Bio-inspired Janus composite nanoscrolls for on-demand tumour targeting

RSC Advances ◽  
2016 ◽  
Vol 6 (21) ◽  
pp. 17179-17187 ◽  
Author(s):  
Jeong-Hwan Kim ◽  
Tsai-Ming Lu
Keyword(s):  
Near Infrared ◽  
Tumour Targeting ◽  
On Demand ◽  
Nir Light

Inspired by the responsive characteristics of natural fibrous counterparts, triple stimuli, pH-, drug-, and near-infrared (NIR) light-responsive Janus composite nanosheets (JCNs) were investigated.

scholarly journals Photophysics and photochemistry of NIR absorbers derived from cyanines: key to new technologies based on chemistry 4.0

2020 ◽  
Vol 16 ◽  
pp. 415-444 ◽  
Author(s):  
Bernd Strehmel ◽  
Christian Schmitz ◽  
Ceren Kütahya ◽  
Yulian Pang ◽  
Anke Drewitz ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
High Power ◽  
Near Infrared ◽  
New Technologies ◽  
Light Sources ◽  
Hydrophobic Properties ◽  
On Demand ◽  
Nir Light ◽  
Photothermal Treatment ◽  
End Groups

Cyanines derived from heptamethines were mainly discussed regarding their functionalization to broaden the solubility in different surroundings exhibiting either hydrophilic or hydrophobic properties and to tailor made the ΔG et photopysical properties with respect to absorption and fluorescence. Electrochemical properties were additionally considered for some selected examples. The cyanines chosen comprised as end groups either indolenine, benzo[e]- or benzo[cd]indolium pattern, which facilitated to shift the absorption between 750–1000 nm. This enabled their use in applications with light sources emitting in the near-infrared (NIR) region selected from high power LEDs or lasers with line-shaped focus. The absorbers considered were discussed regarding their function as sensitizer for applications related to Chemistry 4.0 standards. These were mainly photopolymer coatings, which can be found for applications in the graphic industry or to protect selected substrates. The huge release of heat on demand upon turning ON or OFF the NIR light source enables them for photothermal treatment in processes requesting heat to initiate either chemical (activated reactions) or physical (melting, evaporation) events.

scholarly journals Nanocomposite Sprayed Films with Photo-Thermal Properties for Remote Bacteria Eradication

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 786 ◽  
Author(s):  
Mykola Borzenkov ◽  
Giuseppe Chirico ◽  
Piersandro Pallavicini ◽  
Paola Sperandeo ◽  
Alessandra Polissi ◽  
...  
Keyword(s):  
Near Infrared ◽  
Light Exposure ◽  
Antibacterial Properties ◽  
Remarkable Effect ◽  
On Demand ◽  
Nir Light ◽  
Positive Strain ◽  
Glass Slides ◽  
Active Nanoparticles ◽  
Further Development

Currently there is a strong demand for novel protective materials with efficient antibacterial properties. Nanocomposite materials loaded with photo-thermally active nanoparticles can offer promising opportunities due to the local increase of temperature upon near-infrared (NIR) light exposure capable of eradicating bacteria. In this work, we fabricated antibacterial films obtained by spraying on glass slides aqueous solutions of polymers, containing highly photo-thermally active gold nanostars (GNS) or Prussian Blue (PB) nanoparticles. Under NIR light irradiation with low intensities (0.35 W/cm2) these films demonstrated a pronounced photo-thermal effect: ΔTmax up to 26.4 °C for the GNS-containing films and ΔTmax up to 45.8 °C for the PB-containing films. In the latter case, such a local temperature increase demonstrated a remarkable effect on a Gram-negative strain (P. aeruginosa) killing (84% of dead bacteria), and a promising effect on a Gram-positive strain (S. aureus) eradication (69% of dead bacteria). The fabricated films are promising prototypes for further development of lightweight surfaces with efficient antibacterial action that can be remotely activated on demand.

