratio.

scholarly journals Broad Applications of Thiazole Orange in Fluorescent Sensing of Biomolecules and Ions

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2828
Author(s):  
Ohad Suss ◽  
Leila Motiei ◽  
David Margulies
Keyword(s):  
Metal Ions ◽  
Building Blocks ◽  
Molecular Probes ◽  
Thiazole Orange ◽  
Background Signal ◽  
Fluorescent Sensing ◽  
Turn On ◽  
The Past ◽  
Tremendous Progress ◽  
Made In

Fluorescent sensing of biomolecules has served as a revolutionary tool for studying and better understanding various biological systems. Therefore, it has become increasingly important to identify fluorescent building blocks that can be easily converted into sensing probes, which can detect specific targets with increasing sensitivity and accuracy. Over the past 30 years, thiazole orange (TO) has garnered great attention due to its low fluorescence background signal and remarkable ‘turn-on’ fluorescence response, being controlled only by its intramolecular torsional movement. These features have led to the development of numerous molecular probes that apply TO in order to sense a variety of biomolecules and metal ions. Here, we highlight the tremendous progress made in the field of TO-based sensors and demonstrate the different strategies that have enabled TO to evolve into a versatile dye for monitoring a collection of biomolecules.

A compact guided-wave EMAT with pulsed electromagnet for ferromagnetic tube inspection

2020 ◽  
Vol 64 (1-4) ◽  
pp. 951-958
Author(s):  
Tianhao Liu ◽  
Yu Jin ◽  
Cuixiang Pei ◽  
Jie Han ◽  
Zhenmao Chen
Keyword(s):  
Power Plants ◽  
Signal To Noise Ratio ◽  
Small Diameter ◽  
Performance Testing ◽  
Guided Wave ◽  
High Signal ◽  
Receiver Coil ◽  
Signal To Noise ◽  
Corrosion Defects

Small-diameter tubes that are widely used in petroleum industries and power plants experience corrosion during long-term services. In this paper, a compact inserted guided-wave EMAT with a pulsed electromagnet is proposed for small-diameter tube inspection. The proposed transducer is noncontact, compact with high signal-to-noise ratio and unattractive to ferromagnetic tubes. The proposed EMAT is designed with coils-only configuration, which consists of a pulsed electromagnet and a meander pulser/receiver coil. Both the numerical simulation and experimental results validate its feasibility on generating and receiving L(0,2) mode guided wave. The parameters for driving the proposed EMAT are optimized by performance testing. Finally, feasibility on quantification evaluation for corrosion defects was verified by experiments.

Application of Novel Low Current OBIRCH Amplifier and Nanoprobing to Identify Subtle Leakages in Advanced Node Technologies

2018 ◽  
Author(s):  
Satish Kodali ◽  
Liangshan Chen ◽  
Yuting Wei ◽  
Tanya Schaeffer ◽  
Chong Khiam Oh
Keyword(s):  
Signal To Noise Ratio ◽  
Semiconductor Industry ◽  
Fault Isolation ◽  
Ring Oscillator ◽  
High Signal ◽  
The Novel ◽  
Resistance Change ◽  
Three Samples ◽  
Relative Threshold ◽  
First Time

Abstract Optical beam induced resistance change (OBIRCH) is a very well-adapted technique for static fault isolation in the semiconductor industry. Novel low current OBIRCH amplifier is used to facilitate safe test condition requirements for advanced nodes. This paper shows the differences between the earlier and novel generation OBIRCH amplifiers. Ring oscillator high standby leakage samples are analyzed using the novel generation amplifier. High signal to noise ratio at applied low bias and current levels on device under test are shown on various samples. Further, a metric to demonstrate the SNR to device performance is also discussed. OBIRCH analysis is performed on all the three samples for nanoprobing of, and physical characterization on, the leakage. The resulting spots were calibrated and classified. It is noted that the calibration metric can be successfully used for the first time to estimate the relative threshold voltage of individual transistors in advanced process nodes.

scholarly journals VS2 as saturable absorber for Q-switched pulse generation

Nanophotonics ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 2569-2576 ◽  
Author(s):  
Lu Li ◽  
Lihui Pang ◽  
Qiyi Zhao ◽  
Yao Wang ◽  
Wenjun Liu
Keyword(s):  
Saturable Absorber ◽  
Nonlinear Optical ◽  
Modulation Depth ◽  
Signal To Noise Ratio ◽  
Transition Metal Dichalcogenides ◽  
Laser Cavity ◽  
Pulse Generation ◽  
High Signal ◽  
Power Pulse ◽  
Metal Dichalcogenides

