Highly stretchable and tough pH-sensitive hydrogels with reversible swelling and recoverable deformation

RSC Advances ◽  
2016 ◽  
Vol 6 (6) ◽  
pp. 4850-4857 ◽  
Author(s):  
Xue Jiao Liu ◽  
Hai Qiang Li ◽  
Bao Yuan Zhang ◽  
Ya Jun Wang ◽  
Xiu Yan Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Controlled Drug Delivery ◽  
Ph Sensitive ◽  
Stimuli Responsive ◽  
Highly Stretchable ◽  
Mechanical Performances ◽  
Responsive Hydrogels

Stimuli-responsive hydrogels are becoming increasingly important for controlled drug delivery, biosensing, and tissue engineering. It would be much advantageous for intelligent hydrogels if they exhibit superior mechanical performances.

scholarly journals Strategy to design a smart photocleavable and pH sensitive chitosan based hydrogel through a novel crosslinker: a potential vehicle for controlled drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (25) ◽  
pp. 14694-14704 ◽  
Author(s):  
Safiya Nisar ◽  
Ashiq Hussain Pandit ◽  
Li-Fang Wang ◽  
Sunita Rattan
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Ph Sensitive ◽  
Stimuli Responsive ◽  
Ph Responsive

We report the synthesis of a novel photocleavable crosslinker and its joining with amine-based polysachharides, viz. chitosan, resulting in the formation of a dual stimuli-responsive hydrogel having UV- and pH-responsive sites.

scholarly journals Hydrogel Nanoparticle as a Functional Coating Layer in Biosensing, Tissue Engineering, and Drug Delivery

Coatings ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 663
Author(s):  
Heejoo Cho ◽  
Sumin Jeon ◽  
Junghyeok Yang ◽  
Song Yi Baek ◽  
Doeun Kim
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Local Environment ◽  
Stimuli Responsive ◽  
Functional Coating ◽  
Coating Materials ◽  
Hydrogel Particles ◽  
Cross Links ◽  
Smart Coating ◽  
Responsive Hydrogels

The development of functional coating materials has resulted in many breakthroughs in the discovery of energy, environmental, and biomedical applications. Responsive polymeric hydrogels are an example of smart coating materials due to their stimuli-responsive characteristics upon changes in their local environment. This review focuses on the introduction of hydrogel nanoparticles and their applications in functional layers as responsive coating materials. Hydrogels are explained by the composition of cross-links and monomers used for preparation. In particular, an important class of responsive hydrogels, that is, nanosized hydrogel particles (nanogels), are described for thee synthesis, modification, and application in assembly of functional coating layers. Finally, nanogel functional layers for biological applications will be discussed with recent advances in biosensing, tissue engineering, and drug delivery.

scholarly journals Stimuli-responsive hydrogels in drug delivery and tissue engineering

Drug Delivery ◽  
2014 ◽  
Vol 23 (3) ◽  
pp. 748-770 ◽  
Author(s):  
Nikhil Sood ◽  
Ankur Bhardwaj ◽  
Shuchi Mehta ◽  
Abhinav Mehta
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Stimuli Responsive ◽  
Responsive Hydrogels

Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

Soft Matter ◽  
2021 ◽  
Author(s):  
Michael Meleties ◽  
Priya Katyal ◽  
Bonnie Lin ◽  
Dustin Britton ◽  
Jin Kim Montclare
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Coiled Coil ◽  
Stimuli Responsive ◽  
Tunable Properties ◽  
Stimuli Sensitive ◽  
Biomedical Fields

Owing to their tunable properties, hydrogels comprised of stimuli sensitive polymers are one of the most appealing scaffolds with applications in tissue engineering, drug delivery and other biomedical fields. We...

Stimuli-responsive hydrogels for intratumoral drug delivery

2021 ◽  
Author(s):  
Ana C. Marques ◽  
Paulo J. Costa ◽  
Sérgia Velho ◽  
Maria H. Amaral
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
Responsive Hydrogels ◽  
Intratumoral Drug Delivery

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

2021 ◽  
Vol 11 (23) ◽  
pp. 11369
Author(s):  
Ashni Arun ◽  
Pratyusha Malrautu ◽  
Anindita Laha ◽  
Hongrong Luo ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Solubility ◽  
Stimuli Responsive ◽  
Preparation Methods ◽  
Nanoparticle Preparation ◽  
Responsive Behavior ◽  
Reduced Toxicity

The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

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