A cylindrical magnetically-actuated drug delivery device proposed for minimally invasive treatment of prostate cancer

RSC Advances ◽  
2015 ◽  
Vol 5 (119) ◽  
pp. 98087-98096 ◽  
Author(s):  
P. Zachkani ◽  
J. K. Jackson ◽  
F. N. Pirmoradi ◽  
M. Chiao
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Minimally Invasive ◽  
Cancer Treatment ◽  
Minimally Invasive Treatment ◽  
Delivery Device ◽  
Invasive Treatment ◽  
Prostate Cancer Treatment ◽  
Drug Delivery Device ◽  
Magnetically Actuated

A cylindrical magnetically-actuated MEMS drug delivery device, implanted through a needle for localized prostate cancer treatment is proposed.

Magnetically-actuated drug delivery device (MADDD) for minimally invasive treatment of prostate cancer: An in vivo animal pilot study

The Prostate ◽  
2017 ◽  
Vol 77 (13) ◽  
pp. 1356-1365 ◽  
Author(s):  
Werner J. Struss ◽  
Zheng Tan ◽  
Payam Zachkani ◽  
Igor Moskalev ◽  
John K. Jackson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Pilot Study ◽  
Minimally Invasive ◽  
Minimally Invasive Treatment ◽  
Delivery Device ◽  
Invasive Treatment ◽  
Drug Delivery Device ◽  
Magnetically Actuated

scholarly journals Advances of Microneedles in Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5912
Author(s):  
Jie Xu ◽  
Danfeng Xu ◽  
Xuan Xuan ◽  
Huacheng He
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Minimally Invasive ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Wound Repair ◽  
Delivery Systems ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Different Shapes

A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

scholarly journals Fabrication of Magnetically Actuated Fluidic Drug Delivery Device Using Polyvinyl Chloride Adhesive Stencils

Micromachines ◽  
2018 ◽  
Vol 9 (7) ◽  
pp. 358 ◽  
Author(s):  
Hyun Kim ◽  
Jong-mo Seo
Keyword(s):  
Drug Delivery ◽  
Polyvinyl Chloride ◽  
Oxygen Plasma ◽  
Fabrication Method ◽  
Delivery Device ◽  
Saturation State ◽  
Drug Delivery Device ◽  
Magnetically Actuated ◽  
Plasma Treatments ◽  
Secondary Chamber

In this paper, a polydimethylsiloxane (PDMS) fabrication method is introduced. It eliminates the need for conventional fabrication methods, such as photolithography and etching. Only a series of oxygen plasma treatments, silanization, and polyvinyl chloride (PVC) adhesive stencils were used to develop multi-layer designs. The fabrication method was applied to fabricate a PDMS-based drug delivery device with an actively controllable, magnetically actuated valve. Above all, this fabrication method eliminated the use of a power-consuming pump. Fluidic substances were injected into the circular shaped primary chamber through a syringe. A secondary chamber, similar to the primary chamber’s structure but with a smaller radius and thinner membrane, was connected via a microchannel to regulate the amount released. When actuated with a permanent magnet for one second, the volume in the secondary chamber first depletes. As the magnet is removed, the valve closes. Subsequently, the primary chamber replenishes the secondary chamber. This process can be repeated until the primary chamber reaches a saturation state that can no longer inflate the secondary chamber. The device could release a few microliters per actuation. Various combinations of size and thickness of primary, and secondary chambers can realize release rate of desired amount.

scholarly journals A 3D Printed Self-Sustainable Cell-Encapsulation Drug Delivery Device for Periocular Transplant-Based Treatment of Retinal Degenerative Diseases

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 436 ◽  
Author(s):  
Hideto Kojima ◽  
Bibek Raut ◽  
Li-Jiun Chen ◽  
Nobuhiro Nagai ◽  
Toshiaki Abe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Retinal Pigment ◽  
Cell Encapsulation ◽  
Degenerative Diseases ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
3D Printed ◽  
Retinal Degenerative Diseases

Self-sustainable release of brain-derived neurotrophic factor (BDNF) to the retina using minimally invasive cell-encapsulation devices is a promising approach to treat retinal degenerative diseases (RDD). Herein, we describe such a self-sustainable drug delivery device with human retinal pigment epithelial (ARPE-19) cells (cultured on collagen coated polystyrene (PS) sheets) enclosed inside a 3D printed semi-porous capsule. The capsule was 3D printed with two photo curable polymers: triethylene glycol dimethacrylate (TEGDM) and polyethylene glycol dimethylacrylate (PEGDM). The capsule’s semi-porous membrane (PEGDM) could serve three functions: protecting the cells from body’s immune system by limiting diffusion (5.97 ± 0.11%) of large molecules like immunoglobin G (IgG)(150 kDa); helping the cells to survive inside the capsule by allowing diffusion (43.20 ± 2.16%) of small molecules (40 kDa) like oxygen and necessary nutrients; and helping in the treatment of RDD by allowing diffusion of cell-secreted BDNF to the outside environment. In vitro results showed a continuous BDNF secretion from the device for at least 16 days, demonstrating future potential of the cell-encapsulation device for the treatment of RDD in a minimally invasive and self-sustainable way through a periocular transplant.

Design and fabrication of a magnetically actuated non-invasive reusable drug delivery device

2018 ◽  
Vol 44 (7) ◽  
pp. 1070-1077 ◽  
Author(s):  
Joyline Dsa ◽  
Manish Goswami ◽  
B. R. Singh ◽  
Nidhi Bhatt ◽  
Pankaj Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Non Invasive ◽  
Magnetically Actuated

Silica‐based Nanoparticles as Drug Delivery Vehicles for Prostate Cancer Treatment

2020 ◽  
Author(s):  
Steffi Tiburcius ◽  
Kannan Krishnan ◽  
Jae‐Hun Yang ◽  
Fatemeh Hashemi ◽  
Gurwinder Singh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Treatment ◽  
Prostate Cancer Treatment ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

1077: A Novel Apoptosis-Inducing Gene and its Application in Prostate Cancer Treatment

2004 ◽  
Vol 171 (4S) ◽  
pp. 284-284
Author(s):  
Yi Lu ◽  
Jun Zhang ◽  
Ben Beheshti ◽  
Ximing J. Yang ◽  
Syamal K. Bhattacharya ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Prostate Cancer Treatment
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