AbstractTransition metal dichalcogenides have been widely utilized as nonlinear optical materials for laser pulse generation applications. Herein, we study the nonlinear optical properties of a VS2-based optical device and its application as a new saturable absorber (SA) for high-power pulse generation. Few-layer VS2 nanosheets are deposited on the tapered region of a microfiber to form an SA device, which shows a modulation depth of 40.52%. After incorporating the microfiber-VS2 SA into an Er-doped fiber laser cavity, passively Q-switched pulse trains could be obtained with repetition rates varying from 95 to 233 kHz. Under the pump power of 890 mW, the largest output power and shortest pulse duration are measured to be 43 mW and 854 ns, respectively. The high signal-to-noise ratio of 60 dB confirms the excellent stability of the Q-switching state. To the best of our knolowdge, this is the first illustration of using VS2 as an SA. Our experimental results demonstrate that VS2 nanomaterials have a large potential for nonlinear optics applications.

scholarly journals Detection and localization of multiple small damages in beam

2021 ◽  
Vol 13 (1) ◽  
pp. 168781402098732
Author(s):  
Ayisha Nayyar ◽  
Ummul Baneen ◽  
Syed Abbas Zilqurnain Naqvi ◽  
Muhammad Ahsan
Keyword(s):  
Frequency Response ◽  
Natural Frequencies ◽  
Signal To Noise Ratio ◽  
Moving Average ◽  
A Priori ◽  
Damage Index ◽  
High Signal ◽  
Frequency Range ◽  
Spatial Locality ◽  
System Frequency

Localizing small damages often requires sensors be mounted in the proximity of damage to obtain high Signal-to-Noise Ratio in system frequency response to input excitation. The proximity requirement limits the applicability of existing schemes for low-severity damage detection as an estimate of damage location may not be known  a priori. In this work it is shown that spatial locality is not a fundamental impediment; multiple small damages can still be detected with high accuracy provided that the frequency range beyond the first five natural frequencies is utilized in the Frequency response functions (FRF) curvature method. The proposed method presented in this paper applies sensitivity analysis to systematically unearth frequency ranges capable of elevating damage index peak at correct damage locations. It is a baseline-free method that employs a smoothing polynomial to emulate reference curvatures for the undamaged structure. Numerical simulation of steel-beam shows that small multiple damages of severity as low as 5% can be reliably detected by including frequency range covering 5–10th natural frequencies. The efficacy of the scheme is also experimentally validated for the same beam. It is also found that a simple noise filtration scheme such as a Gaussian moving average filter can adequately remove false peaks from the damage index profile.

scholarly journals Understanding PI-QUAL for prostate MRI quality: a practical primer for radiologists

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Francesco Giganti ◽  
Alex Kirkham ◽  
Veeru Kasivisvanathan ◽  
Marianthi-Vasiliki Papoutsaki ◽  
Shonit Punwani ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Signal To Noise Ratio ◽  
High Signal ◽  
Diagnostic Quality ◽  
Prostate Mri ◽  
Prostate Imaging ◽  
Dynamic Contrast Enhanced ◽  
Diffusion Weighted ◽  
Contrast Enhanced

AbstractProstate magnetic resonance imaging (MRI) of high diagnostic quality is a key determinant for either detection or exclusion of prostate cancer. Adequate high spatial resolution on T2-weighted imaging, good diffusion-weighted imaging and dynamic contrast-enhanced sequences of high signal-to-noise ratio are the prerequisite for a high-quality MRI study of the prostate. The Prostate Imaging Quality (PI-QUAL) score was created to assess the diagnostic quality of a scan against a set of objective criteria as per Prostate Imaging-Reporting and Data System recommendations, together with criteria obtained from the image. The PI-QUAL score is a 1-to-5 scale where a score of 1 indicates that all MR sequences (T2-weighted imaging, diffusion-weighted imaging and dynamic contrast-enhanced sequences) are below the minimum standard of diagnostic quality, a score of 3 means that the scan is of sufficient diagnostic quality, and a score of 5 implies that all three sequences are of optimal diagnostic quality. The purpose of this educational review is to provide a practical guide to assess the quality of prostate MRI using PI-QUAL and to familiarise the radiologist and all those involved in prostate MRI with this scoring system. A variety of images are also presented to demonstrate the difference between suboptimal and good prostate MR scans.

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