Biodegradable multi-blocked polyurethane micelles for intracellular drug delivery: the effect of disulfide location on the drug release profile

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 9082-9089 ◽  
Author(s):  
Yongchao Yao ◽  
He Xu ◽  
Chang Liu ◽  
Yayuan Guan ◽  
Deqiu Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Disulfide Bonds ◽  
Drug Carriers ◽  
Antitumor Drug ◽  
Release Profile ◽  
Drug Release Profile ◽  
Intracellular Drug Delivery

Polyurethane micelles with disulfide bonds positioned mainly either at the hydrophobic PCL junctions (PU-SS-C) or at the connections between the hydrophilic PEG and hydrophobic PCL blocks (PU-SS-I) were developed as a antitumor drug carriers.

scholarly journals Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation

2017 ◽  
Vol 2017 ◽  
pp. 1-12
Author(s):  
Abdul Karim ◽  
Muhammad Ashraf Shaheen ◽  
Tahir Mehmood ◽  
Abdul Rauf Raza ◽  
Musadiq Aziz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Lag Time ◽  
Zero Order ◽  
Release Profile ◽  
Drug Release Profile ◽  
Independent Variables ◽  
Zero Order Kinetics ◽  
Model Drug ◽  
Predicted Values

The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS). A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug and formulations have been prepared utilizing 32factorial designs. The drug release (DR) data has been subjected to various kinetic models to investigate the DR mechanism. A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increasing the concentration of tragacanth (TG) and citric acid (CA) with an increment in floating time. The stearic acid (SA) has been used to decrease the lag time because a decrease in density of system was observed. The kinetic analysis showed that the optimized formulation (S4F3) followed zero-order kinetics and power law was found to be best fitted due to its minimum lag time and maximum floating ability. The resemblance of observed and predicted values indicated the validity of derived equations for evaluating the effect of independent variables while kinetic study demonstrated that the applied models are feasible for evaluating and developing float for RNT.

scholarly journals Preparation and characterization of azathioprine microspheres for colon specific delivery

2019 ◽  
Vol 9 (2) ◽  
pp. 97-101
Author(s):  
Rinku Gonekar ◽  
Mohan Lal Kori
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Study Drug ◽  
Entrapment Efficiency ◽  
Release Profile ◽  
Intestinal Fluid ◽  
Drug Release Profile ◽  
Fecal Matter

The objective of the present study is to develop colon targeted drug delivery system using dextrin (polysaccharide) as a carrier for Azathioprine.  Microspheres containing azathioprine, dextrin and various excipients were prepared by solvent evaporation technique. The prepared microsphere were evaluated by different methods parameters like particle size,  drug entrapment efficiency, percentage yield, shape and surface morphology  and in vitro drug release study. Drug release profile was evaluated in simulated gastric, intestinal fluid and simulated colonic fluid. Best formulation was decided on the basis drug release profile in simulated gastric, intestinal fluid and simulated colonic fluid. In dextrin based microspheres, dextrin as a carrier was found to be suitable for targeting of Azathioprine for local action in the site of colon. Dextrin microspheres released 95-99% of azathioprine in simulated colonic fluid with 4% human fecal matter solution. The results of in-vitro studies of the azathioprine microspheres indicate that for colon targeting dextrin are suitable carriers to deliver the drug specifically in the colonic region. Dextrin based azathoprine microspheres showed no significance change in particle size and % residual upon storage at 5 ± 3ºC, 25 ± 2ºC/60 ± 5% RH (room temperature) and 40 ± 2ºC/75 ±5%RH humidity for three months. Keywords: azathioprine, microsphere, dextrin, colon specific drug delivery.

Hydrogel-Forming Microneedle Arrays for Sustained and Controlled Ocular Drug Delivery

2020 ◽  
Vol 3 (4) ◽  
Author(s):  
Maher Amer ◽  
Roland K. Chen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Kinetics ◽  
Therapeutic Index ◽  
Ocular Drug Delivery ◽  
Release Profile ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Sustained Drug Delivery ◽  
Kinetics Of

Abstract Microneedles (MNs) provide a minimally invasive alternative to intravitreal injections and a promising means to sustainable ocular drug delivery. To optimize the sustained drug release profile and to ease the administration of the MN array to the eye, the number of MNs in an MN array and their layout need to be carefully selected. In this study, the drug release kinetics of MN arrays with varying numbers of MNs (8, 12, and 16) is studied over a four-week period. The MN arrays show a much more uniform drug release profile than the single injections. Only the 16-needle MN array fully released all the amount of loaded drug at the end of the 4-week period. Both 8- and 12-needle arrays showed a steady release rate over the 4-week period, which is the longest sustained release duration that has been reported. Zero-order models are created to predict drug release profiles for the three MN arrays. It is estimated that the MN array with 8 needles can deliver the drug for up to 6 weeks. The models can be used to design MN arrays with a given targeted therapeutic index for sustained drug delivery.

