scholarly journals Solid-phase synthesis provides a modular, lysine-based platform for fluorescent discrimination of nitroxyl and biological thiols

2015 ◽  
Vol 6 (7) ◽  
pp. 4131-4140 ◽  
Author(s):  
Andrei Loas ◽  
Robert J. Radford ◽  
Alexandria Deliz Liang ◽  
Stephen J. Lippard
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Live Cells ◽  
Phase Synthesis ◽  
Phase Approach

A synthetically facile solid-phase approach yields fluorescent Cu(ii)-based lysine conjugates which selectively detect nitroxyl and thiols in live cells.

scholarly journals A solid-phase approach for the synthesis of α-aminoboronic acid peptides

RSC Advances ◽  
2018 ◽  
Vol 8 (6) ◽  
pp. 3343-3347 ◽  
Author(s):  
Blake E. Daniels ◽  
Craig E. Stivala
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Phase Approach ◽  
Polystyrene Resin

A solid-phase synthesis of α-aminoboronic acid peptides using a 1-glycerol polystyrene resin is described.

Synthesis of Asparagusic Acid Modified Lysine and its Application in Solid-Phase Synthesis of Peptides with Enhanced Cellular Uptake

Synlett ◽  
2017 ◽  
Vol 29 (10) ◽  
pp. 1289-1292 ◽  
Author(s):  
Pablo Rivera-Fuentes ◽  
Alina Tirla ◽  
Moritz Hansen
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
Cellular Uptake ◽  
Building Block ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Live Cells ◽  
Phase Synthesis ◽  
Scalable Synthesis

Cyclic disulfides, such as asparagusic acid, enhance the uptake of a variety of cargoes into live cells. Here, we report a robust and scalable synthesis of an asparagusic acid modified lysine. This amino acid can be used in solid-phase peptide synthesis. We confirmed that incorporation of this building block into the sequence of a peptide increases its cellular uptake substantially.

Towards a general solid phase approach for the iterative synthesis of conjugated oligomers using a germanium based linker - first solid phase synthesis of an oligo-(triarylamine)

2007 ◽  
Vol 5 (11) ◽  
pp. 1752-1763 ◽  
Author(s):  
David J. Turner ◽  
Rémi Anémian ◽  
Philip R. Mackie ◽  
Domenico C. Cupertino ◽  
Stephen G. Yeates ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Conjugated Oligomers ◽  
Phase Synthesis ◽  
Phase Approach ◽  
Iterative Synthesis
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