scholarly journals Near-infrared light-triggered nano-prodrug for cancer gas therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Runcong Liu ◽  
Yongjun Peng ◽  
Ligong Lu ◽  
Shaojun Peng ◽  
Tianfeng Chen ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Near Infrared ◽  
Treatment Method ◽  
Infrared Light ◽  
Deep Penetration ◽  
Normal Tissues ◽  
On Demand ◽  
Nir Light ◽  
Gas Molecules ◽  
Ongoing Development

AbstractGas therapy (GT) has attracted increasing attention in recent years as a new cancer treatment method with favorable therapeutic efficacy and reduced side effects. Several gas molecules, such as nitric oxide (NO), carbon monoxide (CO), hydrogen (H2), hydrogen sulfide (H2S) and sulfur dioxide (SO2), have been employed to treat cancers by directly killing tumor cells, enhancing drug accumulation in tumors or sensitizing tumor cells to chemotherapy, photodynamic therapy or radiotherapy. Despite the great progress of gas therapy, most gas molecules are prone to nonspecific distribution when administered systemically, resulting in strong toxicity to normal tissues. Therefore, how to deliver and release gas molecules to targeted tissues on demand is the main issue to be considered before clinical applications of gas therapy. As a specific and noninvasive stimulus with deep penetration, near-infrared (NIR) light has been widely used to trigger the cleavage and release of gas from nano-prodrugs via photothermal or photodynamic effects, achieving the on-demand release of gas molecules with high controllability. In this review, we will summarize the recent progress in cancer gas therapy triggered by NIR light. Furthermore, the prospects and challenges in this field are presented, with the hope for ongoing development.

scholarly journals Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes

2015 ◽  
Vol 112 (51) ◽  
pp. 15719-15724 ◽  
Author(s):  
Alina Y. Rwei ◽  
Jung-Jae Lee ◽  
Changyou Zhan ◽  
Qian Liu ◽  
Meryem T. Ok ◽  
...  
Keyword(s):  
Cell Culture ◽  
Sciatic Nerve ◽  
Local Anesthesia ◽  
Nerve Block ◽  
Near Infrared ◽  
Tissue Reaction ◽  
On Demand ◽  
Nir Light

Pain management would be greatly enhanced by a formulation that would provide local anesthesia at the time desired by patients and with the desired intensity and duration. To this end, we have developed near-infrared (NIR) light-triggered liposomes to provide on-demand adjustable local anesthesia. The liposomes contained tetrodotoxin (TTX), which has ultrapotent local anesthetic properties. They were made photo-labile by encapsulation of a NIR-triggerable photosensitizer; irradiation at 730 nm led to peroxidation of liposomal lipids, allowing drug release. In vitro, 5.6% of TTX was released upon NIR irradiation, which could be repeated a second time. The formulations were not cytotoxic in cell culture. In vivo, injection of liposomes containing TTX and the photosensitizer caused an initial nerve block lasting 13.5 ± 3.1 h. Additional periods of nerve block could be induced by irradiation at 730 nm. The timing, intensity, and duration of nerve blockade could be controlled by adjusting the timing, irradiance, and duration of irradiation. Tissue reaction to this formulation and the associated irradiation was benign.

Catalyst Halogenation Enables Rapid and Efficient Polymerizations with Visible to Near-Infrared Light

2020 ◽  
Author(s):  
Alex Stafford ◽  
Dowon Ahn ◽  
Emily Raulerson ◽  
Kun-You Chung ◽  
Kaihong Sun ◽  
...  
Keyword(s):  
Near Infrared ◽  
Transient Absorption ◽  
Reaction Times ◽  
Infrared Light ◽  
Structure Property ◽  
Light Emitting ◽  
Structure Property Relationships ◽  
Nir Light ◽  
Light Intensities ◽  
Emission Quenching

