scholarly journals Preparation of spherical agglomerates from potash alum

RSC Advances ◽  
2016 ◽  
Vol 6 (7) ◽  
pp. 5466-5473 ◽  
Author(s):  
Andrea F. Kardos ◽  
Judit Tóth ◽  
László Trif ◽  
János Gyenis ◽  
Tivadar Feczkó
Keyword(s):  
Core Material ◽  
Salt Hydrate ◽  
Spherical Crystallization ◽  
Spherical Agglomerates

Spherical crystallization proved to be feasible for the preparation of spherical salt hydrate particles as core material for microencapsulation.

scholarly journals Control of the crystal form by the spherical crystallization technique. Factors causing polymorphism of tolbutamide spherical agglomerates.

1991 ◽  
Vol 28 (3) ◽  
pp. 172-176
Author(s):  
Akimitsu SANO ◽  
Takeo KURIKI ◽  
Yoshiaki KAWASHIMA ◽  
Hirofumi TAKEUCHI ◽  
Tomoaki HINO ◽  
...  
Keyword(s):  
Crystal Form ◽  
Spherical Crystallization ◽  
Spherical Agglomerates

IMPROVEMENT OF DISSOLUTION RATE OF FEBUXOSTAT USING HYBRID TECHNIQUE OF SPHERICAL CRYSTALLIZATION AND SOLID DISPERSION

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (09) ◽  
pp. 32-39
Author(s):  
D. B Tandel ◽  
◽  
P. A Shah ◽  
K. G. Patel ◽  
M. C Gohel ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Drug Dissolution ◽  
In Vitro Dissolution ◽  
Compatibility Study ◽  
Hybrid Technique ◽  
Spherical Crystallization ◽  
Spherical Agglomerates ◽  
Pvp K30 ◽  
Excipient Compatibility

The present study was carried out with an aim to improve dissolution rate of febuxostat (FBX, BCSclass II) drug. Spherical agglomerates were prepared by hybrid technique of spherical crystallization and solid dispersion using different ratios of FBX and polymer (PVP K30, HPMC E3LV and chitosan). Drug excipient compatibility study was evaluated by Fourier transform infrared spectroscopy and X-ray diffractometry. Scanning electron microscopy was used for measurement of size of agglomerate. In vitro dissolution study of prepared spherical agglomerates was compared with untreated FBX and marketed formulation in phosphate buffer pH 6.8. The ratio of drug to polymer also affected the drug dissolution results. Drug excipient compatibility study showed no interaction between FBX and PVP K30 (1:5) polymer. The use of PVP K30 (1:5) resulted in partial amorphization and improved drug dissolution. Direct compression method can be adopted in manufacturing to simplify the validation efforts. The performance of the formulated product was superior to the marketed product in the in vitro dissolution test.

scholarly journals Simple and Efficient Spherical Crystallization of Clopidogrel Bisulfate Form-I via Anti-Solvent Crystallization Method

Crystals ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 53 ◽  
Author(s):  
Ji-Hun An ◽  
Alice Nguvoko Kiyonga ◽  
Eun Hee Lee ◽  
Kiwon Jung
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Processing Parameters ◽  
Polymorphic Form ◽  
Form Processing ◽  
Solvent Crystallization ◽  
Clopidogrel Bisulfate ◽  
Spherical Crystallization ◽  
Spherical Agglomerates

Clopidogrel bisulfate (CLP) form-I crystals are irregular, rectangular-shaped crystals. Because of their poor compressibility, flowability and their strong surface tension, manufacturers apply spherical crystallization methods to produce CLP form-I spherical agglomerates with a uniform particle size distribution. Consequently, manufacturers primarily synthesize CLP form-I crystal salts utilizing very complex methods, which produces form-I spherical agglomerates by means of spherical crystallization. In this study, spherical crystals of CLP Form-I were directly prepared from CLP Form-II, the most stable polymorph at room temperature, by using ethanol as solvent and a mixture of isopropyl alcohol (IPA)/n-Hexane (Hex) as an anti-solvent. To provide systematic inputs for the development of spherical agglomerates of optimal morphology, size, particle size distribution (PSD), and polymorphic form, processing parameters such as anti-solvent type, a mixture of IPA/Hex, pure Hex, or pure acetone; stirring speeds of 500, 600, 700, or 800 rpm; and temperatures ranging from 25 to 40 °C were explored. The effects of these parameters on spherical crystallization and polymorphic form were studied in terms of supersaturation, a driving force for polymorphic transformation, and the crystallization solution. Notably, our method does not require a large volume of anti-solvent which is the main complication of conventional anti-solvent crystallization methods.

scholarly journals Particle design of tolbutamide by the spherical crystallization technique. II. Factors causing polymorphism of tolbutamide spherical agglomerates.

1989 ◽  
Vol 37 (8) ◽  
pp. 2183-2187 ◽  
Author(s):  
Akimitsu SANO ◽  
Takeo KURIKI ◽  
Yoshiaki KAWASHIMA ◽  
Hirofumi TAKEUCHI ◽  
Toshiyuki NIWA
Keyword(s):  
Spherical Crystallization ◽  
Spherical Agglomerates

Single Crystal Growth of High-Pressure Phases of Ice and Salt Hydrate Far Below the Original Melting Point by Mixing Alcohol: Crystal Structure Determination of Magnesium Chloride Heptahydrate

2020 ◽  
Author(s):  
Keishiro Yamashita ◽  
Kazuki Komatsu ◽  
Hiroyuki Kagi
Keyword(s):  
Crystal Structure ◽  
High Pressure ◽  
Crystal Growth ◽  
Single Crystal ◽  
Room Temperature ◽  
Growth Technique ◽  
Salt Hydrate ◽  
X Ray

An crystal-growth technique for single crystal x-ray structure analysis of high-pressure forms of hydrogen-bonded crystals is proposed. We used alcohol mixture (methanol: ethanol = 4:1 in volumetric ratio), which is a widely used pressure transmitting medium, inhibiting the nucleation and growth of unwanted crystals. In this paper, two kinds of single crystals which have not been obtained using a conventional experimental technique were obtained using this technique: ice VI at 1.99 GPa and MgCl<sub>2</sub>·7H<sub>2</sub>O at 2.50 GPa at room temperature. Here we first report the crystal structure of MgCl2·7H2O. This technique simultaneously meets the requirement of hydrostaticity for high-pressure experiments and has feasibility for further in-situ measurements.