Antibacterial chitosan-copolymer membranes for drug delivery: synthesis, characterization, drug release profile and kinetics

2017 ◽  
Vol 92 (7) ◽  
pp. 1659-1666 ◽  
Author(s):  
Raja S Azarudeen ◽  
Marimuthu Thirumarimurugan ◽  
K Padmadhas Athmiya ◽  
Rengaswamy Monisha ◽  
Venkatasamy Prashanthini
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Profile ◽  
Drug Release Profile

scholarly journals Synthesis and drug release profile of a dual-responsive poly(ethylene glycol) hydrogel nanocomposite

RSC Advances ◽  
2017 ◽  
Vol 7 (44) ◽  
pp. 27637-27644 ◽  
Author(s):  
Ernandes Taveira Tenório-Neto ◽  
Diego de Souza Lima ◽  
Marcos Rogério Guilherme ◽  
Michele Karoline Lima-Tenório ◽  
Débora Botura Scariot ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Release Profile ◽  
Poly Ethylene Glycol ◽  
Drug Release Profile ◽  
Dual Responsive ◽  
Poly Ethylene ◽  
Hydrogel Nanocomposite

This work describes the synthesis, characterization and application of a pH- and magnetic-responsive PEG hydrogel (HG) nanocomposite as a platform for drug delivery.

scholarly journals Polymers Blending as Release Modulating Tool in Drug Delivery

2021 ◽  
Vol 8 ◽  
Author(s):  
Parisa Ghasemiyeh ◽  
Soliman Mohammadi-Samani
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Release Profile ◽  
Core Shell ◽  
Drug Release Profile ◽  
Polymer Blending ◽  
Different Types ◽  
Kinetics Of ◽  
Physical Mixtures

Different polymeric materials have been used as drug delivery vehicles for decades. Natural, semisynthetic, and synthetic polymers each have their own specific characteristics and, due to the physicochemical limitations of each polymer, tuning the release rate and targeting the active ingredient to a specific organ or site of action is a complicated task for pharmaceutical scientists. In this regard, polymer blending has been considered as an attractive approach to fabricate novel and unique drug delivery systems with modified physical and/or chemical characteristics. There are three major polymer blending approaches that are used for drug delivery purposes: physical mixtures, core-shell model, and block copolymer model. Each of these types of polymer blends could significantly affect the loading capacities and the kinetics of drug release from the relevant formulations. Drug release from these blended polymers can be tuned through the changes in temperature and pH of the environment, and physiochemical properties of the target organs. Furthermore, the possible molecular interactions among polymers and drug molecules can significantly affect the drug release profile from these blended polymeric micro- and nanocarriers. In this review, first of all, different types of polymers and their various applications in biomedical sciences have been discussed and smart or stimuli responsive polymers are introduced and categorized based on their nature. Then, the purpose of polymer blending in drug delivery systems has been discussed. Different types of polymer blends including physical mixtures, core-shell polymeric carriers, and block copolymers have been summarized with focus on the effect of polymer blending on encapsulated drug release profiles. Finally, the consequence of each blending approach on drug release profile and kinetics of drug release have been mentioned in tabular format.

Drug Release Profile Study of Gentamicin Encapsulated Poly(lactic Acid) Microspheres for Drug Delivery

2019 ◽  
Vol 17 ◽  
pp. 836-845
Author(s):  
T.T.T. Trang ◽  
M. Mariatti ◽  
H.Y. Badrul ◽  
K. Masakazu ◽  
X.T.T. Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Release ◽  
Release Profile ◽  
Poly Lactic Acid ◽  
Drug Release Profile ◽  
Profile Study

scholarly journals Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 333 ◽  
Author(s):  
João Nogueira ◽  
Sofia F. Soares ◽  
Carlos O. Amorim ◽  
João S. Amaral ◽  
Cláudia Silva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Drug Loading ◽  
Drug Carriers ◽  
Release Profile ◽  
Loading Capacity ◽  
Drug Release Profile ◽  
Blood Ph ◽  
Alternative Drug ◽  
Doxorubicin Release

Doxorubicin is one of the most widely used anti-cancer drugs, but side effects and selectivity problems create a demand for alternative drug delivery systems. Herein we describe a hybrid magnetic nanomaterial as a pH-dependent doxorubicin release carrier. This nanocarrier comprises magnetic iron oxide cores with a diameter of 10 nm, enveloped in a hybrid material made of siliceous shells and ĸ-carrageenan. The hybrid shells possess high drug loading capacity and a favorable drug release profile, while the iron oxide cores allows easy manipulation via an external magnetic field. The pH responsiveness was assessed in phosphate buffers at pH levels equivalent to those of blood (pH 7.4) and tumor microenvironment (pH 4.2 and 5). The nanoparticles have a loading capacity of up to 12.3 wt.% and a release profile of 80% in 5 h at acidic pH versus 25% at blood pH. In vitro drug delivery tests on human breast cancer and non-cancer cellular cultures have shown that, compared to the free drug, the loaded nanocarriers have comparable antiproliferative effect but a less intense cytotoxic effect, especially in the non-cancer cell line. The results show a clear potential for these new hybrid nanomaterials as alternative drug carriers for doxorubicin.

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