Driving rapid polymerizations with visible to near-infrared (NIR) light will enable nascent technologies in the emerging fields of bio- and composite-printing. However, current photopolymerization strategies are limited by long reaction times, high light intensities, and/or large catalyst loadings. Improving efficiency remains elusive without a comprehensive, mechanistic evaluation of photocatalysis to better understand how composition relates to polymerization metrics. With this objective in mind, a series of methine- and aza-bridged boron dipyrromethene (BODIPY) derivatives were synthesized and systematically characterized to elucidate key structure-property relationships that facilitate efficient photopolymerization driven by visible to NIR light. For both BODIPY scaffolds, halogenation was shown as a general method to increase polymerization rate, quantitatively characterized using a custom real-time infrared spectroscopy setup. Furthermore, a combination of steady-state emission quenching experiments, electronic structure calculations, and ultrafast transient absorption revealed that efficient intersystem crossing to the lowest excited triplet state upon halogenation was a key mechanistic step to achieving rapid photopolymerization reactions. Unprecedented polymerization rates were achieved with extremely low light intensities (< 1 mW/cm<sup>2</sup>) and catalyst loadings (< 50 μM), exemplified by reaction completion within 60 seconds of irradiation using green, red, and NIR light-emitting diodes.

Bi19S27I3 nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

Nanoscale ◽  
2021 ◽  
Author(s):  
Jinsong Xiong ◽  
Qinghuan Bian ◽  
Shuijin Lei ◽  
Yatian Deng ◽  
Kehan Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Research Interest ◽  
The Past ◽  
Nir Light ◽  
Considerable Research ◽  
Key Factor

Near-infrared (NIR) light induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in the photothermal therapy...

scholarly journals Near-Infrared-Triggered Upconverting Nanoparticles for Biomedicine Applications

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 756
Author(s):  
Manoj Kumar Mahata ◽  
Ranjit De ◽  
Kang Taek Lee
Keyword(s):  
Drug Delivery ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Cutting Edge ◽  
Clinical Translation ◽  
Basic Knowledge ◽  
Nanotechnology Research ◽  
Nir Light

Due to the unique properties of lanthanide-doped upconverting nanoparticles (UCNP) under near-infrared (NIR) light, the last decade has shown a sharp progress in their biomedicine applications. Advances in the techniques for polymer, dye, and bio-molecule conjugation on the surface of the nanoparticles has further expanded their dynamic opportunities for optogenetics, oncotherapy and bioimaging. In this account, considering the primary benefits such as the absence of photobleaching, photoblinking, and autofluorescence of UCNPs not only facilitate the construction of accurate, sensitive and multifunctional nanoprobes, but also improve therapeutic and diagnostic results. We introduce, with the basic knowledge of upconversion, unique properties of UCNPs and the mechanisms involved in photon upconversion and discuss how UCNPs can be implemented in biological practices. In this focused review, we categorize the applications of UCNP-based various strategies into the following domains: neuromodulation, immunotherapy, drug delivery, photodynamic and photothermal therapy, bioimaging and biosensing. Herein, we also discuss the current emerging bioapplications with cutting edge nano-/biointerfacing of UCNPs. Finally, this review provides concluding remarks on future opportunities and challenges on clinical translation of UCNPs-based nanotechnology research.

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

scholarly journals Photothermal Therapy Using Gold Nanorods and Near-Infrared Light in a Murine Melanoma Model Increases Survival and Decreases Tumor Volume

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mary K. Popp ◽  
Imane Oubou ◽  
Colin Shepherd ◽  
Zachary Nager ◽  
Courtney Anderson ◽  
...  
Keyword(s):  
Light Source ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Volume ◽  
Infrared Light ◽  
Led Light ◽  
Murine Melanoma ◽  
Nir Light ◽  
Melanoma Model

Photothermal therapy (PTT) treatments have shown strong potential in treating tumors through their ability to target destructive heat preferentially to tumor regions. In this paper we demonstrate that PTT in a murine melanoma model using gold nanorods (GNRs) and near-infrared (NIR) light decreases tumor volume and increases animal survival to an extent that is comparable to the current generation of melanoma drugs. GNRs, in particular, have shown a strong ability to reach ablative temperatures quickly in tumors when exposed to NIR light. The current research tests the efficacy of GNRs PTT in a difficult and fast growing murine melanoma model using a NIR light-emitting diode (LED) light source. LED light sources in the NIR spectrum could provide a safer and more practical approach to photothermal therapy than lasers. We also show that the LED light source can effectively and quickly heatin vitroandin vivomodels to ablative temperatures when combined with GNRs. We anticipate that this approach could have significant implications for human cancer therapy.

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

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