Aplikasi Pendayagunaan Asam In-Situ pada Kulit Pikel Terbuang untuk Pembuatan Gelatin Pangan

2016 ◽  
Vol 9 (2) ◽  
pp. 187-197
Author(s):  
Sugihartono Sugihartono
Keyword(s):  
Food Industry ◽  
Type A ◽  
Collagen Fibers ◽  
Final Phase ◽  
Acid Base ◽  
Salt Hydrate ◽  
Food Grade ◽  
Hydrolyze Collagen ◽  
Waste Acid

Skinswaste at pre-tanning operations can be processed into food grade gelatin. The degradation of collagen using acid, base, or enzymes produced gelatin. Pickle skins is skins that acidified, the results of the final phase of the pre-tanning operations. The addition of salt on the skin makes the skins pickle not swollen, produced a wide space between collagen fibers and collagen can not be degraded. Thereby directly extract pickle skins or waste will not be obtained gelatin.This study discussed the processing of food gelatin type A pickle skins through the utilization of waste acid it contains. The discussion includes the components of animal skins, pre-tanning waste, acidification of skins, processing gelatin and gelatin from skins picklewaste and usefulness for the food industry. Salt hydrate collagen fibers in the skin pickle including waste can be separated by washing, to a certain extent still acidic skins waste. The remaining acid on the skins pickle waste can be utilized to hydrolyze collagen into gelatin. The resulting gelatin is gelatin type A, that can be used for food industry.ABSTRAKKulit limbah pada operasi pra-penyamakan dapat diolah menjadi gelatin pangan. Pemecahan kolagen menggunakan asam, basa, atau enzim dihasilkan gelatin. Kulit pikel merupakan kulit yang diasamkan, hasil dari tahap akhir operasi pra-penyamakan. Penambahan garam pada kulit pikel menjadikan kulit tidak bengkak, menghasilkan ruang lebar diantara serat kolagen dan menjadikan kolagen tidak dapat terdegradasi. Hal ini berarti ekstrak secara langsung kulit pikel atau limbahnya tidak akan diperoleh gelatin. Dalam kajian ini dibahas pengolahan gelatin pangan tipe A dari kulit pikel limbah melalui pendayagunaan asam yang dikandungnya. Bahasan mencakup komponen kulit hewan, limbah pra-penyamakan, pengasaman kulit, pengolahan gelatin, dan pengolahan gelatin dari kulit pikel limbah melalui pendayagunaan asam yang dikandungnya serta kegunaannya untuk industri pangan. Garam yang menghidrasi serat kolagen pada kulit pikel termasuk limbahnya dapat dipisahkan dengan cara pencucian, sampai batas tertentu kulit limbah masih bersifat asam. Asam yang tersisa pada kulit pikel limbah tersebut dapat didayagunakan untuk menghidrolisis kolagen menjadi gelatin. Gelatin yang dihasilkan adalah gelatin tipe A, dapat digunakan untuk keperluan industri pangan. Kata kunci : Kulit pikel limbah, gelatin, pengasaman, pangan.

Flexural Resistance of Steel-Coconut Shell Concrete-Steel Composite Beam with Normal and J-Hook Shear Studs

2020 ◽  
Vol 12 (9) ◽  
Author(s):  
Lakshmi Thangasamy ◽  
◽  
Gunasekaran Kandasamy ◽  
Keyword(s):  
Concrete Strength ◽  
Steel Plates ◽  
Coconut Shell ◽  
Core Material ◽  
River Sand ◽  
Concrete Core ◽  
Conventional Concrete ◽  
Moment Capacity ◽  
The Moment ◽  
Core Concrete

Many researches on double skin sandwich having top and bottom steel plates and in between concrete core called as steel-concrete-steel (SCS) were carried out by them on this SCS type using with different materials. Yet, use of coconut shell concrete (CSC) as a core material on this SCS form construction and their results are very limited. Study investigated to use j-hook shear studs under flexure in the concept of steel-concrete-steel (SCS) in which the core concrete was CSC. To compare the results of CSC, the conventional concrete (CC) was also considered. To study the effect of quarry dust (QD) in its place of river sand (RS) was also taken. Hence four different mixes two without QD and two with QD both in CC and CSC was considered. The problem statement is to examine about partial and fully composite, moment capacity, deflection and ductility properties of CSC used SCS form of construction. Core concrete strength and the j-hook shear studs used are influences the moment carrying capacity of the SCS beams. Use of QD in its place of RS enhances the strength of concrete produced. Deflections predicted theoretically were compared with experimental results. The SCS beams showed good ductility behavior.

The Flow Behavior of Core Material and Breakthrough Phenomenon in Sandwich Injection Molding

2003 ◽  
Vol 18 (4) ◽  
pp. 405-411 ◽  
Author(s):  
D. Watanabe ◽  
U. S. Ishiaku ◽  
T. Nagaoka ◽  
K. Tomari ◽  
H. Hamada
Keyword(s):  
Injection Molding ◽  
Flow Behavior ◽  
Core Material
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